Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Xin-Xin I Zeng"'
Autor:
Jeanne L Theis, Georg Vogler, Maria A Missinato, Xing Li, Tanja Nielsen, Xin-Xin I Zeng, Almudena Martinez-Fernandez, Stanley M Walls, Anaïs Kervadec, James N Kezos, Katja Birker, Jared M Evans, Megan M O'Byrne, Zachary C Fogarty, André Terzic, Paul Grossfeld, Karen Ocorr, Timothy J Nelson, Timothy M Olson, Alexandre R Colas, Rolf Bodmer
Publikováno v:
eLife, Vol 9 (2020)
Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically complex and poorly understood. Here, a multidisciplinary platform was established to functionally evaluate novel CHD gene candidates, based on whole-g
Externí odkaz:
https://doaj.org/article/7b02a3ed48a047c4bd8549ffe623c1c1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Saul–Wilson syndrome (SWS) is a rare, skeletal dysplasia with progeroid appearance and primordial dwarfism. It is caused by a heterozygous, dominant variant (p.G516R) in COG4, a subunit of the conserved oligomeric Golgi (COG) complex involved in in
Externí odkaz:
https://doaj.org/article/3dbcf0cc5b034172a8a424e5a97cb95c
Autor:
Xinlu Zhang, Ting Feng, Xin-Xin I. Zeng, Hongbin Liang, Bo Situ, Qiuxia Zhang, Fengyun Zhou, Yejia Chen, Tao Wang, Du Cai, Xinxin Lin, Jiancheng Xiu, Lei Zheng
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Arterial remodeling is a major pathological consequence of hypertension, which is recognized as the most common chronic non-communicable disease. However, the detailed mechanism of how arterial remodeling is induced by hypertension has not yet been f
Externí odkaz:
https://doaj.org/article/79fc2ffe511d49c385c42ad945da5b51
Autor:
Danhua Zhang, Keith P. Gates, Lindsey Barske, Guangliang Wang, Joseph J. Lancman, Xin-Xin I. Zeng, Megan Groff, Kasper Wang, Michael J. Parsons, J. Gage Crump, P. Duc Si Dong
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The hepatopancreatic duct cells connect liver hepatocytes and pancreatic acinar cells to the intestine, but the mechanism for their lineage specification is unclear. Here, the authors reveal that Notch ligands Jagged1b and Jagged2b induce duct cell l
Externí odkaz:
https://doaj.org/article/9a869d75f80549c8a2ff75e1bc7269a8
Autor:
Tanja Nielsen, Anaïs Kervadec, Maria A. Missinato, Michaela Lynott, Xin-Xin I. Zeng, Marie Berenguer, Stanley M. Walls, Analyne Schroeder, Katja Birker, Greg Duester, Paul Grossfeld, Timothy J. Nelson, Timothy M. Olson, Karen Ocorr, Rolf Bodmer, Jeanne L. Theis, Georg Vogler, Alexandre R. Colas
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD). The pathogenesis of HLHS is poorly understood and due to the likely oligogenic complexity of the disease, definitive HLHS-causing genes have not yet been identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d332e5aa3bd31779e9bf74cf83b82f
https://doi.org/10.1101/2022.07.01.22277112
https://doi.org/10.1101/2022.07.01.22277112
Autor:
Xin-Xin I. Zeng, Deborah Yelon
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 951-960 (2014)
Heart assembly requires input from two populations of progenitor cells, the first and second heart fields (FHF and SHF), that differentiate at distinct times and create different cardiac components. The cardiac outflow tract (OFT) is built through re
Externí odkaz:
https://doaj.org/article/8dffdfeb933b4360b8d4d54a292c7d1f
Saul-Wilson syndrome (SWS) is a rare, skeletal dysplasia with progeroid appearance and primordial dwarfism. It is caused by a heterozygous, dominant variant (p.G516R) in COG4, a subunit of the Conserved Oligomeric Golgi (COG) complex involved in intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b77dfe017018ff6f6fb97a108651af
https://doi.org/10.1101/2021.05.23.443307
https://doi.org/10.1101/2021.05.23.443307
Autor:
David Traver, Raquel Espin Palazon, Clyde Campbell, Joseph J. Lancman, P. Duc Si Dong, Xin-Xin I. Zeng, Jonatan Matalonga, Jan Huisken, Alyssa Graves, Jiaye He, Rashmi Mishra
The extent to which differentiated cells, while remaining in their native microenvironment, can be reprogrammed to assume a different identity will reveal fundamental insight into cellular plasticity and impact regenerative medicine. To investigatein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14822b942dd987f4d679f623f28318e6
Autor:
Xuanyi Ma, Shaochen Chen, Elie Farah, Weizhe Xu, Hannah G. Knight, Rima Deshpande, Joshua Bloomekatz, Ruilin Zhang, Neil C. Chi, Deborah Yelon, Peidong Han, Alec D. Witty, Xin-Xin I. Zeng, Jie Ren, Megan M. Swim
Publikováno v:
Developmental cell. 50(6)
Pacemaker cardiomyocytes that create the sinoatrial node are essential for the initiation and maintenance of proper heart rhythm. However, illuminating developmental cues that direct their differentiation has remained particularly challenging due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51de43a41bfb3899afc56d1021a77dbd
https://pubmed.ncbi.nlm.nih.gov/31550460
https://pubmed.ncbi.nlm.nih.gov/31550460
Autor:
Lindsey Barske, P. Duc Si Dong, Guangliang Wang, Xin-Xin I. Zeng, Michael J. Parsons, Megan Groff, Danhua Zhang, Kasper S. Wang, Joseph J. Lancman, J. Gage Crump, Keith P. Gates
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Liver duct paucity is characteristic of children born with Alagille Syndrome (ALGS), a disease associated with JAGGED1 mutations. Here, we report that zebrafish embryos with compound homozygous mutations in two Notch ligand genes, jagged1b (jag1b) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1071e3e0edc7f0d982d034fe67797ed
https://doi.org/10.1038/s41467-017-00666-6
https://doi.org/10.1038/s41467-017-00666-6