Simvastatin reduces the TLR4-induced inflammatory response in human aortic valve interstitial cells

Autor: Quinzhou Yao, Xin-Sheng Deng, Neil Venardos, T. Brett Reece, David A. Fullerton, Xianzhong Meng, Michael J. Weyant

Publikováno v: Journal of Surgical Research. 230:101-109

Background Calcific aortic stenosis is a chronic inflammatory disease. Proinflammatory stimulation via toll-like receptor 4 (TLR4) causes the aortic valve interstitial cell (AVIC) to undergo phenotypic change. The AVIC first assumes an inflammatory p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7249e7d53034af79d07d78d43c4c8e
https://doi.org/10.1016/j.jss.2018.04.054

MMP-12–Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells

Autor: Fei Li, James Jaggers, Xianzhong Meng, Xin-Sheng Deng, David A. Fullerton, Neil Venardos

Background Calcific aortic valve disease (CAVD) is an age-related and slowly progressive valvular disorder. Overexpression of matrix metalloproteinase 12 (MMP-12) has been found in atherosclerosis, stiffed vascular tissue, and calcified aortic valves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5701ca3a11c0bea39daf0da51e01ce67
https://europepmc.org/articles/PMC6791591/

Glucose promotes breast cancer aggression and reduces metformin efficacy

Autor: Xin-Sheng Deng, Jennifer K. Richer, Susan M. Edgerton, Zeying Fan, Sigrid Salling Arnadottir, Ann D. Thor, Reema Wahdan-Alaswad, Bolin Liu, Steven M. Anderson

Publikováno v: Cell Cycle
Wahdan-Alaswad, R, Fan, Z, Edgerton, S M, Liu, B, Deng, X-S, Árnadóttir, S S, Richer, J K, Anderson, S M & Thor, A D 2013, ' Glucose promotes breast cancer aggression and reduces metformin efficacy ', Cell Cycle, vol. 12, no. 24 .

Metformin treatment has been associated with a decrease in breast cancer risk and improved survival. Metformin induces complex cellular changes, resulting in decreased tumor cell proliferation, reduction of stem cells, and apoptosis. Using a carcinog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f112c11306c41c8af23683551054686
https://doi.org/10.4161/cc.26641

Autophagy negatively regulates pro-osteogenic activity in human aortic valve interstitial cells

Autor: Rui Song, Katsuhiro Yamanaka, Xianzhong Meng, Xin-Sheng Deng, James Jaggers, David A. Fullerton, Neil Venardos

Publikováno v: The Journal of surgical research. 218

Background Autophagy is a physiological process that plays an important role in maintaining cellular functions. When aortic valve interstitial cells (AVICs) are stimulated with inflammatory or mechanical stress, one response is elevated pro-osteogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bf23cdf66518766f4ec6326d95e997
https://pubmed.ncbi.nlm.nih.gov/28985862

Abstract PD03-09: Metformin Induces Apoptosis in Triple Negative Breast Cancer Cells Via Inhibition of Stat3 Activity

Autor: Xin-Sheng Deng, Ad. Thor, A Deng, Susan M. Edgerton, Bolin Liu, S Wang

Publikováno v: Cancer Research. 70:PD03-09

Background: Metformin inhibits breast cancer cell proliferation and colony formation, with S phase arrest and the induction of apoptosis in triple negative breast cancer cells in vitro. In these cells, metformin down-regulates Cyclin D1 and Cyclin E,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f38005e0f45f0245670d0d7ed8cc0aa8
https://doi.org/10.1158/0008-5472.sabcs10-pd03-09