Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Xin-Qiu Yao"'
Autor:
Xin-Qiu Yao, Donald Hamelberg
Publikováno v:
JACS Au, Vol 4, Iss 2, Pp 837-846 (2024)
Externí odkaz:
https://doaj.org/article/9848dff11f98491bb757f1bb0038530d
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 11, p e1006364 (2018)
GTPases regulate a multitude of essential cellular processes ranging from movement and division to differentiation and neuronal activity. These ubiquitous enzymes operate by hydrolyzing GTP to GDP with associated conformational changes that modulate
Externí odkaz:
https://doaj.org/article/199e85a542114130bf762a1f2a90793a
Publikováno v:
The Journal of Physical Chemistry B. 127:3139-3150
Publikováno v:
Biochemistry. 62:1070-1081
Publikováno v:
The Journal of Physical Chemistry B. 126:10844-10853
Mitochondria are the powerhouse of a cell, whose disruption due to mitochondrial pore opening can cause cell death, leading to necrosis and many other diseases. The peptidyl-prolyl
Residue–Residue Contact Changes during Functional Processes Define Allosteric Communication Pathways
Autor:
Xin-Qiu Yao, Donald Hamelberg
Publikováno v:
Journal of Chemical Theory and Computation. 18:1173-1187
Allosteric regulation plays a central role in orchestrating diverse cellular processes. A prerequisite for allostery is a flexible biomolecule within which two distal sites can communicate via concerted or sequential conformational changes. We introd
Autor:
Xin-Qiu Yao, Ning Fang, Angela M. Mabb, Zheng Zachory Wei, Daniel Ouedraogo, Giovanni Gadda, You Zhuo, Ken Berglund, Bin Dong, Cheyenne McBean, Xiaonan Deng, Shan Ping Yu, Jenny J. Yang, Samer Gozem, Mohammad A Ghane, Ling Wei, Donald Hamelberg
Publikováno v:
Angewandte Chemie. 133:23477-23486
Multi-scale calcium (Ca2+ ) dynamics, exhibiting wide-ranging temporal kinetics, constitutes a ubiquitous mode of signal transduction. We report a novel endoplasmic-reticulum (ER)-targeted Ca2+ indicator, R-CatchER, which showed superior kinetics in
Autor:
Zhuang Li, Anthony A. Kossiakoff, Qiuyan Chen, Xin-Qiu Yao, Leifu Chang, Thomas Klose, Somnath Mukherjee, Chun-Liang Chen, Manolo Plasencia, Dhabaleswar Patra, Philip C. Andrews, John J.G. Tesmer
Publikováno v:
Nature
G-protein-coupled receptor (GPCR) kinases (GRKs) selectively phosphorylate activated GPCRs, thereby priming them for desensitization1. Although it is unclear how GRKs recognize these receptors2-4, a conserved region at the GRK N terminus is essential
Autor:
Xin-Qiu Yao, Donald Hamelberg
Publikováno v:
The journal of physical chemistry. B. 126(14)
Initiation of biological processes involving protein-ligand binding, transient protein-protein interactions, or amino acid modifications alters the conformational dynamics of proteins. Accompanying these biological processes are ensuing coupled atomi
Publikováno v:
ACS Catalysis. 10:1810-1820
Allosteric regulations of the catalytic activity of enzymes in cellular processes remain poorly understood. Here, we advance the understanding of these critical processes by providing insights into...