Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Xin-Ke Yin"'
Autor:
Jie Shi, Si-Ying Chen, Xiao-Ting Shen, Xin-Ke Yin, Wan-Wen Zhao, Shao-Mei Bai, Wei-Xing Feng, Li-Li Feng, Caolitao Qin, Jian Zheng, Yun-Long Wang, Xin-Juan Fan
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Aberrant DNA damage response (DDR) axis remains the major molecular mechanism for tumor radio-resistance. We recently characterized liquid-liquid phase separation (LLPS) as an essential mechanism of DDR, and identified several key DDR factor
Externí odkaz:
https://doaj.org/article/1e022d1f00074070bf2839334ea96bbf
Autor:
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Yan Ma, Xin-Ke Yin, Li-Li Feng, Guang-Dong Zeng, Fang Wang, Wei-Xing Feng, Jian Zheng, Ying-Nai Wang, Bing Zeng, Quentin Liu, Mien-Chie Hung, Xiang-Bo Wan
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-13 (2022)
Abstract Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand breaks (DSB) repair, whereas its
Externí odkaz:
https://doaj.org/article/67b2f196f89c4d2e98e308070287c485
Autor:
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng, Shu-Ying Bie, Li Gong, Fang Wang, Ming-Biao Wei, Wei-Xing Feng, Xiao-Lin Pang, Cao-Litao Qin, Xin-Ke Yin, Ying-Nai Wang, Weihua Zhou, Daniel R. Wahl, Quentin Liu, Ming Chen, Mien-Chie Hung, Xiang-Bo Wan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The MRN complex is a critical sensor and processor of DNA double-strand breaks (DSBs). Here, the authors show that MRNIP forms liquid-like condensates to accelerate the MRN-mediated sensing and end resection of DSB, thereby promoting DSB repair.
Externí odkaz:
https://doaj.org/article/0d2d630dc0a747b8807be46604e76da1
Autor:
Xin-Ke Yin, Chao Wang, Li-Li Feng, Shao-Mei Bai, Wei-Xing Feng, Neng-Tai Ouyang, Zhong-Hua Chu, Xin-Juan Fan, Qi-Yuan Qin
Publikováno v:
Cancers; Volume 14; Issue 22; Pages: 5573
The synergistic effect of combining immune checkpoint inhibitors (ICIs) with neoadjuvant chemo(radio)therapy (nCRT) in colorectal cancer is still limited. We aimed to understand the impact of nCRT on the tumor microenvironment and to explore favorabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48154b84aa9134089e78c3cca1cfb16d
Autor:
Xiang Bo Wan, Yan Huang, Cao Litao Qin, Wan Wen Zhao, Quentin Liu, Fei Wang, Pei Yi Xie, Zhi Li Chen, Ying Nai Wang, Xin Ke Yin, Jun Wei Hou, Y. Wang, Ming Biao Wei, Li-Li Feng, Shao Mei Bai, Fang Wang, Xin Juan Fan, Hong Jun Yi, Wei Xing Feng, Mien Chie Hung, Chia Wei Li, Taewan Kim
Publikováno v:
Oncogene
Arginine methylation is an important posttranslational modification catalyzed by protein arginine methyltransferases (PRMTs). However, the role of PRMTs in colorectal cancer (CRC) progression is not well understood. Here we report that non-POU domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be130a9de8d6fed76d135093fe2877c3
http://europepmc.org/articles/PMC7892343
http://europepmc.org/articles/PMC7892343
Autor:
Yi-Kan Cheng, Xin-Ke Yin, Shao-Mei Bai, Wang Yunlong, Xiang-Bo Wan, Xinjuan Fan, Haiyang Chen, Jian Zheng, Fang He, Xiaolin Pang, Dalu Zhang, Shuai Liu, Ming-Biao Wei, Lei Wang, Wan-Wen Zhao, Wei-Xing Feng, Junxiang Yin, Li-Li Feng
Publikováno v:
Journal of Bio-X Research, Vol 2, Iss 1, Pp 1-8 (2019)
Programmed death ligand-1 (PD-L1) is involved in inhibiting of T lymphocyte proliferation, producing cytokine, cytolytic activity, and suppressing of the immune response. Genes with molecular alterations involved in DNA mismatch repair promote cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e93cd0b909f6d941ce03d775776b44
http://journals.lww.com/10.1097/JBR.0000000000000025
http://journals.lww.com/10.1097/JBR.0000000000000025
Autor:
Jun Xiang Yin, Lei Wang, Y. Wang, Wei Xing Feng, Yan Huang, Xin Hui Fu, Hong Jun Yi, Pei Huang Wu, Xiang Bo Wan, Shao Mei Bai, Xin Juan Fan, Xi Hu Yu, Zhi Ting Chen, Xin Ke Yin, Gordon B. Mills, Li-Li Feng, Da Lu Zhang, Taewan Kim, Yi Ling Lu
Publikováno v:
Journal of Cancer
Tissue-derived RNA, DNA and protein samples become more and more crucial for molecular detection in clinical research, personalized and targeted cancer therapy. This study evaluated how to biobanking colorectal tissues through examining the influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623aff9425708d1172945b2cf8772a41
https://doi.org/10.7150/jca.29372
https://doi.org/10.7150/jca.29372
Autor:
Yun-Long Wang, Wan-Wen Zhao, Shao-Mei Bai, Li-Li Feng, Shu-Ying Bie, Li Gong, Fang Wang, Ming-Biao Wei, Wei-Xing Feng, Xiao-Lin Pang, Cao-Litao Qin, Xin-Ke Yin, Ying-Nai Wang, Weihua Zhou, Daniel R. Wahl, Quentin Liu, Ming Chen, Mien-Chie Hung, Xiang-Bo Wan
Publikováno v:
Nature communications. 13(1)
The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA damage response and DSB end resection. Here, we show that MRN complex interacting protein (MRNIP) forms liquid-like c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70457948559196bed4ddf8a076c8e3a5
https://pubmed.ncbi.nlm.nih.gov/35551189
https://pubmed.ncbi.nlm.nih.gov/35551189
Autor:
Xin-Juan, Fan, Yun-Long, Wang, Wan-Wen, Zhao, Shao-Mei, Bai, Yan, Ma, Xin-Ke, Yin, Li-Li, Feng, Wei-Xing, Feng, Ying-Nai, Wang, Quentin, Liu, Mien-Chie, Hung, Xiang-Bo, Wan
Publikováno v:
Am J Cancer Res
Radioresistance is one of the main causes of cancer treatment failure, which leads to relapse and inferior survival outcome of cancer patients. Liquid-liquid phase separation (LLPS) of proteins is known to be involved in various biological processes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0929544a44b28f6c179fd3d6fff43e6d
https://pubmed.ncbi.nlm.nih.gov/34249431
https://pubmed.ncbi.nlm.nih.gov/34249431
Publikováno v:
2009 ETP International Conference on Future Computer and Communication.
In this paper, we analyze the driving force of technological innovation based on Principal Component Analysis (PCA) and Factor Analysis (FA) using scientific and technological data from 8 relatively developed provinces (municipalities) in Eastern Chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cba7630d0f3dfff8c37ca3a4578d50a
https://doi.org/10.1109/fcc.2009.39
https://doi.org/10.1109/fcc.2009.39