Zobrazeno 1 - 10
of 205
pro vyhledávání: '"Xin Yun Huang"'
Autor:
CheukMan C Au, John B Furness, Kara Britt, Sofya Oshchepkova, Heta Ladumor, Kai Ying Soo, Brid Callaghan, Celine Gerard, Giorgio Inghirami, Vivek Mittal, Yufeng Wang, Xin Yun Huang, Jason A Spector, Eleni Andreopoulou, Paul Zumbo, Doron Betel, Lukas Dow, Kristy A Brown
Publikováno v:
eLife, Vol 9 (2020)
Breast cancer is the most common type of cancer in women and notwithstanding important therapeutic advances, remains the second leading cause of cancer-related death. Despite extensive research relating to the hormone ghrelin, responsible for the sti
Externí odkaz:
https://doaj.org/article/d89e185dd92b446193eb7a5df65c3161
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 9, Pp 1952-1966 (2024)
Abstract Agonists targeting α2-adrenergic receptors (ARs) are used to treat diverse conditions, including hypertension, attention-deficit/hyperactivity disorder, pain, panic disorders, opioid and alcohol withdrawal symptoms, and cigarette cravings.
Externí odkaz:
https://doaj.org/article/39057a4010c94a3f87205a27fe7825f5
Autor:
Jie Xiong, Shu Cheng, Xiao Gao, Shan-He Yu, Yu-Ting Dai, Xin-Yun Huang, Hui-Juan Zhong, Chao-Fu Wang, Hong-Mei Yi, Hao Zhang, Wei-Guo Cao, Rong Li, Wei Tang, Yan Zhao, Peng-Peng Xu, Li Wang, Wei-Li Zhao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive chemotherapy. To explore effective and safe treatment for newly diagnosed advanced stage NKTCL, we conducted a phase II
Externí odkaz:
https://doaj.org/article/86ceca8eb03c4db8b1b374d52b9cbacd
Autor:
Minfei Su, Jinan Wang, Guoqing Xiang, Hung Nguyen Do, Joshua Levitz, Yinglong Miao, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract α1-adrenergic receptors (α1-ARs) play critical roles in the cardiovascular and nervous systems where they regulate blood pressure, cognition, and metabolism. However, the lack of specific agonists for all α1 subtypes has limited our under
Externí odkaz:
https://doaj.org/article/63dfe8288c9a4a048a21d6655a5086b0
Autor:
Yue Zhao, Guang Yang, Yun-Qiong Lu, Mei-Yan Li, Jue Hong, Yan-Ting Yang, Xue-Jun Wang, Xie-He Kong, Zhao Ma, Xin-Yun Huang, Yue-Lan Zou, Xing-Tao Zhou, Xiao-Peng Ma
Publikováno v:
BMJ Open, Vol 13, Iss 12 (2023)
Introduction Dry eye (DE) is a multifactorial ocular surface disease causing considerable medical, social and financial implications. Currently, there is no recognised long-term, effective treatment to alleviate DE. Clinical evidence shows that elect
Externí odkaz:
https://doaj.org/article/afb9874637274ef2a1edb4e4ace6b256
Autor:
Shian Liu, Navid Paknejad, Lan Zhu, Yasuyuki Kihara, Manisha Ray, Jerold Chun, Wei Liu, Richard K. Hite, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Liu et al. report structures of human sphingosine 1-phosphate (S1P) receptor 1 (S1P1) in complex with Gi and S1P or the multiple sclerosis (MS) drug Siponimod, as well as human lysophosphatidic acid (LPA) receptor 1 (LPA1) in complex with Gi and LPA,
Externí odkaz:
https://doaj.org/article/58134eb70a4a45f6ab8809cc247dec49
Autor:
Yufeng Wang, Mei Song, Ming Liu, Guoan Zhang, Xian Zhang, Ming O. Li, Xiaojing Ma, J. Jillian Zhang, Xin-Yun Huang
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108948- (2021)
Summary: Fascin protein is the main actin-bundling protein in filopodia and invadopodia, which are critical for tumor cell migration, invasion, and metastasis. Small-molecule fascin inhibitors block tumor invasion and metastasis and increase the over
Externí odkaz:
https://doaj.org/article/3739b8d3456f49e187329e924e506e05
Autor:
Nancy Nader, Maya Dib, Rawad Hodeify, Raphael Courjaret, Asha Elmi, Ayat S Hammad, Raja Dey, Xin-Yun Huang, Khaled Machaca
Publikováno v:
PLoS Biology, Vol 19, Iss 2, p e3001117 (2021)
[This corrects the article DOI: 10.1371/journal.pbio.3000901.].
Externí odkaz:
https://doaj.org/article/10137d2cafb141fba378d7cb7900871e
Autor:
Nancy Nader, Maya Dib, Rawad Hodeify, Raphael Courjaret, Asha Elmi, Ayat S Hammad, Raja Dey, Xin-Yun Huang, Khaled Machaca
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000901 (2020)
The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4 receptors (mPRs) that mediate nongenomic signaling. mPR signaling remains poorly understood. Her
Externí odkaz:
https://doaj.org/article/da39de1e2d754001a84874e8d7594309
Autor:
Shaoqin Han, Jianyun Huang, Bingqian Liu, Bowen Xing, Francois Bordeleau, Cynthia A. Reinhart-King, Wenxin Li, J. Jillian Zhang, Xin-Yun Huang
Publikováno v:
Molecular Oncology, Vol 10, Iss 7, Pp 966-980 (2016)
Tumor metastasis is the major cause of mortality of cancer patients, being responsible for ∼90% of all cancer deaths. One of the key steps during tumor metastasis is tumor cell migration which requires actin cytoskeletal reorganization. Among the c
Externí odkaz:
https://doaj.org/article/3c6aa1559fc64dbe851d5e4d20f47ae8