Abstract 1267: Dual approach using unbiased proteomics and multiplexed immunofluorescence for the detection of markers predictive for immunotherapy in melanoma patients

Autor: Anna Juncker-Jensen, Nigel Beaton, Kristina Beeler, Tobias Treiber, Mitchell Levesque, Julia M. Gomez, Harry Nunns, Xin-Xing Tan, Jakob Vowinckel

Publikováno v: Cancer Research. 82:1267-1267

Background: Remarkable clinical success with immune checkpoint inhibitor (ICI) therapy has been achieved in recent years for the treatment of melanoma. However, despite the clinical advances of ICI therapy no durable responses are observed in 40-60%

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c98a5c4d7ad11660a37437176b0d0e3b
https://doi.org/10.1158/1538-7445.am2022-1267

Abstract 2778: Validation of a next generation sequencing clinical assay for detection of immunoglobulin heavy chain clonality and somatic hypermutation in chronic lymphocytic leukemia

Autor: Xin-Xing Tan, Tricia Peters, Meredith Berry, Kristyn Jeter, Brigitte Lovell, Victor Venegas, Yanglong Mou, Brad Thomas, Vincent Funari, Josette William

Publikováno v: Cancer Research. 82:2778-2778

Next-generation sequencing (NGS) provides a powerful high-throughput approach to identify and track B-cell immunoglobulin (IG) heavy chain clonality and to assess somatic hypermutation status in a massively parallel manner. The NGS-based clonality/SH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::006ca67141c913a28a9afab0e2d36051
https://doi.org/10.1158/1538-7445.am2022-2778

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

Autor: Jan Hellemans, Hans Binder, Jean Thierry-Mieg, Joshua Xu, Djork-Arné Clevert, Peter Sykacek, Matthias Fischer, Youping Deng, Samir Lababidi, Ryan Peters, Hanlin Gao, Craig A. Praul, Meihua Gong, Jo Vandesompele, Haiqing Li, Wei Wang, Joaquín Dopazo, Shawn Levy, Yang Liao, John Zhang, Lee Thomas Szkotnicki, Paul Zumbo, Huixiao Hong, Weida Tong, Quan Zhen Li, E. Aubrey Thompson, Jennifer G. Catalano, Danielle Thierry-Mieg, Binsheng Gong, Wenwei Zhang, Wendell D. Jones, Min Jian, Dalila B. Megherbi, Lucille Rainbow, Robert Setterquist, Peng Li, Hong Fang, Javier Pérez-Florido, Xin Lu, Chen Zhao, Stephen J. Walker, Tao Qing, Marco Chierici, Yiming Zhou, Joseph Meehan, Christopher E. Mason, Eric D. Wieben, Mehdi Pirooznia, Liqing Wan, Bimeng Tu, Stan Letovsky, James C. Fuscoe, Sepp Hochreiter, Yoichi Gondo, Alicia Vela-Boza, Bridgett Green, Li Li, Zirui Dong, Weimin Cai, Geng Chen, Pedro Furió-Tarí, Andreas Scherer, Zhenqiang Su, Scott Schwartz, Charles Wang, Frank Staedtler, Jian Wang, Wenzhong Xiao, Yong Yang, Murray H. Brilliant, Wei Shi, Scott S. Auerbach, Matthew Tinning, Yongxiang Fang, Tingting Du, Meiwen Jia, Jiekun Xuan, Shiyong Li, Yan Li, Ying Yu, Adnan Derti, Ruchir R. Shah, Nadereh Jafari, Nancy Stralis-Pavese, Edward J. Oakeley, Jinhui Wang, Pierre R. Bushel, Jun Wang, Simon Lin, Joost H.M. van Delft, Francisco Javier López, Weigong Ge, Huan Gao, James C. Willey, Roger Perkins, Xin Xing Tan, Viswanath Devanarayan, Laure Sambourg, Zhiyu Peng, Po Yen Wu, Jianying Li, Philippe Rocca-Serra, Javier Santoyo-Lopez, Paweł P. Łabaj, David P. Kreil, Elia Stupka, John H. Phan, Heng Luo, Gary P. Schroth, Roderick V. Jensen, Thomas M. Blomquist, Russell D. Wolfinger, John F. Thompson, Wenqian Zhang, Nan Mei, Suzanne Kay, May D. Wang, Tzu Ming Chu, Jie Shen, Jiri Zavadil, Weihong Xu, Wenjun Bao, Akhilesh Pandey, Rong Chen, Leming Shi, Yutaka Suzuki, Todd M. Smith, Chao Guo, Zhuolin Gong, Feng Qian, Mario Fasold, Lei Guo, Ching-Wei Chang, Reagan Kelly, Ana Conesa, Yate Ching Yuan, Cesare Furlanello, Elisa Venturini, Zhan Ye, Yuanting Zheng, Jos C. S. Kleinjans, James Hadfield, Susanna-Assunta Sansone, Gordon K. Smyth, Li Wu Guo, Stan Gaj, Oliver Stegle, Yanyan Zhang, Tao Chen, Ye Yin, Anita Fernandez, Tieliu Shi, Charles D. Johnson, Baitang Ning, Fei Lu, Florian Caimet, Bing Mu, Jorge Gandara, Ke Zhang, Sheng Li, Xiwen Ma

Publikováno v: Nature biotechnology
Nature Biotechnology, 32(9), 903-914. Nature Publishing Group

We present primary results from the Sequencing Quality Control (SEQC) project, coordinated by the US Food and Drug Administration. Examining Illumina HiSeq, Life Technologies SOLiD and Roche 454 platforms at multiple laboratory sites using reference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f574fbd57cb9cc567146ad9815046e12
https://doi.org/10.1038/nbt.2957

Hox Transcription Factor Ultrabithorax Ib Physically and Genetically Interacts with Disconnected Interacting Protein 1, a Double-stranded RNA-binding Protein

Autor: Likun Li, Daniel J. Catanese, Sarah E. Bondos, Kathleen S. Matthews, Alicia Bicknell, Xin Xing Tan

Publikováno v: Journal of Biological Chemistry. 279:26433-26444

The Hox protein family consists of homeodomain-containing transcription factors that are primary determinants of cell fate during animal development. Specific Hox function appears to rely on protein-protein interactions; however, the partners involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d13ce02f69f7766da57facdcc09243d
https://doi.org/10.1074/jbc.m312842200

Physical and genetic interactions link hox function with diverse transcription factors and cell signaling proteins

Autor: Sarah E. Bondos, Xin-Xing Tan, Kathleen S. Matthews

Publikováno v: Molecularcellular proteomics : MCP. 5(5)

Positional information provided by Hox homeotic transcription factors is integrated with other transcription factors and cell signaling cascades in specific combinations to dictate context- and gene-specific Hox activity. Protein-protein interactions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43e006146cf2e2649458d7bc03b46e0
https://pubmed.ncbi.nlm.nih.gov/16455680