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Akademický článek

A Novel Predictor of Pathologic Complete Response for Neoadjuvant Immunochemotherapy in Resectable Locally Advanced Esophageal Squamous Cell Carcinoma

Autor: Yang Y, Xin D, Wang H, Guan L, Meng X, Lu T, Bai X, Wang F

Publikováno v: Journal of Inflammation Research, Vol Volume 16, Pp 1443-1455 (2023)

Yalan Yang,1,* Dao Xin,2,* Huike Wang,1,* Lulu Guan,1 Xiangrui Meng,1 Taiying Lu,1 Xiwen Bai,3 Feng Wang1 1Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department

Externí odkaz: https://doaj.org/article/b823fab943e44d74ace6c99670439e72

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Akademický článek

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

Autor: Elliot H. Choi, Susie Suh, Andrzej T. Foik, Henri Leinonen, Gregory A. Newby, Xin D. Gao, Samagya Banskota, Thanh Hoang, Samuel W. Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C. Lyon, David R. Liu, Krzysztof Palczewski

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Leber congenital amaurosis is caused by mutations in RPE65 and leads to retinal degeneration in children. Here, the authors show that in vivo base editing can prolong the survival of cone photoreceptors and rescue their function in a mouse model of t

Externí odkaz: https://doaj.org/article/ffc071797e4f4fa694375352a34ae7c4

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Akademický článek

Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway

Autor: Ke H, Liu D, Li T, Chu X, Xin D, Han M, Wang S, Wang Z

Publikováno v: Drug Design, Development and Therapy, Vol Volume 14, Pp 3827-3839 (2020)

Hongfei Ke1 ,* Dexiang Liu2 ,* Tingting Li,1 Xili Chu,1 Danqing Xin,1 Min Han,1 Shuanglian Wang,1 Zhen Wang1 1Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People

Externí odkaz: https://doaj.org/article/56e6f8742af649e1b699ecba88237ea3

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Akademický článek

Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation

Autor: Han M, Cao Y, Xue H, Chu X, Li T, Xin D, Yuan L, Ke H, Li G, Wang Z

Publikováno v: Drug Design, Development and Therapy, Vol Volume 14, Pp 2865-2876 (2020)

Min Han,1– 3 Ying Cao,2 Hao Xue,1 Xili Chu,2 Tingting Li,2 Danqing Xin,2 Lin Yuan,2 Hongfei Ke,2 Gang Li,1 Zhen Wang2 1Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, People’s R

Externí odkaz: https://doaj.org/article/b2ceb1884dcb4a31a319800341d6252d

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Akademický článek

Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury

Autor: Zhao C, Zhou X, Qiu J, Xin D, Li T, Chu X, Yuan H, Wang H, Wang Z, Wang D

Publikováno v: Drug Design, Development and Therapy, Vol Volume 13, Pp 3693-3704 (2019)

Chuanliang Zhao,1–3 Xin Zhou,1,2 Jie Qiu,1,2 Danqing Xin,2 Tingting Li,2 Xili Chu,2 Hongtao Yuan,2 Haifeng Wang,1 Zhen Wang,2 Dachuan Wang1 1Department of Spinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shando

Externí odkaz: https://doaj.org/article/f7ad230033ac4de598a574f86a432f52

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Akademický článek

NmeCas9 is an intrinsically high-fidelity genome-editing platform

Autor: Nadia Amrani, Xin D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E. Sasaki, Tong Wu, Paul D. Donohoue, Alexander H. Settle, Alexandra M. Lied, Kyle McGovern, Chris K. Fuller, Peter Cameron, Thomas G. Fazzio, Lihua Julie Zhu, Scot A. Wolfe, Erik J. Sontheimer

Publikováno v: Genome Biology, Vol 19, Iss 1, Pp 1-25 (2018)

Abstract Background The development of CRISPR genome editing has transformed biomedical research. Most applications reported thus far rely upon the Cas9 protein from Streptococcus pyogenes SF370 (SpyCas9). With many RNA guides, wildtype SpyCas9 can i

Externí odkaz: https://doaj.org/article/d001df012bc241759e81c0e2bc14037f

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Akademický článek

Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins

Autor: Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E. Lou, Ildar Gainetdinov, April Pawluk, Raed Ibraheim, Xin D. Gao, Pengpeng Liu, Alan R. Davidson, Karen L. Maxwell, Erik J. Sontheimer

Publikováno v: mBio, Vol 9, Iss 6 (2018)

ABSTRACT In their natural settings, CRISPR-Cas systems play crucial roles in bacterial and archaeal adaptive immunity to protect against phages and other mobile genetic elements, and they are also widely used as genome engineering technologies. Previ

Externí odkaz: https://doaj.org/article/235e55b82aeb4666b874a7f3a5f87dce

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