Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ximena Ibarra-Soria"'
Autor:
Celia Alda-Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Bin Sun, William Pembroke, Sebastian Ullrich, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Background Drug targets with genetic evidence are expected to increase clinical success by at least twofold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of drug discovery. A
Externí odkaz:
https://doaj.org/article/c304ef90e9444591bb08261355ae7dd1
Autor:
If H. A. Barnes, Ximena Ibarra-Soria, Stephen Fitzgerald, Jose M. Gonzalez, Claire Davidson, Matthew P. Hardy, Deepa Manthravadi, Laura Van Gerven, Mark Jorissen, Zhen Zeng, Mona Khan, Peter Mombaerts, Jennifer Harrow, Darren W. Logan, Adam Frankish
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Olfactory receptor (OR) genes are the largest multi-gene family in the mammalian genome, with 874 in human and 1483 loci in mouse (including pseudogenes). The expansion of the OR gene repertoire has occurred through numerous dupli
Externí odkaz:
https://doaj.org/article/3233a58fa54941809c8aafda7df194f7
Autor:
Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the
Externí odkaz:
https://doaj.org/article/291fa0f00ad04f14bfde9e67e60009ab
Autor:
Zhengzheng S Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E Vancollie, Ximena Ibarra-Soria, Helen V Firth, Debra Rimmington, I Sadaf Farooqi, Christopher J Lelliott, Steven C Munger, Stephen O'Rahilly, Anne C Ferguson-Smith, Anthony P Coll, Darren W Logan
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1008916 (2020)
Some imprinted genes exhibit parental origin specific expression bias rather than being transcribed exclusively from one copy. The physiological relevance of this remains poorly understood. In an analysis of brain-specific allele-biased expression, w
Externí odkaz:
https://doaj.org/article/d7e4936735004c35b3e6c52483f730c4
Autor:
Sarah J. Aitken, Ximena Ibarra-Soria, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C. Marioni, Duncan T. Odom
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background CTCF binding to DNA helps partition the mammalian genome into discrete structural and regulatory domains. Complete removal of CTCF from mammalian cells causes catastrophic genome dysregulation, likely due to widespread collapse of
Externí odkaz:
https://doaj.org/article/9c93686d4d4a439a9cb8d544dac7a88d
Autor:
Ximena Ibarra-Soria, Thiago S Nakahara, Jingtao Lilue, Yue Jiang, Casey Trimmer, Mateus AA Souza, Paulo HM Netto, Kentaro Ikegami, Nicolle R Murphy, Mairi Kusma, Andrea Kirton, Luis R Saraiva, Thomas M Keane, Hiroaki Matsunami, Joel Mainland, Fabio Papes, Darren W Logan
Publikováno v:
eLife, Vol 6 (2017)
The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes. Here, we employ
Externí odkaz:
https://doaj.org/article/15a96e0e6af7466bb3e8a8110bb7da7a
Autor:
Marco Ranzani, Vivek Iyer, Ximena Ibarra-Soria, Martin Del Castillo Velasco-Herrera, Mathew Garnett, Darren Logan, David J. Adams
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
BACKGROUND: Olfactory receptors (ORs) recognize odorant molecules and activate a signal transduction pathway that ultimately leads to the perception of smell. This process also modulates the apoptotic cycle of olfactory sensory neurons in an olfactor
Externí odkaz:
https://doaj.org/article/bf33a1f1437342d4a25fed36f444c7b2
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004593 (2014)
The olfactory (OR) and vomeronasal receptor (VR) repertoires are collectively encoded by 1700 genes and pseudogenes in the mouse genome. Most OR and VR genes were identified by comparative genomic techniques and therefore, in many of those cases, onl
Externí odkaz:
https://doaj.org/article/6ce037f9fb024157bab6ed6065d5d0b3
Autor:
Celia Alda Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Drug targets with human genetic evidence are expected to increase clinical success by at least two-fold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of early drug discovery. A key iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c18edd229f5eeebe62906e7c14bea9b
https://doi.org/10.1101/2023.05.14.540711
https://doi.org/10.1101/2023.05.14.540711
Autor:
Richard C.V. Tyser, Ximena Ibarra-Soria, Monique Pedroza, Antonio M.A. Miranda, Teun A.H. van den Brand, Antonio Scialdone, John C. Marioni, Shankar Srinivas
The asymmetric morphology of the mammalian heart is essential to its function as the organ of pulmonary and systemic double circulation. Left-right asymmetry is established by a leftward flow in the node that results in the asymmetric expression ofNo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e03a25765df0b1c2949f9d7848851d5
https://doi.org/10.1101/2022.12.26.521947
https://doi.org/10.1101/2022.12.26.521947