Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ximena, Aguilar"'
Autor:
María Pagnon de la Vega, Stina Syvänen, Vilmantas Giedraitis, Monique Hooley, Evangelos Konstantinidis, Silvio R. Meier, Johanna Rokka, Jonas Eriksson, Ximena Aguilar, Tara L. Spires-Jones, Lars Lannfelt, Lars N. G. Nilsson, Anna Erlandsson, Greta Hultqvist, Martin Ingelsson, Dag Sehlin
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer’s disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation properties of Aβ. We recentl
Externí odkaz:
https://doaj.org/article/e1e6c9096c0f4e3e9f714a2564198215
Autor:
Evangelos Konstantinidis, Agnieszka Molisak, Florian Perrin, Linn Streubel-Gallasch, Sarah Fayad, Daniel Y. Kim, Karl Petri, Martin J. Aryee, Ximena Aguilar, Bence György, Vilmantas Giedraitis, J. Keith Joung, Vikram Pattanayak, Magnus Essand, Anna Erlandsson, Oksana Berezovska, Martin Ingelsson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 450-461 (2022)
Presenilin 1 (PS1) is a central component of γ-secretase, an enzymatic complex involved in the generation of the amyloid-β (Aβ) peptide that deposits as plaques in the Alzheimer’s disease (AD) brain. The M146L mutation in the PS1 gene (PSEN1) le
Externí odkaz:
https://doaj.org/article/503c1c5367834e719f03a069aa99c40b
Autor:
Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fu
Externí odkaz:
https://doaj.org/article/211db83d4d8c4d658f6944fd83ac6f73
Publikováno v:
Monday, April 24.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f47134e6802bb86f3c652c8222bbbf6d
https://doi.org/10.1212/wnl.0000000000202033
https://doi.org/10.1212/wnl.0000000000202033
Autor:
Gillian Bonvicini, Xiaotian T. Fang, Dag Sehlin, Ximena Aguilar, Stina Syvänen, Rebecca Faresjö
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-15 (2021)
Fluids and Barriers of the CNS
Fluids and Barriers of the CNS
Background Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fully under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0047630ad43103367e8351ea058cf9
https://doaj.org/article/211db83d4d8c4d658f6944fd83ac6f73
https://doaj.org/article/211db83d4d8c4d658f6944fd83ac6f73
Publikováno v:
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol XLII-3-W12-2020, Pp 385-388 (2020)
Zooplankton aggregation, hydrographic and remote sensing data were employed to relate the spatial dynamics of neustonic communities with chlorophyll a (Chl a) and suspended organic matter (SOM) at a spatial mesoscale (10 to 1000 km) in the southern C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e2901415c50f032a13addf17f7be9d
https://www.int-arch-photogramm-remote-sens-spatial-inf-sci.net/XLII-3-W12-2020/385/2020/isprs-archives-XLII-3-W12-2020-385-2020.pdf
https://www.int-arch-photogramm-remote-sens-spatial-inf-sci.net/XLII-3-W12-2020/385/2020/isprs-archives-XLII-3-W12-2020-385-2020.pdf
Autor:
Stina Syvänen, Silvio R. Meier, Sahar Roshanbin, Mengfei Xiong, Rebecca Faresjö, Tobias Gustavsson, Gillian Bonvicini, Eva Schlein, Ximena Aguilar, Ulrika Julku, Jonas Eriksson, Dag Sehlin
Positron emission tomography (PET), a medical imaging technique allowing for studies of the living human brain, has gained an important role in clinical trials of novel drugs against Alzheimer’s disease (AD). For example, PET data contributed to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc643bb4a01e26758bf8e39ac35425e
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483631
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483631
Autor:
Evangelos, Konstantinidis, Agnieszka, Molisak, Florian, Perrin, Linn, Streubel-Gallasch, Sarah, Fayad, Daniel Y, Kim, Karl, Petri, Martin J, Aryee, Ximena, Aguilar, Bence, György, Vilmantas, Giedraitis, J Keith, Joung, Vikram, Pattanayak, Magnus, Essand, Anna, Erlandsson, Oksana, Berezovska, Martin, Ingelsson
Publikováno v:
Molecular therapy. Nucleic acids. 28
Presenilin 1 (PS1) is a central component of γ-secretase, an enzymatic complex involved in the generation of the amyloid-β (Aβ) peptide that deposits as plaques in the Alzheimer's disease (AD) brain. The M146L mutation in the PS1 gene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d70b2dc1d4c6ba3973d0c1e6f91804a4
https://pubmed.ncbi.nlm.nih.gov/35505961
https://pubmed.ncbi.nlm.nih.gov/35505961
Autor:
Ximena Aguilar, Jeanette Blomberg, Kristoffer Brännström, Anders Olofsson, Jürgen Schleucher, Stefan Björklund
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98575 (2014)
Mediator is an evolutionary conserved multi-protein complex present in all eukaryotes. It functions as a transcriptional co-regulator by conveying signals from activators and repressors to the RNA polymerase II transcription machinery. The Arabidopsi
Externí odkaz:
https://doaj.org/article/c92256c2113749e6945893ab82e483c9
Publikováno v:
Journal of Alzheimer's Disease
Alzheimer's disease (AD) is the leading cause of dementia worldwide, affecting over 10% of the elderly population. Epidemiological evidence indicates that traumatic brain injury (TBI) is an important risk factor for developing AD later in life. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bc491a439fb913cf11bea10de1e04a
https://pubmed.ncbi.nlm.nih.gov/31561367
https://pubmed.ncbi.nlm.nih.gov/31561367