Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ximei Luo"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract DNA methylation plays a critical role in gene regulation by modulating the DNA binding of transcription factors (TFs). This study integrates TFs’ ChIP-seq profiles with WGBS profiles to investigate how DNA methylation affects protein inter
Externí odkaz:
https://doaj.org/article/2240fd315f0440bb841465427b28811a
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Enhancers play a crucial role in gene regulation, and some active enhancers produce noncoding RNAs known as enhancer RNAs (eRNAs) bi-directionally. The most commonly used method for detecting eRNAs is CAGE-seq, but the instability
Externí odkaz:
https://doaj.org/article/631f9d57332943e2a374f647e39cd215
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1011205 (2023)
DNA methylation is an important regulator of gene transcription. WGBS is the gold-standard approach for base-pair resolution quantitative of DNA methylation. It requires high sequencing depth. Many CpG sites with insufficient coverage in the WGBS dat
Externí odkaz:
https://doaj.org/article/0474e4d7ea0a48c3a29d9ececf9bca41
Publikováno v:
Cancer Medicine, Vol 10, Iss 8, Pp 2703-2713 (2021)
Abstract RNA binding proteins (RBPs) are increasingly appreciated as being essential for normal hematopoiesis and have a critical role in the progression of hematological malignancies. However, their functional consequences and clinical significance
Externí odkaz:
https://doaj.org/article/a20196e96da142089e827680abebdf51
Autor:
Guang Song, Guohua Wang, Ximei Luo, Ying Cheng, Qifeng Song, Jun Wan, Cedric Moore, Hongjun Song, Peng Jin, Jiang Qian, Heng Zhu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Identifying readers of epigenetic marks is a critical step for understanding the role of epigenetic marks in biology. Here, the authors applied DAPPL, an all-to-all approach to profile the interactions between TFs and epigenetic modified DNA librarie
Externí odkaz:
https://doaj.org/article/3c6c0bb7285349ad8d538d0be72b8dfe
Publikováno v:
BMC Genomics, Vol 21, Iss S1, Pp 1-10 (2020)
Abstract Background Methylation of cytosine bases in DNA is a critical epigenetic mark in many eukaryotes and has also been implicated in the development and progression of normal and diseased cells. Therefore, profiling DNA methylation across the ge
Externí odkaz:
https://doaj.org/article/afb521fb188f4856ab219b3059d3a880
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive degeneration of motor neurons. The causative pathogenic mechanisms in ALS remain unclear, limiting the development of treatment strategies. Neu
Externí odkaz:
https://doaj.org/article/46aed2f811534253ae81867bc3486502
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Enhancers are regulatory DNA sequences that could be bound by specific proteins named transcription factors (TFs). The interactions between enhancers and TFs regulate specific genes by increasing the target gene expression. Therefore, enhancer identi
Externí odkaz:
https://doaj.org/article/b93a51f3764a427d91be8ae31d46da61
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
DNA methylation is an important epigenetic mechanism for gene regulation. The conventional view of DNA methylation is that DNA methylation could disrupt protein-DNA interactions and repress gene expression. Several recent studies reported that DNA me
Externí odkaz:
https://doaj.org/article/ed058ba037b7403a8111a50efb2f3551
Autor:
Guang Song, Guohua Wang, Ximei Luo, Ying Cheng, Qifeng Song, Jun Wan, Cedric Moore, Hongjun Song, Peng Jin, Jiang Qian, Heng Zhu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21726-y
Externí odkaz:
https://doaj.org/article/75d454b9e7074b9faadb3f26d5a984a5