Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ximao Wu"'
Publikováno v:
Materials, Vol 7, Iss 4, Pp 2772-2783 (2014)
Oxidation of ferritic/martensitic steel P92 was investigated in pure oxygen and in pure steam at 600–800 °C by thermogravimetric analysis (TGA), optical microscopy (OM), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The results
Externí odkaz:
https://doaj.org/article/22ebf85e61844963b6da0457902eddf7
Autor:
Jacques Y. Roberge, Guixue Yu, Amarendra Mikkilineni, Ximao Wu, Yeheng Zhu, R. Michael Lawrence, William R. Ewing
Publikováno v:
ARKIVOC, Vol 2007, Iss 12, Pp 132-147 (2007)
Externí odkaz:
https://doaj.org/article/354d14f1bfc542a0ac1e7157fd9b7867
Autor:
Gary G. Cao, Min Zhou, Ramya Jayaram, Douglas B. Moore, Andres S. Hernandez, Tao Wang, Jean M. Whaley, Yue-Zhong Shu, Carrie Xu, Lori Kunselman, Atsu Apedo, William R. Ewing, Reshma Panemangalore, Qi Gao, Arvind Mathur, Richard Rampulla, Bradley A. Zinker, Lauren Haque, Mary Ellen Cvijic, Marta Dabros, Arun Kumar Gupta, Heng Liu, Jeffrey A. Robl, Bruce A. Ellsworth, Jun Shi, Zhengxiang Gu, Jason J. Wilkes, Akin H. Davulcu, Kristin N. Williams, Elizabeth A. Dierks, John Krupinski, Zhenqiu Hong, Edward J. Brady, Ximao Wu, Qin Sun, Hong Cai, Chunshan Xie, Elizabeth A. Jurica, Kimberly A. Foster
Publikováno v:
Journal of medicinal chemistry. 61(3)
G protein-coupled receptor 40 (GPR40) has become an attractive target for the treatment of diabetes since it was shown clinically to promote glucose-stimulated insulin secretion. Herein, we report our efforts to develop highly selective and potent GP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbe81ca0de7013eecb9cd7ee4d58d5d
https://pubmed.ncbi.nlm.nih.gov/29316397
https://pubmed.ncbi.nlm.nih.gov/29316397
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode
Autor:
William R. Ewing, Carrie Xu, Heng Liu, Brian J. Murphy, Neil Flynn, Tao Wang, Douglas B. Moore, Lori Kunselman, Bruce A. Ellsworth, Elizabeth A. Jurica, Kimberly A. Foster, Atsu Apedo, Yuan Tian, Yang Hong, Arvind Mathur, Bradley A. Zinker, Biji Jacob, Kristin N. Williams, Min Zhou, Brad D. Maxwell, Gary Cao, Andres S. Hernandez, Qin Sun, Hong Cai, Jean M. Whaley, Elizabeth A. Dierks, Joel C. Barrish, Dora M. Schnur, Ximao Wu, Doree F. Sitkoff, Mary Ellen Cvijic, Richard Rampulla, Chunshan Xie, David S. Nirschl, Reshma Panemangalore, Michael B. Hicks, Jeffrey A. Robl, Jason J. Wilkes
Publikováno v:
Journal of medicinal chemistry. 60(4)
A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by moving the position of the carboxylic acid, a key pharmacophore for GPR40. Addition of a 4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191c75dee9cb5b8c6f860f132f84555d
https://pubmed.ncbi.nlm.nih.gov/28112924
https://pubmed.ncbi.nlm.nih.gov/28112924
Autor:
Kenneth E. Carlson, Olafur S. Gudmundsson, Bruce A. Ellsworth, Philip M. Sher, Susan Harvey, Eva Zuvich, Michael Thomas, William J. Keim, Gang Wu, Helen E. Godonis, Paul Stetsko, Brian J. Murphy, Richard B. Sulsky, Guixue Yu, William R. Ewing, Mary Jane Cullen, Mary Ann Pelleymounter, Doree F. Sitkoff, Susan Johnghar, Zhengxiang Gu, Ximao Wu, James Devenny, Rose Ann F Baska, Asoka Ranasinghe, Ning Lee, Kamelia Behnia, Anthony V. Azzara, Kenneth W. Rohrbach, Gerry Everlof, Liya Kang, Natesan Murugesan, Yeheng Zhu, Yifan Yang
Publikováno v:
Journal of Medicinal Chemistry. 56:9586-9600
Several strategies have been employed to reduce the long in vivo half-life of our lead CB1 antagonist, triazolopyridazinone 3, to differentiate the pharmacokinetic profile versus the lead clinical compounds. An in vitro and in vivo clearance data set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417c836ddf3010c89cd9792afb3349b0
https://doi.org/10.1021/jm4010835
https://doi.org/10.1021/jm4010835
Autor:
Ximao Wu, Guixue Yu, William R. Ewing, Yeheng Zhu, R. Michael Lawrence, Amarendra B. Mikkilineni, Jacques Y. Roberge
Publikováno v:
Scopus-Elsevier
ARKIVOC, Vol 2007, Iss 12, Pp 132-147 (2007)
ARKIVOC, Vol 2007, Iss 12, Pp 132-147 (2007)
Triazolopyridines and triazolopyrimidines were synthesized using a modified Mitsunobu reaction starting from acylated 2-hydrazinopyridines and acylated-hydrazinopyrimidines under mild conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f37e32e591deb9cc55a583871af4da
https://doi.org/10.3998/ark.5550190.0008.c10
https://doi.org/10.3998/ark.5550190.0008.c10
Autor:
Kenneth E. Carlson, Stephen G. Walker, Barry Koplowitz, Kathleen M. Gillooly, John W. Haycock, Kim W. McIntyre, Ximao Wu, Stephen Roberts, Guixue Yu, John E. Macor, George C. Morton, Huji Tuerdi, Yifan Yang, Timothy F. Herpin, R. Michael Lawrence, Liya Kang, Judy Wardwell-Swanson, Ashish Khanna
Publikováno v:
Journal of Leukocyte Biology. 80:897-904
It is well established that melanocortins are peptides that have potent anti-inflammatory activity. Recent research has focused on understanding which of the known melanocortin receptors mediates the anti-inflammatory actions of the melanocortins. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49eae78aadd18c8896ae186501df670d
https://doi.org/10.1189/jlb.1204748
https://doi.org/10.1189/jlb.1204748
Autor:
Kenneth E. Carlson, John S. Tokarski, George C. Morton, R. Michael Lawrence, Guixue Yu, Huji Tuerdi, John E. Macor, Timothy F. Herpin, Ximao Wu, Liya Kang, Ashish Khanna
Publikováno v:
Journal of Medicinal Chemistry. 46:1123-1126
The melanocortin-1 receptor (MC-1R) is a G-protein-coupled receptor involved in inflammation and skin pigmentation. Compound 2 is the first highly potent and selective MC-1R small-molecule agonist reported. Compound 2 showed efficacy in an acute mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27cd19e9c4e3016d60a567ef90ee1f5
https://doi.org/10.1021/jm025600i
https://doi.org/10.1021/jm025600i
Autor:
Laurie Seliger, Jian Wang, Ronald Pongrac, Helen J. Mason, Bruce Beyer, Andrew Henwood, John Krupinski, Ximao Wu, John E. Macor, Saeho Chong, Rongan Zhang, Pam Ferrer, Diane E. Normandin, Guixue Yu, Leonard P. Adam, William G. Humphrey, Bin He
Publikováno v:
Journal of Medicinal Chemistry. 46:457-460
Novel pyrazolopyridopyridazine derivatives have been prepared as potent and selective PDE5 inhibitors. Compound 6 has been identified as a more potent and selective PDE5 inhibitor than sildenafil (1). It is as efficacious as sildenafil in in vitro an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218be77cc0e567028fc0b4f6ba8b9bc2
https://doi.org/10.1021/jm0256068
https://doi.org/10.1021/jm0256068
Autor:
Ximao Wu, Helen J. Mason, Michael Witkus, John E. Macor, William R. Ewing, Guixue Yu, Kim Galdi, Ning Zhao, Cornelius Lyndon A M
Publikováno v:
Synthesis. 2003:0403-0407
Sulfuryl chloride has been used to mono-chlorinate electron-rich arylalkyl- and heteroarylalkyl-amines and amino acids in a mild and efficient one-pot transformation with straightforward purification. Protection of the amines was not needed, and race
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87091f47c8b1447269493f97ce45b2e7
https://doi.org/10.1055/s-2003-37362
https://doi.org/10.1055/s-2003-37362