Výsledky vyhledávání - "Xilal Y. Rima"

Akademický článek

Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis

Publikováno v: Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)

Abstract Detecting pancreatic duct adenocarcinoma (PDAC) in its early stages and predicting late‐stage patient prognosis undergoing chemotherapy is challenging. This work shows that the activation of specific oncogenes leads to elevated expression

Externí odkaz: https://doaj.org/article/a765cae34104438aa7abecd26a692173

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Akademický článek

Arp2/3 complex and the pentose phosphate pathway regulate late phases of neutrophil swarming

Autor: Katharina M. Glaser, Jacob Doon-Ralls, Nicole Walters, Xilal Y. Rima, Angelika S. Rambold, Eduardo Réategui, Tim Lämmermann

Publikováno v: iScience, Vol 27, Iss 1, Pp 108656- (2024)

Summary: Neutrophil swarming is an essential process of the neutrophil response to many pathological conditions. Resultant neutrophil accumulations are hallmarks of acute tissue inflammation and infection, but little is known about their dynamic regu

Externí odkaz: https://doaj.org/article/7a4241ed17e740aa802dd4653ba71d87

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Akademický článek

Exosomal mRNAs for Angiogenic–Osteogenic Coupled Bone Repair

Publikováno v: Advanced Science, Vol 10, Iss 33, Pp n/a-n/a (2023)

Abstract Regenerative medicine in tissue engineering often relies on stem cells and specific growth factors at a supraphysiological dose. These approaches are costly and may cause severe side effects. Herein, therapeutic small extracellular vesicles

Externí odkaz: https://doaj.org/article/be874cc7f6144b73a972bc525c73aa66

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Akademický článek

Engineering a tunable micropattern‐array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ

Publikováno v: Journal of Extracellular Vesicles, Vol 12, Iss 11, Pp n/a-n/a (2023)

Abstract The molecular heterogeneity of extracellular vesicles (EVs) and the co‐isolation of physically similar particles, such as lipoproteins (LPs), confounds and limits the sensitivity of EV bulk biomarker characterization. Herein, we present a

Externí odkaz: https://doaj.org/article/793a6051126e4fb6a8e9f5fa55384db3

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Akademický článek

An immunogold single extracellular vesicular RNA and protein (AuSERP) biochip to predict responses to immunotherapy in non‐small cell lung cancer patients

Autor: Luong T. H. Nguyen, Jingjing Zhang, Xilal Y. Rima, Xinyu Wang, Kwang Joo Kwak, Tamio Okimoto, Joseph Amann, Min Jin Yoon, Takehito Shukuya, Chi‐Ling Chiang, Nicole Walters, Yifan Ma, Donald Belcher, Hong Li, Andre F. Palmer, David P. Carbone, L. James Lee, Eduardo Reátegui

Publikováno v: Journal of Extracellular Vesicles, Vol 11, Iss 9, Pp n/a-n/a (2022)

Abstract Conventional PD‐L1 immunohistochemical tissue biopsies only predict 20%–40% of non‐small cell lung cancer (NSCLC) patients that will respond positively to anti‐PD‐1/PD‐L1 immunotherapy. Herein, we present an immunogold biochip to

Externí odkaz: https://doaj.org/article/146b93eb927b403f95099c23ef145b70

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Akademický článek

Analyzing Inter-Leukocyte Communication and Migration In Vitro: Neutrophils Play an Essential Role in Monocyte Activation During Swarming

Autor: Nicole Walters, Jingjing Zhang, Xilal Y. Rima, Luong T. H. Nguyen, Ronald N. Germain, Tim Lämmermann, Eduardo Reátegui

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Neutrophils are known to be the first responders to infection or injury. However, as inflammation progresses, other leukocytes become increasingly important in inflammation propagation, tissue reconstruction, and inflammation resolution. In recent ye

Externí odkaz: https://doaj.org/article/7ed7a5c99e9047818cbc591b4cef324a

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Abstract P2-16-05: Targeting EZH2 to overcome chemoresistance in Triple Negative Breast Cancers Employing Combinatorial Approach

Autor: Eswar Shankar, Sridhar SNC, Xilal Y. Rima, Prem Kushwaha, Shiv Verma, Gautam K. Sarathy, Anagh kulkarni, Dharmaraja Allimuthu, Eduardo Reátegui, Sanjay Gupta, Bhuvaneswari Ramaswamy

Publikováno v: Cancer Research. 83:P2-16

Objective: Triple Negative Breast Cancers (TNBC) are highly invasive and 46% of patients develop distant metastases, leading to higher mortality. Chemotherapy remains the most efficacious option, however, there is still a largely unmet need to identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::840cd67fddd95234bde2291c3fa11e90
https://doi.org/10.1158/1538-7445.sabcs22-p2-16-05

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Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis

Autor: Xilal Y. Rima, Jingjing Zhang, Luong T. H. Nguyen, Aaron Rajasuriyar, Min Jin Yoon, Chi-Ling Chiang, Nicole Walters, Kwang Joo Kwak, L. James Lee, Eduardo Reátegui

Publikováno v: Lab Chip

Investigating cellular and vesicular heterogeneity in breast cancer remains a challenge, which encourages the development of controllable in vitro systems that mimic the tumor microenvironment. Although three-dimensional cell culture better recapitul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925415febe5b32f2dbc8d233a63e3afe
https://doi.org/10.1039/d1lc01053k

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