Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Xikun Han"'
Autor:
Connor J. Greatbatch, MBBS, Qinyi Lu, MD, PhD, Sandy Hung, PhD, Son N. Tran, PhD, Kristof Wing, MBBS, Helena Liang, MD, PhD, Xikun Han, PhD, Tiger Zhou, FRANZCO, PhD, Owen M. Siggs, MD, PhD, David A. Mackey, FRANZCO, MD, Guei-Sheung Liu, PhD, Anthony L. Cook, PhD, Joseph E. Powell, PhD, Jamie E. Craig, FRANZCO, DPhil, Stuart MacGregor, PhD, Alex W. Hewitt, FRANZCO, PhD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 4, Pp 100504- (2024)
Purpose: Genome-wide association studies have recently uncovered many loci associated with variation in intraocular pressure (IOP). Artificial intelligence (AI) can be used to interrogate the effect of specific genetic knockouts on the morphology of
Externí odkaz:
https://doaj.org/article/abb1ee8966924ea990c570465f440c02
Autor:
Jue-Sheng Ong, Mathias Seviiri, Jean Claude Dusingize, Yeda Wu, Xikun Han, Jianxin Shi, Catherine M. Olsen, Rachel E. Neale, John F. Thompson, Robyn P. M. Saw, Kerwin F. Shannon, Graham J. Mann, Nicholas G. Martin, Sarah E. Medland, Scott D. Gordon, Richard A. Scolyer, Georgina V. Long, Mark M. Iles, Maria Teresa Landi, David C. Whiteman, Stuart MacGregor, Matthew H. Law
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Male-pattern baldness (MPB) is related to dysregulation of androgens such as testosterone. A previously observed relationship between MPB and skin cancer may be due to greater exposure to ultraviolet radiation or indicate a role for androgen
Externí odkaz:
https://doaj.org/article/104552cdb9d144b6866af7b840d364e2
Autor:
Ines Lains, MD, PhD, Xikun Han, PhD, João Gil, MD, Joana Providencia, MD, Archana Nigalye, MD, Rodrigo Alvarez, MD, Vivian Paraskevi Douglas, MD, Kevin Mendez, MSc, Raviv Katz, BSc, Gregory Tsougranis, BSc, Jinglun Li, BSc, Rachel S. Kelly, PhD, Ivana K. Kim, MD, Jessica Lasky-Su, ScD, Rufino Silva, MD, PhD, Joan W. Miller, MD, Liming Liang, PhD, Demetrios Vavvas, MD, PhD, John B. Miller, MD, Deeba Husain, MD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 1, Pp 100357- (2024)
Purpose: The most widely used classifications of age-related macular degeneration (AMD) and its severity stages still rely on color fundus photographs (CFPs). However, AMD has a wide phenotypic variability that remains poorly understood and is better
Externí odkaz:
https://doaj.org/article/f85fa775aca54aa681cfe9965278b9bf
Autor:
Xikun Han, Zhaozhong Zhu, Qian Xiao, Jun Li, Xiumei Hong, Xiaobin Wang, Kohei Hasegawa, Carlos A. Camargo, Liming Liang
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
A comprehensive genetic analysis of the relationship between childhood obesity and childhood asthma identifies shared mechanisms and potential mediators linking the two pediatric disorders.
Externí odkaz:
https://doaj.org/article/bbe3ecd484d545ce9690dbf74d3b98ce
Autor:
Anne Senabouth, Maciej Daniszewski, Grace E. Lidgerwood, Helena H. Liang, Damián Hernández, Mehdi Mirzaei, Stacey N. Keenan, Ran Zhang, Xikun Han, Drew Neavin, Louise Rooney, Maria Isabel G. Lopez Sanchez, Lerna Gulluyan, Joao A. Paulo, Linda Clarke, Lisa S. Kearns, Vikkitharan Gnanasambandapillai, Chia-Ling Chan, Uyen Nguyen, Angela M. Steinmann, Rachael A. McCloy, Nona Farbehi, Vivek K. Gupta, David A. Mackey, Guy Bylsma, Nitin Verma, Stuart MacGregor, Matthew J. Watt, Robyn H. Guymer, Joseph E. Powell, Alex W. Hewitt, Alice Pébay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Age-related macular degeneration (AMD) is a leading cause of vision loss, and there is no approved treatment for AMD with geographic atrophy. Here, the authors used transcriptomic and proteomic analyses of patient induced pluripotent stem cell-derive
Externí odkaz:
https://doaj.org/article/26ee70153c844e808b5ef6d67e2ac7a9
Autor:
Xikun Han, Samantha Sze-Yee Lee, Nathan Ingold, Nigel McArdle, Anthony P. Khawaja, Stuart MacGregor, David A. Mackey
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Sleep apnoea, a common sleep-disordered breathing condition, is characterised by upper airway collapse during sleep resulting in transient hypoxia, hypoperfusion of the optic nerve, and spike in intracranial pressure. Previous stu
Externí odkaz:
https://doaj.org/article/187c834ef29248b0a7fcca9d2d0f6692
Autor:
Maciej Daniszewski, Anne Senabouth, Helena H. Liang, Xikun Han, Grace E. Lidgerwood, Damián Hernández, Priyadharshini Sivakumaran, Jordan E. Clarke, Shiang Y. Lim, Jarmon G. Lees, Louise Rooney, Lerna Gulluyan, Emmanuelle Souzeau, Stuart L. Graham, Chia-Ling Chan, Uyen Nguyen, Nona Farbehi, Vikkitharan Gnanasambandapillai, Rachael A. McCloy, Linda Clarke, Lisa S. Kearns, David A. Mackey, Jamie E. Craig, Stuart MacGregor, Joseph E. Powell, Alice Pébay, Alex W. Hewitt
Publikováno v:
Cell Genomics, Vol 2, Iss 6, Pp 100142- (2022)
Summary: To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retin
Externí odkaz:
https://doaj.org/article/bda5107c7c8a45e0aa69bcd697f93428
Autor:
Amy V. Jones, PhD, Stuart MacGregor, PhD, Xikun Han, PhD, James Francis, PhD, Claire Harris, PhD, David Kavanagh, MD, PhD, Andrew Lotery, MD, FRCOphth, Nadia Waheed, MD, MPH
Publikováno v:
Ophthalmology Science, Vol 2, Iss 2, Pp 100146- (2022)
Purpose: Risk of advanced age-related macular degeneration (AAMD) is associated with rare genetic variants in the gene encoding complement factor I (CFI), which is associated with lower circulating CFI protein levels, but the nature of the relationsh
Externí odkaz:
https://doaj.org/article/6f0924b96d7b479a9ab9ee7cd4da9c62
Autor:
Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass, Xikun Han, Jue Sheng Ong, Alex W. Hewitt, Ayellet V. Segrè, John M. Rouhana, Andrew R. Hamel, Robert P. Igo, Helene Choquet, Ayub Qassim, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Adriana Iglesias, Owen M. Siggs, Terri L. Young, Veronique Vitart, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, Mark Simcoe, Nishani Amersinghe, Angela J. Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi-Song Rong, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, GIGA study group, and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk l
Externí odkaz:
https://doaj.org/article/ea46188f0f2c4f0cae58f959caf971a2
Autor:
Jue-Sheng Ong, Suzanne C. Dixon-Suen, Xikun Han, Jiyuan An, Esophageal Cancer Consortium, and Me Research Team, Upekha Liyanage, Jean-Cluade Dusingize, Johannes Schumacher, Ines Gockel, Anne Böhmer, Janusz Jankowski, Claire Palles, Tracy O’Mara, Amanda Spurdle, Matthew H. Law, Mark M. Iles, Paul Pharoah, Andrew Berchuck, Wei Zheng, Aaron P. Thrift, Catherine Olsen, Rachel E. Neale, Puya Gharahkhani, Penelope M. Webb, Stuart MacGregor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data
Externí odkaz:
https://doaj.org/article/7744806243e1477e9baddee9305b938e