Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Xifu Liang"'
Autor:
Malene Bertelsen, Kristoffer Månsson, Thomas Högberg, Anke Soor, Morten Dahl Sørensen, Gunnar Grue-Sørensen, Karen Margrethe Engell, Martin Stahlhut, Per Vedsø, Xifu Liang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:54-60
Ingenol 3-benzoates were investigated with respect to chemical stability, pro-inflammatory effects, cell death induction and PKCδ activation. A correlation between structure, chemical stability and biological activity was found and compared to ingen
Autor:
Karen Margrethe Engell, Kristoffer Månsson, Martin Stahlhut, Malene Bertelsen, Xifu Liang, Gunnar Grue-Sørensen, Thomas Högberg, Anke Soor, Per Vedsø
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5624-5629
Ingenol mebutate is the active ingredient in Picato® a new drug for the treatment of actinic keratosis. A number of derivatives related to ingenol mebutate were prepared by chemical synthesis from ingenol with the purpose of investigating the SAR an
Semisynthesis of Ingenol 3-Angelate (PEP005): Efficient Stereoconservative Angeloylation of Alcohols
Publikováno v:
Synlett. 23:2647-2652
A high-yielding method was developed for the preparation of ingenol 3-angelate (PEP005, ingenol mebutate) via the corresponding 5,20-acetonide without concomitant isomerization of the angelate (Z-form) to the corresponding tiglate (E-form). The gener
Publikováno v:
Lillelund, V H, Liu, H, Liang, X, Søhoel, H & Bols, M 2003, ' Isofagomine lactams, synthesis and enzyme inhibition ', Organic & Biomolecular Chemistry, vol. 1, pp. 282-287 .
The synthesis of isofagomine lactams (2-oxoisofagomines) corresponding to the biologically important hexoses is presented. The D-glucose/D-mannose analogue (3S,4R,5R)-3,4-dihydroxy-5-hydroxymethylpiperidin-2-one (9) was synthesised in 9 steps from D-
Publikováno v:
Chemical Reviews. 102:515-554
Autor:
Mikael Bols, Xifu Liang
Publikováno v:
Liang, X & Bols, M 2002, ' Solution-Phase Combinatorial Synthesis using Multicomponent Grignard reagents ', Journal of the Chemical Society, Perkin Transactions 1, pp. 503-508 .
Mixtures of up to 8 different alkyl Grignard reagents were prepared from the reaction of alkyl halides with magnesium. These multicomponent Grignard reagents were reacted with aldehydes, ketones or esters to produce mixtures of alcohols. Analysis of
Publikováno v:
Liang, X, Petersen, B O, Duus, J & Bols, M 2001, ' A Bioisosteric Oligosaccharide Mimetic based on Isofagomine-type Monomers ', J. Chem. Soc. Perkin 1, pp. 2764-2773 .
A series of hydroxylated piperidine oligomers that resemble oligosaccharides is synthesised. Prepared were 5, a mimic of 3-O-L-fucopyranosyl-D-galactopyranose, 6, a mimic of 3-O-D-galactopyranosyl-D-galactopyranose and 7, a mimic of 3-O-{3-O-[3-O-(L-
Publikováno v:
Søndergaard, K, Liang, X & Bols, M 2001, ' Synthesis of 5-Azacastanospermine, a conformationally restricted azafagomine analogue ', Chemistry: A European Journal, vol. 7, pp. 2324-2331 .
The 5-aza-6-deoxy analogue of castanospermine (+/-)-5a and its 1-epimer (+/-)-5b was synthesized. The synthesis started from the known compound 5-benzyloxy-7-hydroxyhepta-1,3-diene, which was protected and subjected to Diels-Alder reaction with 4-phe
Autor:
Bettina V. Ernholt, Anders Lohse, Rita G. Hazell, I. Thomsen, Xifu Liang, Mikael Bols, Astrid Jakobsen, Igor W. Plesner, Kenneth B. Jensen
Publikováno v:
Chemistry - A European Journal. 6:278-287
For the first time the two enantiomeric forms of the glycosidase inhibitor 1-azafagomine have been synthesised starting from D- and L-xylose. D-Xylose was converted to the 2,3,5-tribenzylfuranose, which upon reductive amination with tert-butyl carbaz
Autor:
Mikael Bols, Xifu Liang
Publikováno v:
The Journal of Organic Chemistry. 64:8485-8488
A new chemoenzymatic synthesis of both enantiomeric forms of the glycosidase inhibitor 1-azafagomine (1) is reported. The synthesis starts from the achiral starting materials pentadienol and methylurazol with the key steps being a hetero-Diels−Alde