Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Xiexie, Liu"'
Publikováno v:
Human Gene Therapy. 30:673-681
Traditional gene therapy (gene replacement) has made a breakthrough in treating inherited diseases. Adeno-associated virus (AAV) has emerged as a highly promising vector with innate ability, boosting the development of gene replacement and gene targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29985a989641a057179aceb92bcd70f0
https://doi.org/10.1089/hum.2018.190
https://doi.org/10.1089/hum.2018.190
Autor:
Xiaoyu Liu, Dingbo Zhang, Feng Gu, Xiexie Liu, Fayu Yang, Yong Liu, Lingkai Gu, Haihua Xie, Qianwen Ren, Caixia Gao, Yufei Wang, Bang Wang, Xiubin He, Tianyuan Zhao
Publikováno v:
Journal of Biological Chemistry. 294:9308-9315
CRISPR/Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. High-fidelity Cas9 variants have been identified; however, they often have reduced activity, constraining their utility, which presents a major cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eacfc8c56188080d78b4d1f313224973
https://doi.org/10.1074/jbc.ra119.007791
https://doi.org/10.1074/jbc.ra119.007791
Autor:
Zongming Song, Xiexie Liu, Ji-Neng Lv, Xiaoyu Liu, Junzhao Zhao, Haihua Xie, Chenchen Zhou, Yuanyuan Liu, Bang Wang, Xiubin He, Yong Liu, Xiujuan Lv, Mingchun Li, Feng Gu, Lianchao Tang, Changbao Liu
Publikováno v:
The Journal of Biological Chemistry
Clustered regularly interspaced short palindromic repeat–Cas12a has been harnessed to manipulate the human genome; however, low cleavage efficiency and stringent protospacer adjacent motif hinder the use of Cas12a-based therapy and applications. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7595f67ca5aefcb1841f84fec2c1f167
http://europepmc.org/articles/PMC7961096
http://europepmc.org/articles/PMC7961096
Autor:
Xiubin, He, Yufei, Wang, Fayu, Yang, Bang, Wang, Haihua, Xie, Lingkai, Gu, Tianyuan, Zhao, Xiexie, Liu, Dingbo, Zhang, Qianwen, Ren, Xiaoyu, Liu, Yong, Liu, Caixia, Gao, Feng, Gu
Publikováno v:
J Biol Chem
CRISPR/Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. High-fidelity Cas9 variants have been identified; however, they often have reduced activity, constraining their utility, which presents a major cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6871e9e8f5851738d0c6abc56308d3bf
https://pubmed.ncbi.nlm.nih.gov/31010827
https://pubmed.ncbi.nlm.nih.gov/31010827
Autor:
Zongming Song, Xianglian Ge, Junzhao Zhao, Jia Qu, Junsong Zhang, Fayu Yang, Xiexie Liu, Xiubin He, Chenchen Zhou, Changbao Liu, Feng Gu, Huihui Sun
Publikováno v:
Journal of genetics and genomics = Yi chuan xue bao.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1817e51b0dc4a2f23285711352188d6c
https://pubmed.ncbi.nlm.nih.gov/29929850
https://pubmed.ncbi.nlm.nih.gov/29929850
Autor:
Xiexie Liu1, Xiaoyu Liu1, Chenchen Zhou1, Jineng Lv1, Xiubin He1, Yuanyuan Liu1, Haihua Xie1, Bang Wang1, Xiujuan Lv1, Lianchao Tang1, Mingchun Li1, Changbao Liu2, Junzhao Zhao2, Yong Liu1, Zongming Song1,3, Feng Gu1 gufenguw@gmail.com
Publikováno v:
Journal of Biological Chemistry. Jan-Jun2021, Vol. 296, p1-10. 10p.
Autor:
Qianwen Ren, Xiujuan Lv, Jin Li, Junzhao Zhao, Fanfan Li, Feng Gu, Bang Wang, Xiubin He, Yufei Wang, Haihua Xie, Ruzhi Deng, Zongming Song, Xiexie Liu, Congsheng Cheng
Publikováno v:
Biotechnology Journal. 14:1800689
Genome editing using RNA-guided nucleases in their ribonucleoprotein (RNP) form represents a promising strategy for gene modification and therapy because they are free of exogenous DNA integration and have reduced toxicity in vivo and ex vivo. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b032aebd5d630398ef99e19314a0020
https://doi.org/10.1002/biot.201800689
https://doi.org/10.1002/biot.201800689
Autor:
Junjie Liu, Xiubin He, Xianglian Ge, Jin Li, Junzhao Zhao, Jia Qu, Chenchen Zhou, Haihua Xie, Lianchao Tang, Changbao Liu, Feng Gu, Zongming Song, Xiexie Liu
Publikováno v:
Biotechnology Journal. 13:1800080
CRISPR/Cas9-mediated gene therapy holds great promise for the treatment of human diseases. The protospacer adjacent motif (PAM), the sequence adjacent to the target sequence, is an essential targeting component for the design of CRISPR/Cas9-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2604d25b13714f4d59a137e1bfce8e60
https://doi.org/10.1002/biot.201800080
https://doi.org/10.1002/biot.201800080