Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Xiemin Cao"'
Autor:
Leticia Forny Germano, Jacqueline A. Koehler, Laurie L. Baggio, Fiona Cui, Chi Kin Wong, Nikolaj Rittig, Xiemin Cao, Dianne Matthews, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102019- (2024)
Objective: The development of glucagon-like peptide-1 receptor (GLP-1R) agonists for the treatment of type 2 diabetes and obesity has been accompanied by evidence for anti-inflammatory and cytoprotective actions in the heart, blood vessels, kidney, a
Externí odkaz:
https://doaj.org/article/251c6b672668429ebb6e64cd03609235
Autor:
Gemma Pujadas, Laurie L. Baggio, Kiran Deep Kaur, Brent A. McLean, Xiemin Cao, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101586- (2022)
Objective: The gut hormone glucose-dependent insulinotropic polypeptide (GIP) stimulates beta cell function and improves glycemia through its incretin actions. GIP also regulates endothelial function and suppresses adipose tissue inflammation through
Externí odkaz:
https://doaj.org/article/7e70eb06308240b68752d72f802653ba
Autor:
Laurie L. Baggio, Elodie M. Varin, Jacqueline A. Koehler, Xiemin Cao, Yuliya Lokhnygina, Susanna R. Stevens, Rury R. Holman, Daniel J. Drucker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
DPP4 inhibitors are used for the treatment of diabetes, but the impact of DPP4 activity and soluble DPP4 on development of diabetes-associated inflammation remains uncertain. Here the authors study whether DPP4 inhibition controls sDPP4 and inflammat
Externí odkaz:
https://doaj.org/article/cfbe57d96821439588f72940834dce14
Autor:
Kiran Deep Kaur, Chi Kin Wong, Laurie L. Baggio, Jacqueline L. Beaudry, Shai Fuchs, Brandon L. Panaro, Dianne Matthews, Xiemin Cao, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101213- (2021)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) and Glucagon-like peptide-1 (GLP-1) are incretin hormones that exert overlapping yet distinct actions on islet β-cells. We recently observed that GIP, but not GLP-1, upregulated islet exp
Externí odkaz:
https://doaj.org/article/912c0af51d7541668866e9c08d11779d
Autor:
Jacqueline L. Beaudry, Kiran D. Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Holly E. Bates, Jonathan E. Campbell, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 28, Iss , Pp 14-25 (2019)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism. Loss or attenuation of GIP receptor (GIPR) action leads to re
Externí odkaz:
https://doaj.org/article/74333548414145d59b6704366a4af522
Autor:
Jacqueline L. Beaudry, Kiran Deep Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Jennifer H. Stern, Jonathan E. Campbell, Phillip E. Scherer, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 22, Iss , Pp 37-48 (2019)
Objective: Administration of glucagon (GCG) or GCG-containing co-agonists reduces body weight and increases energy expenditure. These actions appear to be transduced by multiple direct and indirect GCG receptor (GCGR)-dependent mechanisms. Although t
Externí odkaz:
https://doaj.org/article/34b08743c20a4fa3babce0d5ea0b6b24
Autor:
Elodie M. Varin, Antonio A. Hanson, Jacqueline L. Beaudry, My-Anh Nguyen, Xiemin Cao, Laurie L. Baggio, Erin E. Mulvihill, Daniel J. Drucker
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Postprandial triglycerides (TGs) are elevated in people with type 2 diabetes (T2D). Glucose-lowering agents, such as glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, also reduce postprandial TG excursio
Externí odkaz:
https://doaj.org/article/e1f3441765654638b3479d74a6662d27
Autor:
Laurie L. Baggio, John R. Ussher, Brent A. McLean, Xiemin Cao, M. Golam Kabir, Erin E. Mulvihill, Alexandra S. Mighiu, Hangjun Zhang, Andreas Ludwig, Randy J. Seeley, Scott P. Heximer, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1339-1349 (2017)
Objectives: Glucagon-like peptide-1 (GLP-1) is secreted from enteroendocrine cells and exerts a broad number of metabolic actions through activation of a single GLP-1 receptor (GLP-1R). The cardiovascular actions of GLP-1 have garnered increasing att
Externí odkaz:
https://doaj.org/article/303b70b90ae24e40b83a7a0d0faa7c9d
Autor:
Elodie M. Varin, Erin E. Mulvihill, Laurie L. Baggio, Jacqueline A. Koehler, Xiemin Cao, Randy J. Seeley, Daniel J. Drucker
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3371-3384.e3 (2019)
Summary: Glucagon-like peptide 1 (GLP-1) receptors are widely distributed throughout the nervous system, enabling physiological and pharmacological control of glucose and energy homeostasis. Here we elucidated the importance of Glp1r expression withi
Externí odkaz:
https://doaj.org/article/25736fd6cd4a4692ba6d620be217cfe1
Autor:
Xiemin Cao, Jonathan E. Campbell, Kirandeep Kaur, Jacqueline L. Beaudry, Erin E. Mulvihill, Laurie L. Baggio, Elodie M. Varin, Holly E. Bates, Daniel J. Drucker
Publikováno v:
Molecular Metabolism, Vol 28, Iss, Pp 14-25 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Glucose-dependent insulinotropic polypeptide (GIP) is secreted from the gut in response to nutrient ingestion and promotes meal-dependent insulin secretion and lipid metabolism. Loss or attenuation of GIP receptor (GIPR) action leads to res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90e657812a626025c58aad5924a1cff
http://www.sciencedirect.com/science/article/pii/S2212877819306179
http://www.sciencedirect.com/science/article/pii/S2212877819306179