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Structural surfaceomics reveals an AML-specific conformation of integrin β 2 as a CAR T cellular therapy target.

Autor: Mandal K; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Wicaksono G; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Yu C; Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA., Adams JJ; The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada., Hoopmann MR; Institute for Systems Biology, Seattle, WA, USA., Temple WC; Department of Pediatrics, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA.; Department of Pediatrics, Division of Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, CA, USA., Izgutdina A; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Escobar BP; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Gorelik M; The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada., Ihling CH; Department of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Halle, Germany., Nix MA; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Naik A; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Xie WH; UCSF/Gladstone Institute for Genomic Immunology, San Francisco, CA, USA., Hübner J; Department of Pediatrics, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Rollins LA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital-Texas Children's Hospital, Houston, TX, USA., Reid SM; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital-Texas Children's Hospital, Houston, TX, USA., Ramos E; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Kasap C; Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA., Steri V; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Serrano JAC; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Salangsang F; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Phojanakong P; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., McMillan M; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Gavallos V; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Leavitt AD; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Logan AC; Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA., Rooney CM; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital-Texas Children's Hospital, Houston, TX, USA., Eyquem J; UCSF/Gladstone Institute for Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA., Sinz A; Department of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Martin-Luther University Halle-Wittenberg, Halle, Germany., Huang BJ; Department of Pediatrics, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA., Stieglitz E; Department of Pediatrics, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Smith CC; Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA, USA., Moritz RL; Institute for Systems Biology, Seattle, WA, USA., Sidhu SS; The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada., Huang L; Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA., Wiita AP; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA. arun.wiita@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. arun.wiita@ucsf.edu.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. arun.wiita@ucsf.edu.; Chan Zuckerberg Biohub San Francisco, San Francisco, CA, USA. arun.wiita@ucsf.edu.

Publikováno v: Nature cancer [Nat Cancer] 2023 Nov; Vol. 4 (11), pp. 1592-1609. Date of Electronic Publication: 2023 Oct 30.