Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Xichen Nie"'
Autor:
Xiaojian Lu, Yanwei Luo, Xichen Nie, Bailing Zhang, Xiaoyan Wang, Ran Li, Guangmin Liu, Qianyin Zhou, Zhizhong Liu, Liqing Fan, James M. Hotaling, Zhe Zhang, Hao Bo, Jingtao Guo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Seminoma is the most common malignant solid tumor in 14 to 44 year-old men. However, its molecular features and tumor microenvironment (TME) is largely unexplored. Here, we perform a series of studies via genomics profiling (single cell mult
Externí odkaz:
https://doaj.org/article/67bd7d360de14f048528c4e2d4339c3c
Autor:
Graham JM Hickey, Candice L Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J Murphy, Bradley R Cairns
Publikováno v:
eLife, Vol 11 (2022)
Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal the order of chromatin
Externí odkaz:
https://doaj.org/article/0f077f5c7e104e5a86be865a70d5caec
Autor:
Danni Deng, Kaiming Luo, Hongmei Liu, Xichen Nie, Lian Xue, Rong Wang, Yuan Xu, Jun Cui, Naiyuan Shao, Feng Zhi
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized. Methods We examined
Externí odkaz:
https://doaj.org/article/fd13fae8e1fb4b158695e3710f3a4673
Autor:
Haiqi Chen, Evan Murray, Anubhav Sinha, Anisha Laumas, Jilong Li, Daniel Lesman, Xichen Nie, Jim Hotaling, Jingtao Guo, Bradley R. Cairns, Evan Z. Macosko, C. Yan Cheng, Fei Chen
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109915- (2021)
Summary: Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs governing mammalian spermatogenesis but fails to delineate their dynamics in the native context of seminiferous tubules, the spatially confined functional
Externí odkaz:
https://doaj.org/article/a14b6b9f7c6f49fcbea7513571e4a8d5
Autor:
Kunpeng Liu, Chuanxia Zhang, Bowen Li, Weihong Xie, Jindong Zhang, Xichen Nie, Peng Tan, Limin Zheng, Song Wu, Yunfei Qin, Jun Cui, Feng Zhi
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 838-851 (2018)
Summary: p38 signaling is broadly involved in controlling inflammation and stress-induced cell death; however, the mechanisms controlling its activity have seldom been studied. Here, we report that TRIM9 short isoform (TRIM9s) potentiates p38 signali
Externí odkaz:
https://doaj.org/article/7ccbf82e58d34fb896efc1dd3eadc8fa
Autor:
Xichen Nie, Sarah K. Munyoki, Meena Sukhwani, Nina Schmid, Annika Missel, Benjamin R. Emery, Donor Connect, Jan-Bernd Stukenborg, Artur Mayerhofer, Kyle E. Orwig, Kenneth I. Aston, James M. Hotaling, Bradley R. Cairns, Jingtao Guo
SUMMARYAging human males display reduced reproductive health, however testis aging is poorly understood at the molecular and genomic level. Here, we utilized single-cell RNA-seq to profile over 44,000 cells from both young and older men (>60 years ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62aa0dc889987460e4ef0da9e995d8e6
https://doi.org/10.1101/2021.10.19.464550
https://doi.org/10.1101/2021.10.19.464550
Comparative single-cell analysis of biopsies clarifies pathogenic mechanisms in Klinefelter syndrome
Autor:
Jingtao Guo, Katinka Vigh-Conrad, Donald F. Conrad, Nicole B. Rockweiler, Eisa Mahyari, Ana C. Lima, Liina Nagirnaja, James M. Hotaling, Daniel P. Lewinsohn, Douglas T. Carrell, Xichen Nie, Kenneth I. Aston, Alexandra M. Stendahl
Publikováno v:
Am J Hum Genet
Summary Klinefelter syndrome (KS), also known as 47, XXY, is characterized by a distinct set of physiological abnormalities, commonly including infertility. The molecular basis for Klinefelter-related infertility is still unclear, largely because of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9089d7cc3ef8dd2c1fe01fa98c6c1c59
https://europepmc.org/articles/PMC8546046/
https://europepmc.org/articles/PMC8546046/
Autor:
Xichen Nie, Sarah K. Munyoki, Meena Sukhwani, Nina Schmid, Annika Missel, Benjamin R. Emery, null DonorConnect, Jan-Bernd Stukenborg, Artur Mayerhofer, Kyle E. Orwig, Kenneth I. Aston, James M. Hotaling, Bradley R. Cairns, Jingtao Guo
Publikováno v:
Dev Cell
Aging men display reduced reproductive health; however, testis aging is poorly understood at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over 44,000 cells from both young and older men and examined age-related c
Autor:
Graham JM Hickey, Candice L Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J Murphy, Bradley R Cairns
Publikováno v:
eLife
eLife, Vol 11 (2022)
eLife, Vol 11 (2022)
Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal the order of chromatin