Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Xichen Lian"'
Autor:
Mingkun Lu, Jiayi Yin, Qi Zhu, Gaole Lin, Minjie Mou, Fuyao Liu, Ziqi Pan, Nanxin You, Xichen Lian, Fengcheng Li, Hongning Zhang, Lingyan Zheng, Wei Zhang, Hanyu Zhang, Zihao Shen, Zhen Gu, Honglin Li, Feng Zhu
Publikováno v:
Engineering, Vol 27, Iss , Pp 37-69 (2023)
Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market. However, investments in a new drug often go unrewarded due to the long and complex process of drug research and development (R&
Externí odkaz:
https://doaj.org/article/c88b2068497d4c27a2c6926448529a3f
Publikováno v:
Advanced Science, Vol 10, Iss 15, Pp n/a-n/a (2023)
Abstract ANPELA is widely used for quantifying traditional bulk proteomic data. Recently, there is a clear shift from bulk proteomics to the single‐cell ones (SCP), for which powerful cytometry techniques demonstrate the fantastic capacity of captu
Externí odkaz:
https://doaj.org/article/e4f7588ce99a40a79d25495d9a41a8ba
Autor:
Feng Zhu, Yu Zong Chen, Yunqing Qiu, Fengcheng Li, Chaoxin Wang, Ying Zhou, Yintao Zhang, Xichen Lian
Publikováno v:
Nucleic Acids Research
Drug discovery relies on the knowledge of not only drugs and targets, but also the comparative agents and targets. These include poor binders and non-binders for developing discovery tools, prodrugs for improved therapeutics, co-targets of therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50e7cc3aa4106a17d96864f8a50efab
https://doi.org/10.1093/nar/gkab953
https://doi.org/10.1093/nar/gkab953
Autor:
Xueni Sun, Jianxin Wang, Ting Jin, Ying Zhou, Xinbing Sui, Zimao Liang, Wenqi Qiu, Ting Pan, Lili Yan, Han Xie, Feng Zhu, Yintao Zhang, Zhaorong Li, Xichen Lian
Publikováno v:
Nucleic Acids Research
Natural product (NP) has a long history in promoting modern drug discovery, which has derived or inspired a large number of currently prescribed drugs. Recently, the NPs have emerged as the ideal candidates to combine with other therapeutic strategie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0074983abfb477218194e3b6fa9831
http://europepmc.org/articles/PMC8728151
http://europepmc.org/articles/PMC8728151
Autor:
Hongyan Yu, Binbin Xu, Jianxin Wang, Wenqi Qiu, Feng Zhu, Xiaona Wang, Zhaorong Li, Xichen Lian, Fengcheng Li, Weiwei Xue, Yanlin Li, Zhao Zhang
Publikováno v:
Nucleic Acids Research
The success of protein engineering and design has extensively expanded the protein space, which presents a promising strategy for creating next-generation proteins of diverse functions. Among these proteins, the synthetic binding proteins (SBPs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a50391f7953899c1e5cccd440651ed
http://europepmc.org/articles/PMC8728148
http://europepmc.org/articles/PMC8728148
Autor:
Chenyang Zhang, Minjie Mou, Ying Zhou, Wei Zhang, Xichen Lian, Shuiyang Shi, Mingkun Lu, Huaicheng Sun, Fengcheng Li, Yunxia Wang, Zhenyu Zeng, Zhaorong Li, Bing Zhang, Yunqing Qiu, Feng Zhu, Jianqing Gao
Publikováno v:
Briefings in bioinformatics. 23(5)
In a drug formulation (DFM), the major components by mass are not Active Pharmaceutical Ingredient (API) but rather Drug Inactive Ingredients (DIGs). DIGs can reach much higher concentrations than that achieved by API, which raises great concerns abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83743c14cfcc48619b9ea33f4e14887
https://pubmed.ncbi.nlm.nih.gov/35524477
https://pubmed.ncbi.nlm.nih.gov/35524477
Publikováno v:
Journal of Molecular Biology. :167944
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::136ee541c02e4317499ebb0457454285
https://doi.org/10.1016/j.jmb.2022.167944
https://doi.org/10.1016/j.jmb.2022.167944
Publikováno v:
Briefings in Bioinformatics. 22
Individual variations in drug efficacy, side effects and adverse drug reactions are still challenging that cannot be ignored in drug research and development. The aim of pharmacometabonomics is to better understand the pharmacokinetic properties of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78800b11a219365016e3c59456cc593
https://doi.org/10.1093/bib/bbab138
https://doi.org/10.1093/bib/bbab138
Autor:
Jin Liu, Feng Zhu, Xiuna Sun, Song Zhang, Huaicheng Sun, Xichen Lian, Kuerbannisha Amahong, Yunqing Qiu, Yan Lou
Publikováno v:
Briefings in Bioinformatics
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now, although a few drugs and vaccines have been proved for its treatment and prevention, little sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdf67a15d41e033547ec026a4aa193e
https://pubmed.ncbi.nlm.nih.gov/33675361
https://pubmed.ncbi.nlm.nih.gov/33675361
Autor:
Xichen Liang, Kseniia M. Karnaukh, Lei Zhao, Serena Seshadri, Austin J. DuBose, Sophia J. Bailey, Qixuan Cao, Marielle Cooper, Hao Xu, Michael Haggmark, Matthew E. Helgeson, Michael Gordon, Paolo Luzzatto-Fegiz, Javier Read de Alaniz, Yangying Zhu
Publikováno v:
ACS Central Science, Vol 10, Iss 3, Pp 684-694 (2024)
Externí odkaz:
https://doaj.org/article/b60451041bcf4e8dabe6299cdaefb33a