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Signature peptide selection workflow for biomarker quantification using LC–MS-based targeted proteomics

Autor: Xiazi I Qiu, Kenneth J Ruterbories, Qin C Ji, Gary J Jenkins

Publikováno v: Bioanalysis. 15:295-300

In contrast to quantification of biotherapeutics, endogenous protein biomarker and target quantification using LC–MS based targeted proteomics can require a much more stringent and time-consuming tryptic signature peptide selection for each specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f46c99ba09544003642a8a61205c46b
https://doi.org/10.4155/bio-2022-0241

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Comparison of three parallelism assessment methods of biomarker quantification by LC-MS/MS: a case study of the bioanalysis of creatinine in human urine samples

Autor: Xiazi I Qiu, John P Savaryn, Kenneth J Ruterbories, Qin C Ji, Gary Jenkins

Publikováno v: Bioanalysis. 14(5)

Background: Currently, no regulatory guidelines are available for parallelism assessment for LC-MS biomarker quantification. Spike recovery, standard addition and dilutional linearity are recommended with no mention of the implications of applying th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffc8115ca01b6afa3cd8e4f7f615476
https://pubmed.ncbi.nlm.nih.gov/35188423

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