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Akademický článek

LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers

Autor: Amriti R. Lulla, Said Akli, Cansu Karakas, Min Jin Ha, Natalie W. Fowlkes, Yoshitsugu Mitani, Tuyen Bui, Jing Wang, Xiayu Rao, Kelly K. Hunt, Laurent Meijer, Adel K. El-Naggar, Khandan Keyomarsi

Publikováno v: Oncogenesis, Vol 10, Iss 5, Pp 1-17 (2021)

Abstract Salivary gland cancers (SGCs) are rare yet aggressive malignancies with significant histological heterogeneity, which has made prediction of prognosis and development of targeted therapies challenging. In majority of patients, local recurren

Externí odkaz: https://doaj.org/article/67fdba0de22d4267a0520b6c3002e1fc

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Akademický článek

Non‐canonical cMet regulation by vimentin mediates Plk1 inhibitor–induced apoptosis

Autor: Ratnakar Singh, Shaohua Peng, Pavitra Viswanath, Vaishnavi Sambandam, Li Shen, Xiayu Rao, Bingliang Fang, Jing Wang, Faye M Johnson

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 5, Pp 1-20 (2019)

Abstract To address the need for improved systemic therapy for non–small‐cell lung cancer (NSCLC), we previously demonstrated that mesenchymal NSCLC was sensitive to polo‐like kinase (Plk1) inhibitors, but the mechanisms of resistance in epithe

Externí odkaz: https://doaj.org/article/4246619e4ece41939b17304846962bc4

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Akademický článek

Whole Exome Sequencing of Cell-Free DNA for Early Lung Cancer: A Pilot Study to Differentiate Benign From Malignant CT-Detected Pulmonary Lesions

Autor: Tina D. Tailor, Xiayu Rao, Michael J. Campa, Jing Wang, Simon G. Gregory, Edward F. Patz Jr.

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Introduction: Indeterminate pulmonary lesions (IPL) detected by CT pose a significant clinical challenge, frequently necessitating long-term surveillance or biopsy for diagnosis. In this pilot investigation, we performed whole exome sequencing (WES)

Externí odkaz: https://doaj.org/article/e870736bdd01495ea400074938602925

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Akademický článek

RNA-Seq Analysis of Differential Splice Junction Usage and Intron Retentions by DEXSeq.

Autor: Yafang Li, Xiayu Rao, William W Mattox, Christopher I Amos, Bin Liu

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0136653 (2015)

Alternative splicing is an important biological process in the generation of multiple functional transcripts from the same genomic sequences. Differential analysis of splice junctions (SJs) and intron retentions (IRs) is helpful in the detection of a

Externí odkaz: https://doaj.org/article/255f1651f99142b594926d7780439ae1

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Omics analyses of a somaticiTrp53supR245W/+/sup/ibreast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling

Autor: Xiaojie Yu, Yun Zhang, Shunbin Xiong, Joy M. McDaniel, Chang Sun, Gilda P. Chau, Jovanka Gencel-Augusto, Dhruv Chachad, Rhiannon L. Morrissey, Xiayu Rao, Jing Wang, Guillermina Lozano

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(45)

Alterations of the tumor suppressor TP53 , one of the most common events in cancer, alone are insufficient for tumor development but serve as drivers of transformation. We sought to identify cooperating events through genomic analyses of a somatic Tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de068d27b2b2e13972e13f6779580b9d
https://pubmed.ncbi.nlm.nih.gov/36322759

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Data from Comprehensive Genomic Profiling of Metastatic Squamous Cell Carcinoma of the Anal Canal

Autor: Cathy Eng, Kenna Shaw, Jing Wang, Ken Chen, Taebeom Kim, Karina Eterovic, Asif Rashid, Wai Chin Foo, Curtis Pickering, Xiayu Rao, Van Morris

Squamous cell carcinoma of the anal canal (SCCA) is a rare gastrointestinal malignancy with an increasing annual incidence globally. The majority of cases are linked to prior infection with the human papillomavirus (HPV). For patients with metastatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aac7728efbeb8a8670c6e02c2e2bd6e1
https://doi.org/10.1158/1541-7786.c.6539770.v1

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