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Akademický článek

204 ZEB2 acts as a crucial transcriptional regulator governing age- associated B cell formation and pathogenicity in systemic lupus erythematosus

Autor: Sheng Chen, Nan Shen, Yang Jiang, Huihua Ding, Dai Dai, Xiaxia Han, Shuangshuang Gu

Publikováno v: Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)

Externí odkaz: https://doaj.org/article/949cc28f0ddf41319714dd986099248b

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Akademický článek

LSO-001 Modulating T-bet-promoted energy metabolism in pathogenic age/autoimmune-associated B cells ameliorates lupus autoimmunity

Autor: Nan Shen, Dai Dai, Xiaxia Han

Publikováno v: Lupus Science and Medicine, Vol 10, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/f7f36c36268e4632839423f305115418

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Modulating T-bet-promoted energy metabolism in pathogenic age/autoimmune-associated B cells ameliorates lupus autoimmunity

Autor: Xiaxia, Han, Shuangshuang, Gu, Soon-Min, Hong, Yang, Jiang, Jinsong, Zhang, Chao, Yao, Zhihua, Yin, Zhizhong, Ye, Huihua, Ding, Sheng, Chen, Dai, Dai, Nan, Shen

Publikováno v: Arthritisrheumatology (Hoboken, N.J.).

Emerging evidences indicate that a distinct CD11cWe developed a T-bet-tdTomato reporter mouse strain to trace live T-betABCs exhibited a hypermetabolic state with enhanced glycolytic capacity. The increased glycolytic rate in ABCs was promoted by IFN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c48638ea754729ca6f4919fbc73e7a2b
https://pubmed.ncbi.nlm.nih.gov/36575806

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The transcription factor Zeb2 drives differentiation of age-associated B cells

Autor: Sheng Chen, Huihua Ding, Jie Qian, Shuangshuang Gu, Jinsong Zhang, Haibo Zhou, Qiang Guo, Carola G. Vinuesa, Xiaxia Han, Zhihua Ying, Bo Qu, Guojun Hou, Nan Shen, Zhizhong Ye, Chao Yao, Dai Dai

Age-associated B cells (ABCs) accumulate after infection, during aging, and in systemic autoimmunity, contributing to pathogenesis in the latter1. To date, their precise ontogeny and whether they represent a B cell subset distinct from the other majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::103b9683ce8e45bcb5cf84c04660e8a5
https://doi.org/10.1101/2021.07.24.453633

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Parathyroid Hormone Fragments: New Targets for the Diagnosis and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder

Autor: Yogendranath Purrunsing, Ningning Wang, Yangfan Ye, Ying Cui, Xiaxia Han, Huimin Chen

Publikováno v: BioMed Research International, Vol 2018 (2018)
BioMed Research International

As a common disorder, chronic kidney disease (CKD) poses a great threat to human health. Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a complication of CKD characterized by disturbances in the levels of calcium, phosphorus, parathyro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af81141c42ff4edbd10c30c74421fb12
https://doaj.org/article/ef7fb766a45245af8569a51ac1003c6f

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