Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Xiawei Dang"'
Autor:
Antonietta Franco, Jiajia Li, Daniel P Kelly, Ray E Hershberger, Ali J Marian, Renate M Lewis, Moshi Song, Xiawei Dang, Alina D Schmidt, Mary E Mathyer, John R Edwards, Cristina de Guzman Strong, Gerald W Dorn
Publikováno v:
eLife, Vol 12 (2023)
Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represe
Externí odkaz:
https://doaj.org/article/c8163fadb630467b8faefb631505c99f
Publikováno v:
Chemistry, Vol 4, Iss 3, Pp 655-668 (2022)
Piperine (1-piperoylpiperidine) is the major pungent component of black pepper (Piper nigrum) and exhibits a spectrum of pharmacological activities. The molecular bases for many of piperine’s biological effects are incompletely defined. We noted th
Externí odkaz:
https://doaj.org/article/bce443c447e74d4d8b7680de53887ef7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mitochondrial repair is essential to metabolic homeostasis. Outer mitochondrial membrane mitofusin (MFN) proteins orchestrate mitochondrial fusion that opposes mitochondrial degeneration caused by senescence. Depending upon physiological context, MFN
Externí odkaz:
https://doaj.org/article/619ed73adb3549c293905baa1bf2c395
Publikováno v:
Life, Vol 12, Iss 12, p 2110 (2022)
Phenotypic variations in Charcot-Marie-Tooth disease type 2A (CMT2A) result from the many mutations in the mitochondrial fusion protein, mitofusin 2 (MFN2). While the GTPase domain mutations of MFN2 lack the ability to hydrolyze GTP and complete mito
Externí odkaz:
https://doaj.org/article/27e58eb8005141a4b94788399de997d6
Autor:
Antonietta Franco, Xiawei Dang, Emily K Walton, Joshua N Ho, Barbara Zablocka, Cindy Ly, Timothy M Miller, Robert H Baloh, Michael E Shy, Andrew S Yoo, Gerald W Dorn II
Publikováno v:
eLife, Vol 9 (2020)
Charcot–Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2. Here, pharmacological activation of endogenous normal mitofusins overcame domi
Externí odkaz:
https://doaj.org/article/2983e0e917dc43b4836b3ed499e4fed0
Autor:
Gerald W. Dorn, Xiawei Dang
Publikováno v:
Cells, Vol 11, Iss 6, p 1049 (2022)
Mitochondrial dynamics encompass mitochondrial fusion, fission, and movement. Mitochondrial fission and fusion are seemingly ubiquitous, whereas mitochondrial movement is especially important for organelle transport through neuronal axons. Here, we r
Externí odkaz:
https://doaj.org/article/070df9c327694155951840ea49354551
Autor:
Xiawei Dang, Emily K. Walton, Barbara Zablocka, Robert H. Baloh, Michael E. Shy, Gerald W. Dorn
Publikováno v:
Cells, Vol 11, Iss 6, p 1053 (2022)
Mitochondrial fusion is essential to mitochondrial fitness and cellular health. Neurons of patients with genetic neurodegenerative diseases often exhibit mitochondrial fragmentation, reflecting an imbalance in mitochondrial fusion and fission (mitoch
Externí odkaz:
https://doaj.org/article/6901f73ebdb242989b6f1a86420102d2
Autor:
Franco, Antonietta, Jiajia Li, Kelly, Daniel P., Hershberger, Ray E., Marian, Ali J., Lewis, Renate M., Moshi Song, Xiawei Dang, Schmidt, Alina D., Mathyer, Mary E., Edwards, John R., de Guzman Strong, Cristina, Dorn, Gerald W.
Publikováno v:
eLife; 11/1/2023, p1-28, 28p
Autor:
Antonietta Franco, Jiajia Li, Daniel P. Kelly, Ray E. Hershberger, Ali J. Marian, Renate M. Lewis, Moshi Song, Xiawei Dang, Alina D. Schmidt, Mary E. Mathyer, Cristina de Guzman Strong, Gerald W. Dorn
Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is ~20x over-represented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e12c0e9e7e12b7bfd685e659c6f90a
https://doi.org/10.1101/2022.11.22.517462
https://doi.org/10.1101/2022.11.22.517462
Autor:
Xiawei Dang, Antonietta Franco, Daniel Walters, Bernstein Peter Robert, Sidney B. Williams, Lijun Fu, Sriram Devanathan, Gerald W. Dorn
Publikováno v:
J Med Chem
Mitochondrial fragmentation from defective fusion or unopposed fission contributes to many neurodegenerative diseases. Small molecule mitofusin activators reverse mitochondrial fragmentation in vitro, promising a novel therapeutic approach. The first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be13bb2bf8f2df50171ea1019aa1b46
https://doi.org/10.1021/acs.jmedchem.1c00163
https://doi.org/10.1021/acs.jmedchem.1c00163