Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Xiaozhe Ding"'
Autor:
Xinhong Chen, Damien A. Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F. Shay, Erin E. Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar, Cynthia M. Arokiaraj, Viktor M. Plattner, Lillian J. Campos, John K. Mich, Deja Monet, Victoria Ngo, Xiaozhe Ding, Victoria Omstead, Natalie Weed, Yeme Bishaw, Bryan B. Gore, Ed S. Lein, Athena Akrami, Cory Miller, Boaz P. Levi, Annika Keller, Jonathan T. Ting, Andrew S. Fox, Cagla Eroglu, Viviana Gradinaru
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing neurological diseases. We have evolved adeno-associated virus (AAV9) capsids into vectors that trans
Externí odkaz:
https://doaj.org/article/7b4783a47cea47ffabf5e460813881df
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 343-354 (2022)
Adeno-associated virus serotype 9 (AAV9) is a promising gene therapy vector for treating neurodegenerative diseases due to its ability to penetrate the blood-brain barrier. PHP.eB was engineered from AAV9 by insertion of a 7-amino acid peptide and po
Externí odkaz:
https://doaj.org/article/df4fd9859c1b4dfeae3dfa8b780af72e
Autor:
Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Adeno-associated viruses (AAVs) can be targeted in a tissue-specific manner, but their tissue accumulation cannot be assessed in a non-invasive manner. Here the authors conjugate a multivalent chelator labelled with Cu-64 to the surface of AAVs and i
Externí odkaz:
https://doaj.org/article/3bffb0cc262e4293b560a67f7e3c6fd9
Autor:
Songming Peng, Jesse M. Zaretsky, Alphonsus H.C. Ng, William Chour, Michael T. Bethune, Jongchan Choi, Alice Hsu, Elizabeth Holman, Xiaozhe Ding, Katherine Guo, Jungwoo Kim, Alexander M. Xu, John E. Heath, Won Jun Noh, Jing Zhou, Yapeng Su, Yue Lu, Jami McLaughlin, Donghui Cheng, Owen N. Witte, David Baltimore, Antoni Ribas, James R. Heath
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2728-2738.e7 (2019)
Summary: Neoantigen-specific T cells are increasingly viewed as important immunotherapy effectors, but physically isolating these rare cell populations is challenging. Here, we describe a sensitive method for the enumeration and isolation of neoantig
Externí odkaz:
https://doaj.org/article/43a6df712a824f30a578af81377be174
Autor:
Timothy F. Shay, Erin E. Sullivan, Xiaozhe Ding, Xinhong Chen, Sripriya Ravindra Kumar, David Goertsen, David Brown, Anaya Crosby, Jost Vielmetter, Máté Borsos, Damien A. Wolfe, Annie W. Lam, Viviana Gradinaru
Publikováno v:
Science Advances. 9
The blood-brain barrier (BBB) presents a major challenge for delivering large molecules to study and treat the central nervous system. This is due in part to the scarcity of targets known to mediate BBB crossing. To identify novel targets, we leverag
Deep learning-based methods for protein structure prediction have achieved unprecedented accuracy. However, the power of these tools to guide the engineering of protein-based therapeutics remains limited due to a gap between the ability to predict th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eacadc83d91bda5ed6bc34c0d712c18
https://doi.org/10.1101/2023.01.11.523680
https://doi.org/10.1101/2023.01.11.523680
Autor:
Timothy F. Shay, Erin E. Sullivan, Xiaozhe Ding, Xinhong Chen, Sripriya Ravindra Kumar, David Goertsen, David Brown, Jost Vielmetter, Máté Borsos, Annie W. Lam, Viviana Gradinaru
The blood-brain barrier (BBB) presents a major challenge to delivering large molecules to study and treat the central nervous system (CNS). This is due in part to the scarcity of effective targets for BBB crossing, the identification of which is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af2d7463099cdc500b375c82200caad8
https://doi.org/10.1101/2023.01.12.523632
https://doi.org/10.1101/2023.01.12.523632
Autor:
Amy Henrickson, Gary E. Gorbet, Alexey Savelyev, Minji Kim, Sarah K. Schultz, Xiaozhe Ding, Jason Hargreaves, Viviana Gradinaru, Ute Kothe, Borries Demeler
Multi-wavelength analytical ultracentrifugation (MW-AUC) is a recent development made possible by new analytical ultracentrifuge optical systems. MW-AUC is suitable for a wide range of applications and biopolymer systems and is poised to become an es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23024054ba929958268dc92efac648c
https://doi.org/10.21203/rs.3.rs-1184379/v1
https://doi.org/10.21203/rs.3.rs-1184379/v1
Autor:
Poorva Jain, Eduardo A. Silva, Spencer K. Tumbale, Michelle L. James, Ryan D. Leib, Katherine W. Ferrara, Mo Baikoghli, Jai Woong Seo, Tatyana Dobreva, Michael Chavez, Bo Wu, David J. Segal, Nick Goeden, R. Holland Cheng, Lisa M. Mahakian, Kratika Singhal, Nicholas C. Flytzanis, Shahin Shams, Xiaozhe Ding, Elizabeth S. Ingham, Sadaf Aghevlian, Viviana Gradinaru
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Adeno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulated within 25-nm protein capsids. Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been shown to enhance brain delivery in rodents via the LY