Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Xiaoyun Qian"'
Publikováno v:
Engineered Regeneration, Vol 5, Iss 2, Pp 247-254 (2024)
Elevated levels of high mobility group protein B1 (HMGB1) play a significant role in the pathogenesis of many diseases, but is particularly important for the formation of malignant tumors. Nonetheless, the function of HMGB1 and the underlying mechani
Externí odkaz:
https://doaj.org/article/94b462d9aefd43f09f8bdc366e9b5531
Autor:
Jieyu Qi, Fangzhi Tan, Liyan Zhang, Ling Lu, Hongyang Wang, Wenyan Li, Wenwen Liu, Xiaolong Fu, Zuhong He, Xiaoqiong Ding, Shan Sun, Qiaojun Fang, Yaodong Dong, Xuewei Zhu, Busheng Tong, Xianbao Cao, Min Guo, Xinmiao Fan, Qin Wang, Lu Ma, Tianhong Zhang, Yafeng Yu, Yongxin Li, Jiangang Fan, Yong Cui, Peina Wu, Hongzheng Zhang, Jie Tang, Weiwei Guo, Dingjun Zha, Fanglei Ye, Shuangba He, Wei Cao, Jianming Yang, Xiaoyun Qian, Yu Zhao, Jingwu Sun, Xiaowei Chen, Yu Sun, Ming Xia, Qiuju Wang, Huijun Yuan, Yong Feng, Weijia Kong, Shiming Yang, Haibo Wang, Maoli Duan, Xia Gao, Huawei Li, Lei Xu, Renjie Chai
Publikováno v:
Interdisciplinary Medicine, Vol 2, Iss 2, Pp n/a-n/a (2024)
Abstract Hereditary deafness is a common neurosensory disorder, and 148 non‐syndromic deafness genes have been identified to date. Gene therapy has been used to treat a variety of genetic diseases, but no gene therapy drug for hereditary deafness h
Externí odkaz:
https://doaj.org/article/ea0f2a4230db4684af2f3df943975776
Autor:
Jieyu Qi, Fangzhi Tan, Liyan Zhang, Ling Lu, Shanzhong Zhang, Yabo Zhai, Yicheng Lu, Xiaoyun Qian, WenXiu Dong, Yinyi Zhou, Ziyu Zhang, Xuehan Yang, Lulu Jiang, Chaorong Yu, Jiancheng Liu, Tian Chen, Lianqiu Wu, Chang Tan, Sijie Sun, Huaien Song, Yilai Shu, Lei Xu, Xia Gao, Huawei Li, Renjie Chai
Publikováno v:
Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract Mutations in OTOFERLIN (OTOF) lead to the autosomal recessive deafness 9 (DFNB9). The efficacy of adeno‐associated virus (AAV)‐mediated OTOF gene replacement therapy is extensively validated in Otof‐deficient mice. However, the clinica
Externí odkaz:
https://doaj.org/article/13ae727fa26b405d86d815a31da8c0fe
Autor:
Guang‐Jie Zhu, Yuhang Huang, Linqing Zhang, Keji Yan, Cui Qiu, Yihan He, Qing Liu, Chengwen Zhu, Matías Morín, Miguel Ángel Moreno‐Pelayo, Min‐Sheng Zhu, Xin Cao, Han Zhou, Xiaoyun Qian, Zhigang Xu, Jie Chen, Xia Gao, Guoqiang Wan
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Cingulin (CGN) is a cytoskeleton‐associated protein localized at the apical junctions of epithelial cells. CGN interacts with major cytoskeletal filaments and regulates RhoA activity. However, physiological roles of CGN in development and
Externí odkaz:
https://doaj.org/article/8e775ad618694efebba7ec761a5f62d4
Autor:
Ao Li, Haoliang Du, Junyan Gao, Yuqin Xu, Ning Zhao, Song Gao, Yuxuan Xing, Xiaoyun Qian, Xia Gao, Ye Yang
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
ObjectiveTo describe the characteristics of large vestibular aqueduct syndrome (LVAS) in wideband acoustic immittance (WAI) and to explore whether inner ear deformity has an impact on WAI results.MethodsSubjects with typical LVAS (LVAS group) and con
Externí odkaz:
https://doaj.org/article/74aa0040b37e4aab9c7961395b9c7c40
Autor:
ZhengRong Xu, LingNa Guo, XiaoYun Qian, ChenJie Yu, ShengJu Li, ChengWen Zhu, XiaoFeng Ma, Hui Li, GuangJie Zhu, Han Zhou, WenXuan Dai, Qian Li, Xia Gao
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Orthosteric binding sites of olfactory receptors have been well understood for ligand-receptor interactions. However, a lack of explanation for subtle differences in ligand profile of olfactory receptors even with similar orthosteric binding
Externí odkaz:
https://doaj.org/article/a41d346d07e34123a68a9b7a1e2c6f86
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
ObjectiveThis study aimed to investigate the differences in intra-regional brain activity and inter-regional functional connectivity between patients with recent-onset tinnitus (ROT) and persistent tinnitus (PT) using resting-state functional magneti
Externí odkaz:
https://doaj.org/article/e2d0794b210342a4afd4441922de9cfe
Autor:
Xiaoqiong Ding, Yangnan Hu, Hong Cheng, Xiaoli Zhang, Ling Lu, Song Gao, Cheng Cheng, Lifen Wang, Xiaoyun Qian, Chen Zhang, Renjie Chai, Xia Gao, Zhichun Huang
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The ideal treatment for sensory hearing loss is to regenerate inner ear hair cells (HCs) through stem cell therapy, thereby restoring the function and structure of the cochlea. Previous studies have found that Lgr5+ supporting cells (SCs) in the inne
Externí odkaz:
https://doaj.org/article/1c56e81057a1424bb0a591ebd8b052af
Autor:
Yuan Zhang, Shasha Zhang, Han Zhou, Xiangyu Ma, Leilei Wu, Mengyao Tian, Siyu Li, Xiaoyun Qian, Xia Gao, Renjie Chai
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010232 (2022)
Dync1li1, a subunit of cytoplasmic dynein 1, is reported to play important roles in intracellular retrograde transport in many tissues. However, the roles of Dync1li1 in the mammalian cochlea remain uninvestigated. Here we first studied the expressio
Externí odkaz:
https://doaj.org/article/3c77a8b5d9f84d63913066f7336769f1
Publikováno v:
International Journal of Genomics, Vol 2022 (2022)
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with a high mortality rate. The tumor microenvironment (TME) is composed of numerous noncancerous cells that contribute to tumorigenesis and prediction of therapeutic effects. I
Externí odkaz:
https://doaj.org/article/800e03b4bc864bd6b97b15af43769efd