Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Xiaoyun Meng"'
Autor:
Xiaoyun Meng, Lanjun Zhang, Hong Wei, Furong Li, Lihua Hu, Haiyun Ma, Qian Liu, Xiaoyu Li, Zhongchuan Liu
Publikováno v:
BioTechniques, Vol 69, Iss 1, Pp 70-76 (2020)
Refolding of human interleukin 17A (IL-17A) has been reported; however, the key refolding protocol was not robust enough to deliver consistent results and to be easily scaled up for crystallization. Here we report an optimized refolding method for IL
Externí odkaz:
https://doaj.org/article/aedfd84ddcf74489aa1ff529c1caad13
Publikováno v:
Parkinson's Disease, Vol 2010 (2010)
α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in neurons and are implicated in the causative pathogenesis of Parkinson's disease and other synucleinopathies. Currently, there is no approved therape
Externí odkaz:
https://doaj.org/article/d6a4ffc2de6d4a78a3343abcc5fee0c7
Autor:
Qiuxia Chen, Chuan Liu, Wei Wang, Xiaoyun Meng, Xuemin Cheng, Xianyang Li, Longying Cai, Linfu Luo, Xu He, Huan Qu, Jing Luo, Hong Wei, Sen Gao, Guansai Liu, Jinqiao Wan, David I. Israel, Jin Li, Dengfeng Dou
Publikováno v:
ACS Chemical Biology. 18:25-33
The proteolysis targeting chimera (PROTAC) strategy results in the down-regulation of unwanted protein(s) for disease treatment. In the PROTAC process, a heterobifunctional degrader forms a ternary complex with a target protein of interest (POI) and
Autor:
Paul G. Richardson, Xiaoyun Meng, Karen A. Maegley, A.E. Stewart, Pei-Pei Kung, Jose L Montano, Ya-Li Deng, Jinqiao Wan, Michael R. Gehring, Jordan L. Meier, Brigitte S Naughton, Stephan Grant, Dou Dengfeng, Chakrapani Subramanyam, Anthony R. Harris, Samantha Elizabeth Greasley, Barry A. Morgan, Wen Yan, Xuemin Cheng, Prakash B. Palde, William K Sonnenburg, Junli Feng, Chen Qiuxia, Thomas A Paul, Gary M. Gallego, Sylvie K. Sakata, Sergei Timofeevski, Patrick Bingham, Benjamin J. Burke, Alex Shaginian
Publikováno v:
ACS Med Chem Lett
[Image: see text] Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand thei
Publikováno v:
Parkinson's Disease
Parkinson's Disease, Vol 2010 (2010)
Parkinson's Disease, Vol 2010 (2010)
α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in neurons and are implicated in the causative pathogenesis of Parkinson's disease and other synucleinopathies. Currently, there is no approved therape
Publikováno v:
Biochemistry. 48:8206-8224
The molecular mechanism underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation was thoroughly examined by various biochemical and biophysical approaches. The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and
Publikováno v:
Bioelectrochemistry and Bioenergetics. 48:227-231
The electron transfer process of biological important species, superoxide dismutase (SOD), was studied using cyclic voltammetric method at different conditions. The rate of electron transfer process of SOD at conventional bare gold electrode was very
Publikováno v:
Journal of Optics. 17:125008
We propose a novel hybrid plasmonic waveguide with metal-semiconductor ribs. We investigated the modal properties of the proposed structure and the threshold property for plasmonic nanolaser applications by using the finite element method. The result
Autor:
Qingnian Zhang, Xiaoyun Meng
Publikováno v:
SPIE Proceedings.
Land use is an important field in the global environment change. This paper, taking Luocun town of NanHai District of Foshan city as an example, with the help of GIS techno logy, mathematics model and landscape-ecology theory, analyses the landscape