Zobrazeno 1 - 10
of 365
pro vyhledávání: '"Xiaoyun, Lu"'
Autor:
Yalei Wen, Hui Wang, Xiao Yang, Yingjie Zhu, Mei Li, Xiuqing Ma, Lei Huang, Rui Wan, Caishi Zhang, Shengrong Li, Hongling Jia, Qin Guo, Xiaoyun Lu, Zhengqiu Li, Xiangchun Shen, Qiushi Zhang, Lu Si, Chengqian Yin, Tongzheng Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Activating mutations in NRAS account for 15–20% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator of oncogenic NRAS mutations, specifica
Externí odkaz:
https://doaj.org/article/83e26542cf344856a8abf2d239e81390
Autor:
Hong Wang, Huizi Sun, Jie Huang, Zhenhua Zhang, Guodi Cai, Chaofan Wang, Kai Xiao, Xiaofeng Xiong, Jian Zhang, Peiqing Liu, Xiaoyun Lu, Weineng Feng, Junjian Wang
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2043-2059 (2024)
Abstract Small-cell lung cancer (SCLC) is the most aggressive and lethal type of lung cancer, characterized by limited treatment options, early and frequent metastasis. However, the determinants of metastasis in SCLC are poorly defined. Here, we show
Externí odkaz:
https://doaj.org/article/73f205a84a4949039ad407236f64b767
Publikováno v:
Journal of Functional Foods, Vol 121, Iss , Pp 106417- (2024)
Overnutrition triggers obesity and metabolic dysregulation, causing metaflammation. D-allulose, exhibits anti-obesity and hypoglycemic benefits. However, its involvement in metaflammation remains incompletely understood. In this study, high-fat diet-
Externí odkaz:
https://doaj.org/article/aa273a8e80c34ef5ad49e8c91b04164e
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-18 (2024)
Abstract Background Identifying new targets in triple negative breast cancer (TNBC) remains critical. REG3A (regenerating islet-derived protein 3 A), a calcium-dependent lectin protein, was thoroughly investigated for its expression and functions in
Externí odkaz:
https://doaj.org/article/c8a7b5c9ed1b40e1af937be3c75b0157
Autor:
Xiaoyun Lu, Jie Bai, Zunzhe Tian, Congyu Li, Nida Ahmed, Xiaonan Liu, Jian Cheng, Lina Lu, Jing Cai, Huifeng Jiang, Wen Wang
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 1, Pp 11-18 (2024)
Monoterpenoids are typically present in the secretory tissues of higher plants, and their biosynthesis is catalyzed by the action of monoterpene synthases (MTSs). However, the knowledge about these enzymes is restricted in a few plant species. MTSs a
Externí odkaz:
https://doaj.org/article/0d2ce794a9094b4080316a37ee519906
Autor:
Shuang Xiang, Xiaoyun Lu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 517-532 (2024)
Neurotrophic receptor kinase (NTRK) fusions are actionable oncogenic drivers of multiple pediatric and adult solid tumors, and tropomyosin receptor kinase (TRK) has been considered as an attractive therapeutic target for “pan-cancer” harboring th
Externí odkaz:
https://doaj.org/article/fb1aa15530ab401bbd921ce0f856db27
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109391- (2024)
Summary: The biosafety of terahertz (THz) waves has emerged as a new area of concern with the gradual application of terahertz radiation. Even though many studies have been conducted to investigate the influence of THz radiation on living organisms,
Externí odkaz:
https://doaj.org/article/147408a10a1b44df8415d792adab5089
Autor:
Li Shen, Ting Fu, Luguang Huang, Huiying Sun, Yu Wang, Lili Sun, Xiaoyun Lu, Jing Zhang, Zhaoxu Yang, Chunping Ni
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-8 (2023)
Abstract Background Catheter-associated urinary tract infection (CAUTI) ranks second among nosocomial infections in elderly patients after lung infections. Improper treatment can lead to death. This study analysed the risk factors, pathogen distribut
Externí odkaz:
https://doaj.org/article/e85d32c8bd974e04a76ff6bab3f1180d
Publikováno v:
Pain and Therapy, Vol 12, Iss 5, Pp 1195-1208 (2023)
Abstract Introduction Lead toxicity has been a major public health problem worldwide, yet no study has investigated the association between lead exposure and chronic pain. Methods We used data from three cycles of National Health and Nutrition Examin
Externí odkaz:
https://doaj.org/article/228ddab04484473fb23e1713ed3f299d
Autor:
Yongjin Wang, Yang Zhou, Chaowei Shi, Jiacong Liu, Guohua Lv, Huisi Huang, Shengrong Li, Liping Duan, Xinyi Zheng, Yue Liu, Haibo Zhou, Yonghua Wang, Zhengqiu Li, Ke Ding, Pinghua Sun, Yun Huang, Xiaoyun Lu, Zhi-Min Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Antimicrobial toxins are secreted by bacteria to kill rival species. Here the authors report the mechanism of inhibition of EsaD, a toxin secreted by some S. aureus strains to kill competitors that lack the antitoxin EsaG, showing marked mechanistic
Externí odkaz:
https://doaj.org/article/39d230a9e5b34ce1a16578c05946a891