Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Xiaoying Koh"'
Autor:
Zhewei Shen, Anna Halberg, Jia Yi Fong, Jingyu Guo, Gavin Song, Brent Louie, Gregory R. Luedtke, Viwat Visuthikraisee, Andrew A. Protter, Xiaoying Koh, Taegon Baik, Pek Yee Lum
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract COVID-19, first reported in late 2019, is an ongoing pandemic that has been causing devastation across the globe. Although there are multiple vaccines that can prevent severe symptoms, effective COVID-19 therapeutics are still of importance.
Externí odkaz:
https://doaj.org/article/81404399b2b949d4b11b40029d9e9453
Autor:
Yang Cao, Xiaoying Koh, Libo Dong, Xiangjun Du, Aiping Wu, Xilai Ding, Hongyu Deng, Yuelong Shu, Jianzhu Chen, Taijiao Jiang
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18664 (2011)
A critical step for avian influenza viruses to infect human hosts and cause epidemics or pandemics is acquisition of the ability of the viral hemagglutinin (HA) to bind to human receptors. However, current global influenza surveillance does not monit
Externí odkaz:
https://doaj.org/article/63804138779d424589d11b0621f9e0ea
Autor:
Karthik Viswanathan, Xiaoying Koh, Aarthi Chandrasekaran, Claudia Pappas, Rahul Raman, Aravind Srinivasan, Zachary Shriver, Terrence M Tumpey, Ram Sasisekharan
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13768 (2010)
The H2N2 subtype of influenza A virus was responsible for the Asian pandemic of 1957-58. However, unlike other subtypes that have caused pandemics such as H1N1 and H3N2, which continue to circulate among humans, H2N2 stopped circulating in the human
Externí odkaz:
https://doaj.org/article/7289c708cad84079acda45d64877ec00
Autor:
Subramanyam Vankadara, Monique Danielle Dawson, Jia Yi Fong, Qin Yao Oh, Qi An Ang, Boping Liu, Hong Yun Chang, Judice Koh, Xiaoying Koh, Qian Wen Tan, Joma Joy, Cheng San Brian Chia
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1345-1350
The SARS-CoV-2 pandemic is currently causing an unprecedented global health emergency since its emergence in December 2019. In December 2021, the FDA granted emergency use authorization to nirmatrelvir, a SARS-CoV-2 main protease inhibitor, for treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc58a72649da2362b65c76b155f20e55
https://doi.org/10.1021/acsmedchemlett.2c00260
https://doi.org/10.1021/acsmedchemlett.2c00260
Autor:
Zhewei Shen, Anna Halberg, Jia Yi Fong, Jingyu Guo, Gavin Song, Brent Louie, Gregory R. Luedtke, Viwat Visuthikraisee, Andy Protter, Xiaoying Koh, Taegon Baik, Pek Yee Lum
COVID-19 is an ongoing pandemic that has been causing devastation across the globe for over 2 years. Although there are multiple vaccines that can prevent severe symptoms, effective COVID-19 therapeutics are still of importance. Using our proprietary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::062aef351d2b12328e87b6443a94cce3
https://doi.org/10.1101/2022.04.18.488682
https://doi.org/10.1101/2022.04.18.488682
Autor:
Yee Hwa Wong, CongBao Kang, Xiaoying Koh-Stenta, Alex Matter, Wenhe Zhong, Hui Qi Ng, Klement Foo, Megan E. McBee, Ann Koay, Anders Poulsen, Julien Lescar, Jeffrey Hill, Abbas El Sahili, Qianhui Nah, Yan Li, Yok Hian Chionh, Anna Ngo, Meng Ling Choong, Peter C. Dedon
Publikováno v:
ACS Infectious Diseases. 5:326-335
Bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. One such target is the tRNA-(N1G37) methyltransferase (TrmD), which is conserved an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba136b2d4dbc1e07c0350f39a81a8c5
https://doi.org/10.1021/acsinfecdis.8b00275
https://doi.org/10.1021/acsinfecdis.8b00275
Autor:
Jeffrey Hill, Joma Joy, Grace Lin, Nurul Dinie, Justina Fulwood, Sin Yin Chew, Xiaoying Koh-Stenta, Sugunavathi Sepramaniam, Xin Hui Chew, Rong Li, Melgious Jin Yan Ang, May Ann Lee, Alex Matter, Weixuan Yu, Zhiyuan Ke, Anna Ngo, Hwa Hwa Chung, Susmitha Vuddagiri, Kanda Sangthongpitag, Klement Foo, Vithya Manoharan, C. S. Brian Chia, Sravanthy Manesh, Esther H. Q. Ong, Nithya Baburajendran, Chuhui Huang, Zekui Perlyn Kwek, John Liang Kuan Wee, Yun Shan Chew, Priya Retna, Thomas H. Keller, Anders Poulsen, Si Si Liew, Choon Bing Low, Vishal Pendharkar
Publikováno v:
ACS Med Chem Lett
[Image: see text] SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a957218bb54c41c184fbdaf7cb115a0
https://europepmc.org/articles/PMC6580565/
https://europepmc.org/articles/PMC6580565/
Autor:
Qianhui Nah, Wenhe Zhong, Yan Li, Jeffrey Hill, Hui Qi Ng, Siau Hoi Lim, Ann Zhufang Koay, Peter C. Dedon, CongBao Kang, Julien Lescar, Andreas Larsson, Xiaoying Koh-Stenta
Publikováno v:
Josephina Lee
Bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) is an important antibacterial target due to its essential role in translation. TrmD has two domains connected with a flexible linker. The N-terminal domain (NTD) of TrmD contains the S-adenosyl-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513fa150696eb9febd91062bddc23789
https://hdl.handle.net/10356/150609
https://hdl.handle.net/10356/150609
Autor:
Yan, Li, Wenhe, Zhong, Ann Zhufang, Koay, Hui Qi, Ng, Xiaoying, Koh-Stenta, Qianhui, Nah, Siau Hoi, Lim, Andreas, Larsson, Julien, Lescar, Jeffrey, Hill, Peter C, Dedon, CongBao, Kang
Publikováno v:
Biomolecular NMR assignments. 13(1)
Bacterial tRNA (guanine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4a98a7705a9a84ad4ec57c8874c037b
https://pubmed.ncbi.nlm.nih.gov/30298375
https://pubmed.ncbi.nlm.nih.gov/30298375
Autor:
Henry Yang, Xiaoying Koh-Stenta, Joma Joy, Tim Chan, Alvin W. Hung, J. Sivaraman, Feng Li, Anders Poulsen, Yaw Sing Tan, Jeffrey Hill, Chandra S. Verma, Bee Hui Liu, Chan-Shuo Wu, Hong Kee Tan, C. S. Brian Chia, Chacko Jobichen, Jia Li, Jing Ping Tang, Li Chai, Daniel G. Tenen, Theodora X. Y. Chung
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Sal-like 4 (SALL4) is a nuclear factor central to the maintenance of stem cell pluripotency and is a key component in hepatocellular carcinoma, a malignancy with no effective treatment. In cancer cells, SALL4 associates with nucleosome remodeling dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf4aef2126c6a2c15771c4460a0715b
https://doi.org/10.1073/pnas.1801253115
https://doi.org/10.1073/pnas.1801253115