Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Xiaoyan M Zhang"'
Autor:
Nathan T Morrell, Philipp Leucht, Ludan Zhao, Jae-Beom Kim, Derk ten Berge, Karthik Ponnusamy, A Lyonel Carre, Henryk Dudek, Marie Zachlederova, Michael McElhaney, Shirley Brunton, Janet Gunzner, Marinella Callow, Paul Polakis, Mike Costa, Xiaoyan M Zhang, Jill A Helms, Roel Nusse
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2930 (2008)
Wnt signals exercise strong cell-biological and regenerative effects of considerable therapeutic value. There are, however, no specific Wnt agonists and no method for in vivo delivery of purified Wnt proteins. Wnts contain lipid adducts that are requ
Externí odkaz:
https://doaj.org/article/9d6786461d08499396af9c7a5f3c0bb3
Autor:
Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo, Brad St. Croix
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative
Externí odkaz:
https://doaj.org/article/de07b7cafa8043a9b3901cf413b35629
Autor:
Jeffrey Ecsedy, Xiaoyan M. Zhang, Mark Manfredi, Prabitha Natarajan, Sakeena Syed, Jeremy Tchaicha, Meghan Walsh, Silvia Coma, Jill Cavanaugh, Alfredo C. Castro, Karen McGovern
Supplementary Table from Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a11276840ac47ab69018568d15800d
https://doi.org/10.1158/1535-7163.22523289.v1
https://doi.org/10.1158/1535-7163.22523289.v1
Autor:
Jeffrey Ecsedy, Xiaoyan M. Zhang, Mark Manfredi, Prabitha Natarajan, Sakeena Syed, Jeremy Tchaicha, Meghan Walsh, Silvia Coma, Jill Cavanaugh, Alfredo C. Castro, Karen McGovern
Supplementary Figure from Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050525c3bfe144ac014dd2f1d4357a1f
https://doi.org/10.1158/1535-7163.22523295.v1
https://doi.org/10.1158/1535-7163.22523295.v1
Autor:
John Blazeck, Christos S. Karamitros, Kyle Ford, Catrina Somody, Ahlam Qerqez, Kyle Murray, Nathaniel T. Burkholder, Nicholas Marshall, Anirudh Sivakumar, Wei-Cheng Lu, Bing Tan, Candice Lamb, Yuri Tanno, Menna Y. Siddiqui, Norah Ashoura, Silvia Coma, Xiaoyan M. Zhang, Karen McGovern, Yoichi Kumada, Yan Jessie Zhang, Mark Manfredi, Kenneth A. Johnson, Sheena D’Arcy, Everett Stone, George Georgiou
Publikováno v:
Nat Catal
The Trp metabolite kynurenine (KYN) accumulates in numerous solid tumours and mediates potent immunosuppression. Bacterial kynureninases (KYNases), which preferentially degrade kynurenine, can relieve immunosuppression in multiple cancer models, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0ac6472e6fbfd35f3de3a946823b38
https://europepmc.org/articles/PMC9717613/
https://europepmc.org/articles/PMC9717613/
Autor:
Karen McGovern, Alfredo C. Castro, Jill Cavanaugh, Silvia Coma, Meghan Walsh, Jeremy Tchaicha, Sakeena Syed, Prabitha Natarajan, Mark Manfredi, Xiaoyan M. Zhang, Jeffrey Ecsedy
Publikováno v:
Molecular cancer therapeutics. 21(8)
Aryl hydrocarbon receptor (AHR) is a transcription factor that regulates the activity of multiple innate and adaptive immune cells subsequent to binding to numerous endogenous and exogenous ligands. For example, AHR is activated by the metabolite kyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5472282317b508d39d9d8194eaf7a68
https://pubmed.ncbi.nlm.nih.gov/35666806
https://pubmed.ncbi.nlm.nih.gov/35666806
Autor:
Xiaoyan M. Zhang, Enrique Zudaire, Brad St. Croix, Karen Morris, Jennifer Hwang, Dean Welsch, Guojun Yu, James M. Dunleavey, Yang Feng, Steven Seaman, Diana C. Haines, Decrescenzo Gary A, Saurabh Saha, Kuo Sheng Hsu, Zhongyu Zhu, Mary Beth Hilton, Christopher S. Szot, Dimiter S. Dimitrov, Deborah A. Swing, Yanping Wang, Amit Chaudhary, Holly Morris
Publikováno v:
Journal of Clinical Investigation. 128:2927-2943
Although nonmalignant stromal cells facilitate tumor growth and can occupy up to 90% of a solid tumor mass, better strategies to exploit these cells for improved cancer therapy are needed. Here, we describe a potent MMAE-linked antibody-drug conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::016363636dbdebda9179410617e48d5f
https://doi.org/10.1172/jci120481
https://doi.org/10.1172/jci120481
Autor:
Kyle Ford, George Georgiou, Nicholas M. Marshall, Mena S. Yamany, George Fromm, Mark G. Manfredi, Karen McGovern, Enrique Sentandreu, Taylor H. Schreiber, Moses Donkor, Lauren I.R. Ehrlich, Ahlam Qerqez, Bing Tan, Stefano Tiziani, Candice Lamb, Xiaoyan M. Zhang, Yuri Tanno, Silvia Coma, Wei Cheng Lu, Christos S. Karamitros, Kendra Garrison, Todd A. Triplett, Everett Stone, Yoichi Kumada, John Blazeck, Joseph D. Dekker
Publikováno v:
Nature biotechnology
Increased tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of interferon (IFN)-γ-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predominantly liver-restrict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7168d6ee38b6d609b04dcfb556f476
https://pubmed.ncbi.nlm.nih.gov/30010674
https://pubmed.ncbi.nlm.nih.gov/30010674
Autor:
Sylvia Degrado, Kimberly D. Klarmann, Dimiter S. Dimitrov, Julia Scheiermann, Brad St. Croix, Zhongyu Zhu, Dmitry Borkin, Yang Feng, Steven Seaman, Mi Young Yang, Enrique Zudaire, Holly Morris, Yanping Wang, Nareshkumar F. Jain, Karen Morris, Jinyu Li, Mary Beth Hilton, Sean W. Smith, Jonathan R. Keller, Lino Tessarollo, Saurabh Saha, Christopher S. Szot, Amit Chaudhary, Deborah A. Swing, Xiaoyan M. Zhang, Decrescenzo Gary A, Dean Welsch
Publikováno v:
Cancer cell. 31(4)
Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal warheads. Here, we demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257e54fd4eb07b60c386f5f0fcd573a3
https://pubmed.ncbi.nlm.nih.gov/28399405
https://pubmed.ncbi.nlm.nih.gov/28399405
Autor:
Barry A. Siegel, Xiaoyan M. Zhang, James J Conklin, Halle H. Zhang, Chantal Petit, Patrick McLeroth, Jeffrey Gelb, John Spaltro, Michael A. Mont, Abass Alavi, Steve Y. Cho, Saurabh Saha, T. Marc Barnett, Chetan Bettegowda, Michael G. Stabin, Martin G. Pomper, Richard D. Berkowitz
Publikováno v:
Nuclear medicine and biology. 43(5)
Introduction Fialuridine (FIAU) is a nucleoside analog that is a substrate for bacterial thymidine kinase (TK). Once phosphorylated by TK, [ 124 I]FIAU becomes trapped within bacteria and can be detected with positron emission tomography/computed tom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f399cf097e28e7e2239497c31d336d
https://pubmed.ncbi.nlm.nih.gov/27150029
https://pubmed.ncbi.nlm.nih.gov/27150029