Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Xiaoxian Gan"'
Autor:
Qingfeng Yu, Ping Wang, Linlin Yang, Zhaoxing Wu, Shu Li, Ying Xu, Bowen Wu, An Ma, Xiaoxian Gan, Rongzhen Xu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 117, Iss , Pp - (2019)
Proto-oncogene Myc, a key transcription factor, is frequently deregulated in human leukemia with aggressive and poor clinical outcome, but the development of MYC inhibitors remains challenging due to MYC helix-loop-helix topology lacking druggable do
Externí odkaz:
https://doaj.org/article/00c32fcc034f4436b3bd8511ca8e0fa6
Autor:
Mengyuan Li, Ying Xu, Xiaofang Yu, Yichao Gan, Ying Gu, Xiaoxian Gan, Bowen Wu, Xuzhao Zhang, Chen Wang, Haifeng Zhuang, Jiawei Zhang, Ping Wang, Jinfan Li, Rongzhen Xu, Linlin Yang, Zhipeng Meng, Wendong Huang, Ganyu Xu, Zhaoxing Wu
Publikováno v:
Aging (Albany NY)
We previously defined the HERV-K Np9 as a viral oncogene. Here we report the discovery of a novel oncogene, Np17, which is homologous to the viral Np9 gene and predominantly present in Hominoidea. Np17 is located on chromosome 8, consists of 7 exons,
Autor:
Ying Xu, Qingfeng Yu, Ping Wang, Zhaoxing Wu, Lei Zhang, Shuigao Wu, Mengyuan Li, Bowen Wu, Hongzhi Li, Haifeng Zhuang, Xuzhao Zhang, Yu Huang, Xiaoxian Gan, Rongzhen Xu
Publikováno v:
Advanced Science. 9:2104344
MYC oncogene is involved in the majority of human cancers and is often associated with poor outcomes, rendering it an extraordinarily desirable target, but therapeutic targeting of c-Myc protein has been a challenge for30 years. Here, WBC100, a novel
Autor:
Xiaoqiong Wang, Zhenzhou Xiao, Walter Tsark, Rongzhen Xu, Lihua Jin, Ying Gu, Min He, Byung-Wook Kim, Xiaoxian Gan, Jiawei Zhang, Hua Yu, Zhipeng Meng, John E. Shively, Xiaoxiao Ma, Wendong Huang, Lili Ding
Publikováno v:
Oncogene
Inflammation is one of the major risk factors for cancer. Here, we show that calcium/calmodulin-dependent protein kinase II gamma (CAMK2γ) in intestinal epithelial cells (IECs) modulates inflammatory signals and promotes colitis-associated cancer (C
Publikováno v:
Biochemical and biophysical research communications. 508(4)
Hepatocellular carcinoma (HCC) is the most prevalent malignancy in liver and a leading cause of cancer-related deaths. Despite the pressing need for treatment options, patients with HCC develop significant resistance and adverse side effects to curre
Autor:
Zhaoxing Wu, Tao Chen, Weiwei Zheng, Ying Gu, Xiaoxian Gan, Xiaoya Lu, Zhipeng Meng, Xiaoxiao Ma, Wendong Huang, Jiawei Zhang, R Xu
Publikováno v:
Leukemia. 30:1282-1289
Blast crisis (BC) is the final deadly phase of chronic myeloid leukemia (CML), but its molecular basis remains poorly understood. Here, we show that CML BC is regulated by calcium-calmodulin-dependent kinase IIγ (CaMKIIγ). Genetic deletion of CaMKI
Autor:
Qi Dong, Rongzhen Xu, Byung-Wook Kim, Xiaoya Lu, Jiawei Zhang, Ying Gu, Xiaoxian Gan, Shu Zheng, Xiaohua Xu, Hong Zhou, Wendong Huang, Weiwei Zheng, Yichao Gan
Publikováno v:
Oncotarget
// Hong Zhou 1, 2, 5, * , Jiawei Zhang 2, 3, * , Ying Gu 1, 2, 3, * , Xiaoxian Gan 3, 4 , Yichao Gan 1, 2 , Weiwei Zheng 1, 2 , Byung-Wook Kim 3 , Xiaohua Xu 1 , Xiaoya Lu 1, 2 , Qi Dong 2 , Shu Zheng 2 , Wendong Huang 3 , Rongzhen Xu 1, 2 1 Departme
Autor:
Xuzhao Zhang, Qingfeng Yu, Ping Wang, Yun Liang, Ying Xu, Linlin Yang, Rongzhen Xu, Zhaoxing Wu, Lei Zhang, Haifeng Zhuang, Bowen Wu, Ying Gu, Xiaoxian Gan, Xiaofang Yu, Jinfan Li, Shu Zheng
Publikováno v:
Experimental Cell Research. 384:111653
Acute myeloid leukemia (AML) is a group of highly aggressive malignancies with a 5-year overall survival of less than 40%. Cell overgrowth with defective apoptosis is a hallmark of AML, but little is known about how it occurs. Here, we show that aber
Autor:
Weiwei Zheng, Ying Gu, Xiaoya Lu, Xiaoxian Gan, Lu Xinliang, Jianghua Chen, Xiaoxiao Ma, Yun Liang, Hong Zhou, Zhipeng Meng, Rongzhen Xu, Ganyu Xu, Yichao Gan, Wendong Huang, X.B. Zhang, Hongzhi Li, Xiaohua Xu, Jiawei Zhang, Xichun Wang
Publikováno v:
Oncotarget
As phospho-eIF4E (p-eIF4E), unlike total eIF4E (t-eIF4E) essential for normal cells, is specifically required by cancer cells, it is an attractive, yet unrealized, target for anti-tumor intervention. Here we identify a small molecule, homoharringtoni
Autor:
Xiaoxian Gan, Zhaoxing Wu, Ping Wang, An Ma, Linlin Yang, Qingfeng Yu, Rongzhen Xu, Bowen Wu, Ying Xu, Shu Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 117, Iss, Pp-(2019)
Proto-oncogene Myc, a key transcription factor, is frequently deregulated in human leukemia with aggressive and poor clinical outcome, but the development of MYC inhibitors remains challenging due to MYC helix-loop-helix topology lacking druggable do