Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Xiaowu, Gai"'
Autor:
Simran Maggo, Liam Y. North, Aime Ozuna, Dejerianne Ostrow, Yander R. Grajeda, Hesamedin Hakimjavadi, Jennifer A. Cotter, Alexander R. Judkins, Pat Levitt, Xiaowu Gai
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
The mitochondrion is a multifunctional organelle that modulates multiple systems critical for homeostasis during pathophysiological stress. Variation in mitochondrial DNA (mtDNA) copy number (mtDNAcn), a key mitochondrial change associated with chron
Externí odkaz:
https://doaj.org/article/c4a5d9846d754dc9bc7df7a2c19feabc
Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors
Autor:
Eirini Christodoulou, Venkata Yellapantula, Katrina O’Halloran, Liya Xu, Jesse L. Berry, Jennifer A. Cotter, Anya Zdanowicz, Leo Mascarenhas, James F. Amatruda, Dejerianne Ostrow, Moiz Bootwalla, Xiaowu Gai, Fariba Navid, Jaclyn A. Biegel
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract We designed a liquid biopsy (LB) platform employing low-pass whole genome sequencing (LP-WGS) and targeted sequencing of cell-free (cf) DNA from plasma to detect genome-wide copy number alterations (CNAs) and gene fusions in pediatric solid
Externí odkaz:
https://doaj.org/article/2d4c69443c07400f8b129c34095fae56
Autor:
Elyssa Y. Wong, Liya Xu, Lishuang Shen, Mary E. Kim, Ashley Polski, Rishvanth K. Prabakar, Rachana Shah, Rima Jubran, Jonathan W. Kim, Jaclyn A. Biegel, Xiaowu Gai, Peter Kuhn, James Hicks, Jesse L. Berry
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-6 (2021)
Abstract Germline alterations in the RB1 tumor suppressor gene predispose patients to develop retinoblastoma (RB) in both eyes. While similar treatment is given for each eye, there is often a variable therapeutic response between the eyes. Herein, we
Externí odkaz:
https://doaj.org/article/cba62b9753aa46e6a2d5607deeabe06c
Autor:
Krieger, Matthew R., Abrahamian, Melania, He, Kevin L., Atamdede, Sean, Hakimjavadi, Hesamedin, Momcilovic, Milica, Ostrow, Dejerianne, Maggo, Simran D. S., Yik Pui Tsang, Xiaowu Gai, Chanfreau, Guillaume F., Shackelford, David B., Teitell, Michael A., Koehler, Carla M.
Publikováno v:
Life Science Alliance; Sep2024, Vol. 7 Issue 9, p1-19, 19p
Autor:
Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 885-893 (2021)
Mutations in the SARS-CoV-2 Membrane (M) gene are relatively uncommon. The M gene encodes the most abundant viral structural protein, and is implicated in multiple viral functions, including initial attachment to the host cell via heparin sulphate pr
Externí odkaz:
https://doaj.org/article/36225cc591ed41b89d2c56eb4a2cafd2
Autor:
Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1293-1299 (2021)
The SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. It is defined by the N501Y mutation in the receptor-binding domain (RBD) of the Spike (S) pro
Externí odkaz:
https://doaj.org/article/f8aa19448b194282a64ae08f50d5999a
Autor:
Maggo, Simran, North, Liam Y., Ozuna, Aime, Ostrow, Dejerianne, Grajeda, Yander R., Hakimjavadi, Hesamedin, Cotter, Jennifer A., Judkins, Alexander R., Levitt, Pat, Xiaowu Gai
Publikováno v:
Frontiers in Pediatrics; 2024, p01-09, 9p
Autor:
Francisco Lopera, Claudia Marino, Anita S. Chandrahas, Michael O’Hare, Nelson David Villalba-Moreno, David Aguillon, Ana Baena, Justin S. Sanchez, Clara Vila-Castelar, Liliana Ramirez Gomez, Natalia Chmielewska, Gabriel M. Oliveira, Jessica Lisa Littau, Kristin Hartmann, Kyungeun Park, Susanne Krasemann, Markus Glatzel, Dorothee Schoemaker, Lucia Gonzalez-Buendia, Santiago Delgado-Tirado, Said Arevalo-Alquichire, Kahira L. Saez-Torres, Dhanesh Amarnani, Leo A. Kim, Randall C. Mazzarino, Harper Gordon, Yamile Bocanegra, Andres Villegas, Xiaowu Gai, Moiz Bootwalla, Jianling Ji, Lishuang Shen, Kenneth S. Kosik, Yi Su, Yinghua Chen, Aaron Schultz, Reisa A. Sperling, Keith Johnson, Eric M. Reiman, Diego Sepulveda-Falla, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz
Publikováno v:
Nature Medicine. 29:1243-1252
We characterized the world’s second case with ascertained extreme resilience to autosomal dominant Alzheimer’s disease (ADAD). Side-by-side comparisons of this male case and the previously reported female case with ADAD homozygote for the APOE3 C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbe347616c0af69e09ef1427cfb6ea9e
https://doi.org/10.1038/s41591-023-02318-3
https://doi.org/10.1038/s41591-023-02318-3
Autor:
Thao T. Truong, Alex Ryutov, Utsav Pandey, Rebecca Yee, Lior Goldberg, Deepa Bhojwani, Paibel Aguayo-Hiraldo, Benjamin A. Pinsky, Andrew Pekosz, Lishuang Shen, Scott D. Boyd, Oliver F. Wirz, Katharina Röltgen, Moiz Bootwalla, Dennis T. Maglinte, Dejerianne Ostrow, David Ruble, Jennifer H. Han, Jaclyn A. Biegel, Maggie Li, ChunHong Huang, Malaya K. Sahoo, Pia S. Pannaraj, Maurice O'Gorman, Alexander R. Judkins, Xiaowu Gai, Jennifer Dien Bard
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103355- (2021)
Background: There is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and subsequent emergence of novel strains with the potential to evade immune responses
Externí odkaz:
https://doaj.org/article/42209873b5b849b2806a3d10b8822b27
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype analysis of 6,356 US isolates, we identified a pattern of strongly localized outbreaks at t
Externí odkaz:
https://doaj.org/article/8bc3c67240da4c278b62c7403755aa51