Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Xiaowen Zou"'
Autor:
Jianwei Jiang, Xiaowen Zou, Yuke Liu, Xiao Liu, Kai Dong, Xiaoqing Yao, Zhiqiang Feng, Xiaoguang Chen, Li Sheng, Yan Li
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
IMMH-010 is a prodrug of YPD-29B, which is a novel PD-L1 inhibitor. A specific and sensitive LC-MS/MS method with polarity switching was developed and validated for the simultaneous determination of IMMH-010 and YPD-29B in rat plasma, liver, brain, u
Externí odkaz:
https://doaj.org/article/828e3e27909b4146926c8e64e6a61373
Autor:
Chenglong Wu, Juan Xu, Han Wang, Jinghua Zhang, Jianhua Zhong, Xiaowen Zou, Yan Chen, Gang Yang, Yuantang Zhong, Daihuan Lai, Xuyi Li, Aifa Tang
Publikováno v:
Kidney & Blood Pressure Research, Vol 42, Iss 5, Pp 853-864 (2017)
Background/Aims: In recent years the diagnosis and management of renal cancer has changed greatly, although the mechanism is still elusive. TMEM106a is a conserved type II transmembrane protein which is a key factor to regulate macrophage activation.
Externí odkaz:
https://doaj.org/article/dcecb15b0b5247f49110c9f594acd1bc
Autor:
Ziqian Zhang, Dandan Liu, Jianwei Jiang, Xiuyun Song, Xiaowen Zou, Shifeng Chu, Kebo Xie, Jungui Dai, Naihong Chen, Li Sheng, Yan Li
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
IMM-H004, a derivative of coumarin, is a promising candidate for the treatment of cerebral ischemia. The pharmacodynamic mechanisms of IMM-H004 are still under exploration. The present study was conducted to explore the pharmacoactive substances of I
Externí odkaz:
https://doaj.org/article/9165015c85e44c2791047530754cd4be
Autor:
Yuchen Wang, Xiao Liu, Xiaowen Zou, Shuting Wang, Lijun Luo, Yuke Liu, Kai Dong, Xiaoqing Yao, Yan Li, Xiaoguang Chen, Li Sheng
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 598 (2021)
IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism of IMMH-010 was investigated and compared in various species. Four metabolites of IMMH-010 were identified, and the major metabolite wa
Externí odkaz:
https://doaj.org/article/fda292145959400c91ba0a20b7c62ba2
Publikováno v:
Issues in Information Systems, Vol 7, Iss 2, Pp 202-207 (2006)
Externí odkaz:
https://doaj.org/article/70bc3cc10b984a628f420bd9c041689e
Publikováno v:
International Journal of Photoenergy, Vol 2014 (2014)
Herein, Ni doped ZnO-TiO2 composites were prepared by facile sol-gel approach and were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), UV-visible diffuse reflectance spectroscopy (UV-Vis DRS), X-ray photoelectron spe
Externí odkaz:
https://doaj.org/article/937ca7bd613947cfb3029c6aa43d138e
Autor:
Hongyi Zhao, Yongxin Gao, Wei Li, Li Sheng, Keli Cui, Bin Wang, Lei Fu, Meng Gao, Ziyun Lin, Xiaowen Zou, Mary Jackson, Haihong Huang, Yu Lu, Dongfeng Zhang
Publikováno v:
Journal of medicinal chemistry. 65(15)
In this work, pyrrole-2-carboxamides were designed with a structure-guided strategy based on the crystal structure of MmpL3 and a pharmacophore model. The structure-activity relationship studies revealed that attaching phenyl and pyridyl groups with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28bcb0daddfe1fc9d8e263c48acb466
https://pubmed.ncbi.nlm.nih.gov/35915958
https://pubmed.ncbi.nlm.nih.gov/35915958
Autor:
Li Sheng, Yan Li, Hua Tian, Yan Zhang, Jing Jin, Jingbo Zhang, Songwen Lin, Deyu Wu, Xiaowen Zou, Nina Xue, Rong Fu, Xiaoguang Chen, Lai Fangfang, Ming Ji, Heng Xu, Kehui Zhang
Publikováno v:
Journal of Medicinal Chemistry. 62:6992-7014
Polypharmacology is a promising paradigm in modern drug discovery. Herein, we have discovered a series of novel PI3K and HDAC dual inhibitors in which the hydroxamic acid moiety as the zinc binding functional group was introduced to a quinazoline-bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ff0f87009621d97fd9052f60984d16
https://doi.org/10.1021/acs.jmedchem.9b00390
https://doi.org/10.1021/acs.jmedchem.9b00390
Publikováno v:
Goldschmidt Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81b8297f91cb2ae69e2ce5af1a2cf960
https://doi.org/10.46427/gold2020.3236
https://doi.org/10.46427/gold2020.3236
Autor:
JIAQIANG LI1,2, XIAOWEN ZOU2,3,4, CAILING LI4, JIANHUA ZHONG2,3, YAN CHEN3, XIAOYUE ZHANG4, FUMING QI2,3, MENGSHUO LI2,3, ZHIMING CAI3, AIFA TANG3 tangaifa2004@163.com
Publikováno v:
Oncology Letters. Apr2017, Vol. 13 Issue 4, p2269-2273. 5p.