Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Xiaowen Lyu"'
Autor:
Yu Zhao, Mengqi Yang, Fanglei Gong, Yuqi Pan, Minghui Hu, Qin Peng, Leina Lu, Xiaowen Lyu, Kun Sun
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-7 (2024)
Abstract The three-dimensional (3D) organization of genome is fundamental to cell biology. To explore 3D genome, emerging high-throughput approaches have produced billions of sequencing reads, which is challenging and time-consuming to analyze. Here
Externí odkaz:
https://doaj.org/article/a4e2fd41e36e4a6aaa3c760f17e0c713
Autor:
Fengqi Qiu, Peishan Jiang, Guiheng Zhang, Jie An, Kexin Ruan, Xiaowen Lyu, Jianya Zhou, Wanqiang Sheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The antitumor efficacy of adoptively transferred T cells is limited by their poor persistence, in part due to exhaustion, but the underlying mechanisms and potential interventions remain underexplored. Here, we show that targeting histone de
Externí odkaz:
https://doaj.org/article/f0039109b23f4b06be07a63165120d6a
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Transcription reprogramming during cell differentiation involves targeting enhancers to genes responsible for establishment of cell fates. To understand the contribution of CTCF-mediated chromatin organization to cell lineage commitment, we
Externí odkaz:
https://doaj.org/article/00e0a254d49a49f2932ed23a536029a6
Publikováno v:
Genes, Vol 13, Iss 12, p 2382 (2022)
The appropriate deployment of developmental programs depends on complex genetic information encoded by genomic DNA sequences and their positioning and contacts in the three-dimensional (3D) space within the nucleus. Current studies using novel techni
Externí odkaz:
https://doaj.org/article/a0f6da2d9f43484797f9e04701c88257
Autor:
Vishnu Dileep, Korey A. Wilson, Claire Marchal, Xiaowen Lyu, Peiyao A. Zhao, Ben Li, Axel Poulet, Daniel A. Bartlett, Juan Carlos Rivera-Mulia, Zhaohui S. Qin, Allan J. Robins, Thomas C. Schulz, Michael J. Kulik, Rachel Patton McCord, Job Dekker, Stephen Dalton, Victor G. Corces, David M. Gilbert
Publikováno v:
Stem Cell Reports, Vol 13, Iss 1, Pp 193-206 (2019)
Summary: The temporal order of DNA replication is regulated during development and is highly correlated with gene expression, histone modifications and 3D genome architecture. We tracked changes in replication timing, gene expression, and chromatin c
Externí odkaz:
https://doaj.org/article/10954ee9cc994312ad7b50a922dfb82d
Autor:
Irene Gutierrez-Perez, M. Jordan Rowley, Xiaowen Lyu, Viviana Valadez-Graham, Diana M. Vallejo, Esther Ballesta-Illan, Jose P. Lopez-Atalaya, Isaac Kremsky, Esther Caparros, Victor G. Corces, Maria Dominguez
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2715-2727.e5 (2019)
Summary: Evidence suggests that Polycomb (Pc) is present at chromatin loop anchors in Drosophila. Pc is recruited to DNA through interactions with the GAGA binding factors GAF and Pipsqueak (Psq). Using HiChIP in Drosophila cells, we find that the ps
Externí odkaz:
https://doaj.org/article/b1134bcf5a3d40e694e695a94bf900ba
Autor:
Yoon Hee Jung, Michael E.G. Sauria, Xiaowen Lyu, Manjinder S. Cheema, Juan Ausio, James Taylor, Victor G. Corces
Publikováno v:
Cell Reports, Vol 18, Iss 6, Pp 1366-1382 (2017)
The mammalian sperm genome is thought to lack substantial information for the regulation of future expression after fertilization. Here, we show that most promoters in mouse sperm are flanked by well-positioned nucleosomes marked by active histone mo
Externí odkaz:
https://doaj.org/article/f605b1eef400437babc5f8cd9f8420ae
Autor:
M. Jordan Rowley, Xiaowen Lyu, Vibhuti Rana, Masami Ando-Kuri, Rachael Karns, Giovanni Bosco, Victor G. Corces
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2890-2903.e3 (2019)
Summary: Interaction domains in Drosophila chromosomes form by segregation of active and inactive chromatin in the absence of CTCF loops, but the role of transcription versus other architectural proteins in chromatin organization is unclear. Here, we
Externí odkaz:
https://doaj.org/article/48a3af521a85462f855f4f5f92bf84d5
Autor:
David M. Gilbert, Shin-ichiro Hiraga, Toyoaki Natsume, Danny Leung, Ipek Tasan, Xuemeng Zhou, Anne D. Donaldson, Meng Zhang, Daniel A. Bartlett, Xiaowen Lyu, Takayo Sasaki, Timour Baslan, Amar M. Singh, Victor G. Corces, Masato T. Kanemaki, Lotte P. Watts, Kyle N. Klein, Stephen Dalton, Huimin Zhao, Peiyao A. Zhao
Publikováno v:
Science
Replication timing organizes epigenome The temporal order of DNA replication is conserved from yeast to humans, but its biological significance remains unclear. Klein et al. eliminated the protein RIF1, a master regulator of replication timing, in se
Autor:
Daniel A. Bartlett, Korey A. Wilson, Xiaowen Lyu, Rachel Patton McCord, Peiyao A. Zhao, David M. Gilbert, Zhaohui S. Qin, Allan J. Robins, Vishnu Dileep, Ben Li, Thomas C. Schulz, Victor G. Corces, Axel Poulet, Stephen Dalton, Claire Marchal, Michael Kulik, Juan Carlos Rivera-Mulia, Job Dekker
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 13, Iss 1, Pp 193-206 (2019)
Stem Cell Reports, Vol 13, Iss 1, Pp 193-206 (2019)
Summary The temporal order of DNA replication is regulated during development and is highly correlated with gene expression, histone modifications and 3D genome architecture. We tracked changes in replication timing, gene expression, and chromatin co