Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Xiaotian T, Fang"'
Autor:
Xiaotian T. Fang, Tommaso Volpi, Sophie E. Holmes, Irina Esterlis, Richard E. Carson, Patrick D. Worhunsky
Publikováno v:
Frontiers in Human Neuroscience, Vol 17 (2023)
Introduction: Resting-state network (RSN) connectivity is a widely used measure of the brain’s functional organization in health and disease; however, little is known regarding the underlying neurophysiology of RSNs. The aim of the current study wa
Externí odkaz:
https://doaj.org/article/71e998c0beaf4f6e9be038437122a32b
Autor:
Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin, Stina Syvänen
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fu
Externí odkaz:
https://doaj.org/article/211db83d4d8c4d658f6944fd83ac6f73
Autor:
Xiaotian T. Fang, Takuya Toyonaga, Ansel T. Hillmer, David Matuskey, Sophie E. Holmes, Rajiv Radhakrishnan, Adam P. Mecca, Christopher H. van Dyck, Deepak Cyril D'Souza, Irina Esterlis, Patrick D. Worhunsky, Richard E. Carson
Publikováno v:
NeuroImage, Vol 237, Iss , Pp 118167- (2021)
Background: The human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations. 11C-UCB-J PET
Externí odkaz:
https://doaj.org/article/b6b00d2267484fc6a95d9f716fc52528
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Imaging tools for evaluating progression of Alzheimer’s disease have been lacking. Here the authors develop a blood brain barrier-permeable Aß probe based on a radiolabelled, anti-Aß antibody, and report age-dependent brain uptake visualized in v
Externí odkaz:
https://doaj.org/article/6ff8814765814c6eabc58af15ab9f554
Autor:
Gillian Bonvicini, Xiaotian T. Fang, Dag Sehlin, Ximena Aguilar, Stina Syvänen, Rebecca Faresjö
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-15 (2021)
Fluids and Barriers of the CNS
Fluids and Barriers of the CNS
Background Transferrin receptor (TfR1) mediated enhanced brain delivery of antibodies have been studied extensively in preclinical settings. However, the brain pharmacokinetics, i.e. brain entry, distribution and elimination are still not fully under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0047630ad43103367e8351ea058cf9
https://doaj.org/article/211db83d4d8c4d658f6944fd83ac6f73
https://doaj.org/article/211db83d4d8c4d658f6944fd83ac6f73
Autor:
Joshua Spurrier, LaShae Nicholson, Xiaotian T. Fang, Austin J. Stoner, Takuya Toyonaga, Daniel Holden, Timothy R. Siegert, William Laird, Mary Alice Allnutt, Marius Chiasseu, A. Harrison Brody, Hideyuki Takahashi, Sarah Helena Nies, Azucena Pérez Cañamás, Pragalath Sadasivam, Supum Lee, Songye Li, Le Zhang, Yiyun H. Huang, Richard E. Carson, Zhengxin Cai, Stephen M. Strittmatter
Publikováno v:
Sci Transl Med
Microglia-mediated synaptic loss contributes to the development of cognitive impairments in Alzheimer’s disease (AD). However, the basis for this immune-mediated attack on synapses remains to be elucidated. Treatment with the metabotropic glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ef758dfb90c7e993eb62d295758a33
https://doi.org/10.1126/scitranslmed.abi8593
https://doi.org/10.1126/scitranslmed.abi8593
Autor:
Ming-Qiang Zheng, Zhengxin Cai, Richard E. Carson, Joshua Spurrier, Yiyun Huang, Supum Lee, Pragalath Sadasivam, Xiaotian T. Fang, Stephen M. Strittmatter, Yuping Xu, Takuya Toyonaga
Publikováno v:
Molecular Imaging and Biology. 23:372-381
Synapse loss is a hallmark of Alzheimer’s disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f8996b50cea2af813fa4b49f8aa8ed7
https://doi.org/10.1007/s11307-020-01567-9
https://doi.org/10.1007/s11307-020-01567-9
Autor:
Stina Syvänen, Johanna Rokka, Xiaotian T. Fang, Dag Erlend Olberg, Lars Lannfelt, Jonas Eriksson, Dag Sehlin, Rebecca Faresjö
Publikováno v:
ACS Chemical Neuroscience
Antibodies are attractive as radioligands due to their outstanding specificity and high affinity, but their inability to cross the blood–brain barrier (BBB) limits their use for CNS targets. To enhance brain distribution, amyloid-β (Aβ) antibodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d3d115d5220e825a8fabd72c72bec2
https://doi.org/10.1021/acschemneuro.0c00652
https://doi.org/10.1021/acschemneuro.0c00652
Autor:
Stina Syvänen, Johanna Rokka, Dag Erlend Olberg, Xiaotian T. Fang, Dag Sehlin, Gunnar Antoni, Lars Lannfelt, Greta Hultqvist, Rebecca Faresjö, Jonas Eriksson
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 62:S5-S122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a77990188eb44479d739b2a49fd89c74
https://doi.org/10.1002/jlcr.3724
https://doi.org/10.1002/jlcr.3724
Autor:
Xiaotian T, Fang, Takuya, Toyonaga, Ansel T, Hillmer, David, Matuskey, Sophie E, Holmes, Rajiv, Radhakrishnan, Adam P, Mecca, Christopher H, van Dyck, Deepak Cyril, D'Souza, Irina, Esterlis, Patrick D, Worhunsky, Richard E, Carson
Publikováno v:
NeuroImage
Background: The human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations. 11C-UCB-J PET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59348a987d8e7331549317ce221aaea2
https://pubmed.ncbi.nlm.nih.gov/34000404
https://pubmed.ncbi.nlm.nih.gov/34000404