Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Xiaosun Guo"'
Autor:
Tengfei Liu, Guopin Pan, Jing Zhang, Jianli Wang, Xiaosun Guo, Ye Chen, Xiaoyun Wang, Xiaopei Cui, Huiqing Liu, Fan Jiang
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37227- (2024)
Our previous studies have shown that the novel selective RNA polymerase I inhibitor CX-5461 suppresses proliferation of vascular smooth muscle cells, mainly by inducing DNA damage response (DDR), including activations of ataxia telangiectasia mutated
Externí odkaz:
https://doaj.org/article/47f5538796374accb3417bae12bd29b2
Autor:
Shasha Lu, Ranran Li, Yunxin Deng, Ju Bai, Bangqi Ji, Yufeng Chu, Yan Xu, Hongping Qu, Xiaosun Guo, Pibao Li, Mei Meng
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Growth differentiation factor 15 (GDF15) as a stress response cytokine is involved in the development and progression of several diseases associated with metabolic disorders. However, the regulatory role and the underlying mechanisms of GDF1
Externí odkaz:
https://doaj.org/article/54545c1e58044f85beae21da28842e62
Autor:
Guopin Pan, Jing Zhang, Yu Han, Ye Chen, Xiaosun Guo, Xiaopei Cui, Mei Cheng, Haiqing Gao, Jianli Wang, Fan Jiang
Publikováno v:
Pharmacological Research, Vol 177, Iss , Pp 106120- (2022)
CX-5461 is a first-in-class selective RNA polymerase I inhibitor. Previously we found that CX-5461 had anti-inflammatory activities. In this study we characterized potential immunosuppressive effects of CX-5461 and explored the underlying mechanisms.
Externí odkaz:
https://doaj.org/article/2e4eb5730e554b4688de821dd961c102
Autor:
Lisha Guo, Mei Meng, Yaping Wei, Feixue Lin, Ying Jiang, Xianzhen Cui, Guirong Wang, Chunting Wang, Xiaosun Guo
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Aims: Clinical studies showed that the use of probiotics during critical illness reduced nosocomial infection and improved clinical outcome. However, the functional mechanisms of probiotics is remains unclear. Therefore the aim of current study is to
Externí odkaz:
https://doaj.org/article/e14beb70fefa4399aa37b49bf9fae431
Publikováno v:
Experimental Dermatology. 32:91-99
Clinical treatment of psoriasis remains challenging because of possible long-term drug toxicities and loss of therapeutic effects over time. CX-5461 is a novel selective inhibitor of RNA polymerase I. Our previous studies have shown that CX-5461 has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd0df47b595ccd24e6aa52c0d5e755a
https://doi.org/10.1111/exd.14682
https://doi.org/10.1111/exd.14682
Autor:
Tengfei Liu, Guopin Pan, Jing Zhang, Jianli Wang, Ye Chen, Xiaoyun Wang, Xiaopei Cui, Xiaosun Guo, Fan Jiang
Background Our previous studies have shown that the novel selective RNA polymerase I inhibitor CX-5461 suppresses proliferation of vascular smooth muscle cells, mainly via induction of activations of ataxia telangiectasia mutated (ATM)/ATM and Rad3-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9b7924f6086a243edd13478c5d28839
https://doi.org/10.21203/rs.3.rs-2541007/v1
https://doi.org/10.21203/rs.3.rs-2541007/v1
Autor:
Kun Luo, Wen Cheng, Xiaosun Guo, Wenjing Zhang, Wencheng Zhang, Rosanna Parlato, Xiaopei Cui, Jianli Wang, Chaochao Dai, Jiankang Zhu, Lei Xu, Min Zhu, Bo Dong, Fan Jiang
Publikováno v:
Aging (Albany NY)
Senescence of smooth muscle cells (SMCs) has a crucial role in the pathogenesis of abdominal aortic aneurysm (AAA), a disease of vascular degeneration. Perturbation of cellular ribosomal DNA (rDNA) transcription triggers nucleolar stress response. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe80fd1edd26806f9a2011106ebd5cd
https://doi.org/10.18632/aging.104094
https://doi.org/10.18632/aging.104094
Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance
Autor:
Ye Chen, Xiao Wu, Jing Zhang, Guopin Pan, Xiaoyun Wang, Xiaosun Guo, Jianli Wang, Xiaopei Cui, Haiqing Gao, Mei Cheng, Jingwen Yang, Cheng Zhang, Fan Jiang
Publikováno v:
EMBO reports. 23(3)
Mammalian cells utilize Akt-dependent signaling to deploy intracellular Glut4 toward cell surface to facilitate glucose uptake. Low-density lipoprotein receptor (LDLR) is the cargo receptor mediating endocytosis of apolipoprotein B-containing lipopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145e4c4ea5833e46e461813780013cb6
https://pubmed.ncbi.nlm.nih.gov/34994492
https://pubmed.ncbi.nlm.nih.gov/34994492
Autor:
Zhenyu Tian, Yu Liu, Mei Meng, Yaping Wei, Fubo Xie, Jingjing Wang, Feng Yan, Qihui Yin, Chaochao Dai, Fan Jiang, Xiaosun Guo, Qunye Zhang, Chang Liu
Publikováno v:
Pharmacological Research. 141:114-122
Previous studies have shown that pretreatment with thapsigargin (TG), a cellular stress inducer, produced potent protective actions against various pathologic injuries. So far there is no information on the effects of TG on the development of bacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f422d9db9fd6d4583fe93a99bba0faa3
https://doi.org/10.1016/j.phrs.2018.12.017
https://doi.org/10.1016/j.phrs.2018.12.017
Autor:
Xiaosun Guo, Wenjing Zhang, Jianli Wang, Tengfei Liu, Fan Jiang, Xiaopei Cui, Ye Chen, Chaochao Dai, Shu Pang
Publikováno v:
European journal of pharmacology. 907
Several lines of studies have indicated that the p53 pathway may have important anti-fibrotic functions. Previously we found that the novel selective RNA polymerase I inhibitor CX-5461 induced a robust response of p53 phosphorylation and activation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15181740f86eb5935a8bdeeaadbbc50d
https://pubmed.ncbi.nlm.nih.gov/34217709
https://pubmed.ncbi.nlm.nih.gov/34217709