Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Xiaosi Han"'
Autor:
Hairui Su, Ming Jiang, Chamara Senevirathne, Srinivas Aluri, Tuo Zhang, Han Guo, Juliana Xavier-Ferrucio, Shuiling Jin, Ngoc-Tung Tran, Szu-Mam Liu, Chiao-Wang Sun, Yongxia Zhu, Qing Zhao, Yuling Chen, LouAnn Cable, Yudao Shen, Jing Liu, Cheng-Kui Qu, Xiaosi Han, Christopher A. Klug, Ravi Bhatia, Yabing Chen, Stephen D. Nimer, Y. George Zheng, Camelia Iancu-Rubin, Jian Jin, Haiteng Deng, Diane S. Krause, Jenny Xiang, Amit Verma, Minkui Luo, Xinyang Zhao
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109421- (2021)
Summary: Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which are tightly regulated during cell differentiation. Using knockdown screening and single-cell transcriptional analysis
Externí odkaz:
https://doaj.org/article/c390eca951f14661aa1b8d2ec69d2ff2
Autor:
Eric K. Ring, Rong Li, Blake P. Moore, Li Nan, Virginia M. Kelly, Xiaosi Han, Elizabeth A. Beierle, James M. Markert, Jianmei W. Leavenworth, G. Yancey Gillespie, Gregory K. Friedman
Publikováno v:
Molecular Therapy: Oncolytics, Vol 7, Iss , Pp 27-36 (2017)
Despite advances in conventional chemotherapy, surgical techniques, and radiation, outcomes for patients with relapsed, refractory, or metastatic soft tissue sarcomas are dismal. Survivors often suffer from lasting morbidity from current treatments.
Externí odkaz:
https://doaj.org/article/1ff8a3f147d24fc3b38ed16da408b973
Autor:
Zhong Liu, Cheng Zhang, Maria Skamagki, Alireza Khodadadi-Jamayran, Wei Zhang, Dexin Kong, Chia-Wei Chang, Jingyang Feng, Xiaosi Han, Tim M. Townes, Hu Li, Kitai Kim, Rui Zhao
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1604-1617 (2017)
Summary: Pluripotent stem cells (PSCs) deficient for microRNAs (miRNAs), such as Dgcr8−/− or Dicer−/– embryonic stem cells (ESCs), contain no mature miRNA and cannot differentiate into somatic cells. How miRNA deficiency causes differentiatio
Externí odkaz:
https://doaj.org/article/fe69fd9c1cce436280476766fcc5a2a9
Autor:
Kai Chen, Yingnan Si, Jianfa Ou, Jia-Shiung Guan, Seulhee Kim, Patrick Ernst, Ya Zhang, Lufang Zhou, Xiaosi Han, Xiaoguang (Margaret) Liu
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 427 (2021)
Meningiomas are primary tumors of the central nervous system with high recurrence. It has been reported that somatostatin receptor 2 (SSTR2) is highly expressed in most meningiomas, but there is no effective targeted therapy approved to control menin
Externí odkaz:
https://doaj.org/article/2b6a3012228a4e1bad9f7acca5a13f3d
Autor:
Pulin Che, Lei Yu, Gregory K. Friedman, Meimei Wang, Xiaoxue Ke, Huafeng Wang, Wenbin Zhang, Burt Nabors, Qiang Ding, Xiaosi Han
Publikováno v:
Cancers, Vol 13, Iss 5, p 1111 (2021)
Metabolic reprogramming promotes glioblastoma cell migration and invasion. Integrin αvβ3 is one of the major integrin family members in glioblastoma multiforme cell surface mediating interactions with extracellular matrix proteins that are importan
Externí odkaz:
https://doaj.org/article/dfd72773ce254fb9995606bd35858c81
Autor:
Hassan M Fathallah-Shaykh, Andrew DeAtkine, Elizabeth Coffee, Elias Khayat, Asim K Bag, Xiaosi Han, Paula Province Warren, Markus Bredel, John Fiveash, James Markert, Nidhal Bouaynaya, Louis B Nabors
Publikováno v:
PLoS Medicine, Vol 16, Iss 5, p e1002810 (2019)
BackgroundLow-grade gliomas cause significant neurological morbidity by brain invasion. There is no universally accepted objective technique available for detection of enlargement of low-grade gliomas in the clinical setting; subjective evaluation by
Externí odkaz:
https://doaj.org/article/e441b3800dc947889c741a43b9a773a6
Publikováno v:
SAGE Open Medical Case Reports, Vol 5 (2017)
Objectives: This case report describes two cases of high-dose methotrexate–induced nephrotoxicity: death in the case of conventional supportive care and successful renal function recovery in a patient treated with glucarpidase and continuous dialys
Externí odkaz:
https://doaj.org/article/82951d505c394e35a6103ab6686b060d
Autor:
Xue-Ke Zhao, Pulin Che, Ming-Liang Cheng, Quan Zhang, Mao Mu, Hong Li, Yuan Luo, Yue-Dong Liang, Xin-Hua Luo, Chang-Qing Gao, Patricia L Jackson, J Michael Wells, Yong Zhou, Meng Hu, Guoqiang Cai, Victor J Thannickal, Chad Steele, J Edwin Blalock, Xiaosi Han, Ching-Yi Chen, Qiang Ding
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167451 (2016)
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TT
Externí odkaz:
https://doaj.org/article/f6e719c7215c425cbbbf0b028f485380
Autor:
Li Zhang, Ngoc-Tung Tran, Hairui Su, Rui Wang, Yuheng Lu, Haiping Tang, Sayura Aoyagi, Ailan Guo, Alireza Khodadadi-Jamayran, Dewang Zhou, Kun Qian, Todd Hricik, Jocelyn Côté, Xiaosi Han, Wenping Zhou, Suparna Laha, Omar Abdel-Wahab, Ross L Levine, Glen Raffel, Yanyan Liu, Dongquan Chen, Haitao Li, Tim Townes, Hengbin Wang, Haiteng Deng, Y George Zheng, Christina Leslie, Minkui Luo, Xinyang Zhao
Publikováno v:
eLife, Vol 4 (2015)
RBM15, an RNA binding protein, determines cell-fate specification of many tissues including blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1) at residue R578, leading to its degradation via ubiquitylation
Externí odkaz:
https://doaj.org/article/5c58a02b0b8046cdaa1d8e719d026b86
Autor:
Kyung-Don Kang, Joshua D. Bernstock, Stacie K. Totsch, Sam E. Gary, Abbey Rocco, Li Nan, Rong Li, Tina Etminan, Xiaosi Han, Elizabeth A. Beierle, Tanja Eisemann, Robert J. Wechsler-Reya, Sejong Bae, Richard Whitley, G. Yancey Gillespie, James M. Markert, Gregory K. Friedman
Publikováno v:
Clin Cancer Res
Purpose: Oncolytic virotherapy with herpes simplex virus-1 (HSV) has shown promise for the treatment of pediatric and adult brain tumors; however, completed and ongoing clinical trials have utilized intratumoral/peritumoral oncolytic HSV (oHSV) inocu