Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Xiaoshu Dai"'
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Akademický článek
Mass balance and pharmacokinetics of an oral dose of 14C‐napabucasin in healthy adult male subjects
Autor: Xiaoshu Dai, Michael D. Karol, Matthew Hitron, Marjie L. Hard, John Evan Blanchard, Nicola C. J. E. Eraut, Natalie Rich, Brandon T. Gufford
Publikováno v: Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
Abstract This phase 1, open‐label study assessed14C‐napabucasin absorption, metabolism, and excretion, napabucasin pharmacokinetics, and napabucasin metabolites (primary objectives); safety/tolerability were also evaluated. Eight healthy males (1
Externí odkaz: https://doaj.org/article/10ac3b8997ef4b199f99a49697b69367
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2
Napabucasin Drug‐Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers
Autor: Matthew Hitron, Michael D. Karol, Marjie L. Hard, Xiaoshu Dai, Colleen F. Mclaughlin, Scott J. Brantley, Matthew T. Goulet
Publikováno v: Clinical Pharmacology in Drug Development
Napabucasin is an orally administered reactive oxygen species generator that is bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1. Napabucasin induces cell death in cancer cells, includ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd249a6a220f2dc5c28a0e4212bd82e9
http://europepmc.org/articles/PMC8453567
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4
Mass balance and pharmacokinetics of an oral dose of 14C‐napabucasin in healthy adult male subjects
Autor: Michael D. Karol, John Evan Blanchard, Marjie L. Hard, Xiaoshu Dai, Nicola C. J. E. Eraut, Matthew Hitron, Brandon T. Gufford, Natalie Rich
Publikováno v: Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
This phase 1, open‐label study assessed14C‐napabucasin absorption, metabolism, and excretion, napabucasin pharmacokinetics, and napabucasin metabolites (primary objectives); safety/tolerability were also evaluated. Eight healthy males (18–45 ye
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baa79bca5df8219168c7ac0b9604da9
http://europepmc.org/articles/PMC7878185
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5
Effect of food on exposure to napabucasin: Data from two phase I studies
Autor: Michael D. Karol, Bo Xu, Xiaoshu Dai, Yuran Xie, Naoto Noda, Matthew Hitron
Publikováno v: Journal of Clinical Oncology. 39:477-477
477 Background: Napabucasin is an orally-administered NAD(P)H quinone dehydrogenase 1–bioactivatable investigational agent hypothesized to affect multiple oncogenic cellular pathways including STAT3. Methods: Food effects on napabucasin pharmacokin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1808d4a16c0729152a257bbcff728588
https://doi.org/10.1200/jco.2021.39.3_suppl.477
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6
Drug-drug interaction (DDI) potential of oral napabucasin in healthy adults
Autor: Michael D. Karol, Marjie L. Hard, Scott J. Brantley, Xiaoshu Dai, Matthew T. Goulet, Colleen F. Mclaughlin, Matthew Hitron
Publikováno v: Journal of Clinical Oncology. 38:142-142
142 Background: Napabucasin is an NQO1-bioactivatable investigational agent hypothesized to affect multiple oncogenic cellular pathways including pSTAT3 through the generation of reactive oxygen species. This phase 1 open-label study evaluated the DD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fba3583533ad2021968f62cf1ae4f80
https://doi.org/10.1200/jco.2020.38.4_suppl.142
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7
Abstract A113: Mass balance and pharmacokinetics of an oral dose of 14C-napabucasin in healthy adult male subjects
Autor: Nicola C. J. E. Eraut, Brandon T. Gufford, Marjie L. Hard, Xiaoshu Dai, Natalie Rich, Matthew Hitron, J Evan Blanchard, Michael D Karol
Publikováno v: Molecular Cancer Therapeutics. 18:A113-A113
Introduction: Napabucasin is an NQO1-bioactivatable investigational agent hypothesized to affect multiple oncogenic cellular pathways including pSTAT3 through the generation of reactive oxygen species. The primary objectives of this phase 1, open-lab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb94f5631ae713d0543ba02684a5610b
https://doi.org/10.1158/1535-7163.targ-19-a113
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8
Akademický článek
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9
Staining and Etching: A Simple Method to Fabricate Inorganic Nanostructures from Tissue Slices
Autor: Richard Schalek, Xiaoshu Dai, Qiaobing Xu
Publikováno v: Advanced Materials. 24:370-374
Staining and etching is developed for the fabrication of two-dimensional arrays and three-dimensional foam-like metallic nanostructures from a piece of tissue using a combination of metal staining and oxygen plasma etching. This novel nanofabrication
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05bfda89ba76abbbc58883d0decdaa6
https://doi.org/10.1002/adma.201103908
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