Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Xiaoshen Ma"'
Autor:
Xiaoshen Ma, Seth B. Herzon
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2259-2265 (2018)
We show that cobalt bis(acetylacetonate) [Co(acac)2], tert-butyl hydroperoxide (TBHP), and triethylsilane (Et3SiH) constitute an inexpensive, general, and practical reagent combination to initiate a broad range of Markovnikov-selective alkene hydrofu
Externí odkaz:
https://doaj.org/article/7a1c736df202433ebeffbf3dacfd5a77
Autor:
Yunying Cui, Yushi Zhang, Jie Ding, Huiping Wang, Xiaoshen Ma, Ou Wang, Xiaoyan Chang, Hao Sun, Li Huo, Anli Tong
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Context: Primary aldosteronism represents an important and common cause of hypertension and is characterized by autonomous aldosterone secretion that results in severe hypertension and hypokalemia. Nonetheless, its manifestations are atypical in some
Externí odkaz:
https://doaj.org/article/58322c819f524de08a9c55a8cd408781
Autor:
Yuan Jiang, Xiaoshen Ma
Publikováno v:
The Journal of Organic Chemistry. 88:1665-1694
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f50f7fdad1e0369c512f79c2a40493b5
https://doi.org/10.1021/acs.joc.2c02701
https://doi.org/10.1021/acs.joc.2c02701
Autor:
Olivia L. Garry, Michael Heilmann, Jingjia Chen, Yufan Liang, Xiaheng Zhang, Xiaoshen Ma, Charles S. Yeung, David Jonathan Bennett, David W. C. MacMillan
Publikováno v:
Journal of the American Chemical Society. 145:3092-3100
The replacement of aryl rings with C(sp3)-rich structures has garnered significant interest in drug discovery due to the potential for improved pharmacokinetic properties upon substitution. In particular, 1,3-difunctionalized bicyclo[1.1.1]pentanes (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f0a159ca5ba797e4afbfe50fa4a662
https://doi.org/10.1021/jacs.2c12163
https://doi.org/10.1021/jacs.2c12163
Autor:
Mario P. Wiesenfeldt, James A. Rossi-Ashton, Ian B. Perry, Johannes Diesel, Olivia L. Garry, Florian Bartels, Susannah C. Coote, Xiaoshen Ma, Charles S. Yeung, David J. Bennett, David W. C. MacMillan
Publikováno v:
Nature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ba0905b116e54a0542574dae1ebb3b
https://doi.org/10.1038/s41586-023-06021-8
https://doi.org/10.1038/s41586-023-06021-8
Autor:
Mario P. Wiesenfeldt, James. A. Rossi-Ashton, Ian B. Perry, Johannes Diesel, Olivia L. Garry, Florian Bartels, Susannah C. Coote, Xiaoshen Ma, Charles S. Yeung, David Jonathan Bennett, David W. C. MacMillan
The replacement of benzene rings with sp3-hybridized bioisosteres in drug candidates generally improves pharmacokinetic properties while retaining biological activity. Rigid, strained frameworks such as bicyclo[1.1.1]pentane and cubane are particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53173ca3a5e2b1a0bc1580afb60e1d8c
https://doi.org/10.26434/chemrxiv-2023-89jlx
https://doi.org/10.26434/chemrxiv-2023-89jlx
Autor:
Xiaoshen Ma, Yuan Jiang
We describe a general transition-metal free synthesis of gem-diboromethyl substituted bicyclo[1.1.1]pentane (BCP) and other related C(sp3)-rich carbocyclic benzene bioisosteres from their corresponding p-tosylhydrazones. These novel functionalized be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5050f14fd26113b913c1de4069a253b
https://doi.org/10.26434/chemrxiv-2022-96vc8
https://doi.org/10.26434/chemrxiv-2022-96vc8
Autor:
Xiaoshen Ma, Charles S. Yeung
Publikováno v:
The Journal of Organic Chemistry. 86:10672-10698
We report our efforts toward achieving C(sp2)-C(sp3) coupling reactions with 2,2-difluorobicyclo[1.1.1]pentane (BCP-F2) building blocks. By comparing the reactivities of matching pairs of bicyclo[1.1.1]pentane (BCP) and BCP-F2 analogues, we discovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b3b79125f0854087297469fd6512ab
https://doi.org/10.1021/acs.joc.1c01370
https://doi.org/10.1021/acs.joc.1c01370
Publikováno v:
European Journal of Organic Chemistry. 2020:4581-4605
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607d2b22f0ab574bca83441feca1e491
https://doi.org/10.1002/ejoc.202000679
https://doi.org/10.1002/ejoc.202000679
Autor:
Luu Nhat Pham, Xiaoshen Ma
Publikováno v:
Asian Journal of Organic Chemistry. 9:8-22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67bbecd0d108c1f58fef4f29c7bc368d
https://doi.org/10.1002/ajoc.201900589
https://doi.org/10.1002/ajoc.201900589