Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Xiaoshan Min"'
Genetic analysis assists diagnosis of clinical systemic disease in children with excessive hyperopia
Publikováno v:
BMC Pediatrics, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Background A thorough examination (especially those including visual functional evaluation) is very important in children’s eye-development during clinical practice, when they encountered with unusual excessive hyperopia especially accompa
Externí odkaz:
https://doaj.org/article/a4152c9c4b134406a5b4628ce7e99acd
Autor:
Hanzhi Zhang, Ching-Shin Huang, Xinchao Yu, Jonas Lee, Amit Vaish, Qing Chen, Mingyue Zhou, Zhulun Wang, Xiaoshan Min
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Zhang et al. present the cryo-EM structure of ATP-binding cassette transporters ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3.3 Å resolution. This study provides structural insights into the transport cycle and poten
Externí odkaz:
https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f3
Autor:
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. Véniant, Zhulun Wang
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharmacological i
Externí odkaz:
https://doaj.org/article/968f0a3d32354e02bad2c843bdc326da
Publikováno v:
Journal of Ophthalmology, Vol 2020 (2020)
Objectives. To summarize the clinical manifestations, diagnosis, treatment, and prognosis for inferior oblique muscle ectopia (IO-E). Subjects and Methods. Patients diagnosed with IO-E during strabismus surgery from March 2017 to September 2018 were
Externí odkaz:
https://doaj.org/article/094b875ed4914e72bbc9b9eeb105e133
Autor:
Alan C. Cheng, Elizabeth M. Doherty, Sheree Johnstone, Erin F. DiMauro, Jennifer Dao, Abhinav Luthra, Jay Ye, Jie Tang, Thomas Nixey, Xiaoshan Min, Philip Tagari, Les P. Miranda, Zhulun Wang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Small molecules and antibodies each have advantages and limitations as therapeutics. Here, we present for the first time to our knowledge, the structure-guided design of “chemibodies” as small molecule-antibody hybrids that offer dual re
Externí odkaz:
https://doaj.org/article/03c054e59aee48aa9fd15ab0e960b901
Publikováno v:
Journal of Ophthalmology, Vol 2018 (2018)
Aim. Conjunctival cyst is one of the uncommon complications of strabismus surgery. It is important for surgeons and patients to be aware of and take precautions to minimize the risk. This study aimed to explore the clinical manifestations, etiology,
Externí odkaz:
https://doaj.org/article/df42703902194739b1fe697e5091b40e
Autor:
Amit Vaish, Zhulun Wang, Xiaoshan Min, Ching-Shin Huang, Jonas Lee, Xinchao Yu, Mingyue Zhou, Qing Chen, Hanzhi Zhang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology
Communications Biology
The heterodimer of ATP-binding cassette transporter ABCG5 and ABCG8 mediates the excretion of sterols from liver and intestine, playing a critical role in cholesterol homeostasis. Here, we present the cryo-EM structure of ABCG5/G8 in complex with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebc2c4ebf287433b9a8c309ff1e954f
https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f3
https://doaj.org/article/89adae28264f40d7b90ec8bef59c63f3
Autor:
Mercedesz Balazs, Alexander Sternjak, Edwin Lamas, Ana Goyos, Petra Deegen, Benno Rattel, Joachim Wahl, Mozhgan Farshbaf, Angela Coxon, Xiaoshan Min, Tara Arvedson, Matthias Klinger, Oliver Thomas, Chi-Ming Li, Pamela Bogner, Matthias Friedrich, Rebecca Goldstein, Athena Sudom
Publikováno v:
Blood Adv
Multiple myeloma (MM) is a hematologic malignancy that is characterized by the accumulation of abnormal plasma cells (PCs) in the bone marrow (BM). Patient outcome may be improved with BiTE (bispecific T-cell engager) molecules, which redirect T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061bce601b28f7542a249899194e4070
https://doi.org/10.1182/bloodadvances.2020002565
https://doi.org/10.1182/bloodadvances.2020002565
Autor:
John T Barr, Henry J Wienkers, Brooke M. Rock, Zhican Wang, Dan A. Rock, Larry C. Wienkers, Xiaoshan Min
Publikováno v:
Drug Metabolism and Disposition. 48:508-514
Experiments designed to identify the mechanism of cytochrome P450 inactivation are critical to drug discovery. Small molecules irreversibly inhibit P450 enzymatic activity via two primary mechanisms: apoprotein adduct formation or heme modification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee45a877b4b2b24541954c1b9c51f60b
https://doi.org/10.1124/dmd.119.089813
https://doi.org/10.1124/dmd.119.089813
Autor:
Agnieszka Kielczewska, Igor D'Angelo, Maria Sheena Amador, Tina Wang, Athena Sudom, Xiaoshan Min, Palaniswami Rathanaswami, Craig Pigott, Ian N. Foltz
Publikováno v:
The Journal of biological chemistry. 298(2)
Therapeutic antibody development requires discovery of an antibody molecule with desired specificities and drug-like properties. For toxicological studies, a therapeutic antibody must bind the ortholog antigen with a similar affinity to the human tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271ee90fc2b9177d1e7f2e6b08b4abdf
https://pubmed.ncbi.nlm.nih.gov/34973336
https://pubmed.ncbi.nlm.nih.gov/34973336