Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Xiaorou Guo"'
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100367- (2023)
For the past 20 years, the majority of cell culture studies reported that increasing cholesterol level increases amyloid-β (Aβ) production. Conversely, other studies and genetic evidences support that cellular cholesterol loss leads to Aβ generati
Externí odkaz:
https://doaj.org/article/495718290d0a4da39724cd92933bf584
Autor:
Xiaojing Bai, Meiting Mai, Kai Yao, Mengqi Zhang, Yue Huang, Wenbin Zhang, Xiaorou Guo, Yixuan Xu, Ying Zhang, Atikam Qurban, Lijie Duan, Jimei Bu, Jianfeng Zhang, Junfeng Wu, Yongfei Zhao, Xiangshan Yuan, Hengbing Zu
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Previous studies show that 3β-hydroxysterol-Δ24 reductase (DHCR24) has a remarked decline in the brain of AD patients. In brain cholesterol synthetic metabolism, DHCR24 is known as the heavily key synthetase in cholesterol synthesis. Moreo
Externí odkaz:
https://doaj.org/article/c0a9f29d1d974b218b9e70e8eab3c9fc
Autor:
Meiting Mai, Xiaorou Guo, Yue Huang, Wenbin Zhang, Yixuan Xu, Ying Zhang, Xiaojing Bai, Junfeng Wu, Hengbing Zu
Publikováno v:
Molecular Neurobiology. 59:5856-5873
The synthetase 3β-hydroxysterol-Δ24 reductase (DHCR24) is a key regulator involved in cholesterol synthesis and homeostasis. A growing body of evidence indicates that DHCR24 is downregulated in the brain of various models of Alzheimer’s disease (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cb21bcd57ff76313a908a46b9997e8
https://doi.org/10.1007/s12035-022-02945-w
https://doi.org/10.1007/s12035-022-02945-w
Autor:
Qingwang Chen, Xiaorou Guo, Haiyan Wang, Shanyue Sun, He Jiang, Peipei Zhang, Erfei Shang, Ruolan Zhang, Zehui Cao, Quanne Niu, Chao Zhang, Yaqing Liu, Yuanting Zheng, Ying Yu, Wanwan Hou, Leming Shi
RNA sequencing (RNAseq) technology has become increasingly important in precision medicine and clinical diagnostics and emerged as a powerful tool for identifying protein-coding genes, performing differential gene analysis, and inferring immune cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f206ab15bc810b81436cfc553c9aa849
https://doi.org/10.1101/2023.04.27.538178
https://doi.org/10.1101/2023.04.27.538178
Autor:
Mengqi, Zhang, Fengmin, Huang, Feiyu, Jiang, Meiting, Mai, Xiaorou, Guo, Ying, Zhang, Ying, Xu, Hengbing, Zu
Publikováno v:
Medicine. 101:e31201
Clinical and animal studies have reported that low-dose doxepin may have positive effects on generalized anxiety disorder (GAD); however, its effectiveness and clinical safety are less well understood. This study is a before-after study and aims to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ad93f1a05f1dff66be800a05cf111b
https://doi.org/10.1097/md.0000000000031201
https://doi.org/10.1097/md.0000000000031201