Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Xiaorong Xu, Parks"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Braun et al. investigate the effects of PI 4-kinases and their lipid product, PI4P, in KCNQ channel function and sub-cellular localization. These results suggest a possible harmful effect of PI4K inhibition on cardiac electrophysiology and suggest th
Externí odkaz:
https://doaj.org/article/8c9886eab66a4d82823f36e53795ed0a
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237591 (2020)
The slow cardiac delayed rectifier current (IKs) is formed by KCNQ1 and KCNE1 subunits and is one of the major repolarizing currents in the heart. Decrease of IKs currents either due to inherited mutations or pathological remodeling is associated wit
Externí odkaz:
https://doaj.org/article/cb0812d4f775420dae3624be5df939bd
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
In turtle posterior cristae, cholinergic vestibular efferent neurons (VENs) synapse on type II hair cells, bouton afferents innervating type II hair cells, and afferent calyces innervating type I hair cells. Electrical stimulation of VENs releases ac
Externí odkaz:
https://doaj.org/article/435715f39d7c4aef888e1f4b99ee04d0
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Statins are prescribed for prevention and treatment of coronary artery disease. Statins have different cholesterol lowering abilities, with rosuvastatin and atorvastatin being the most effective, while statins like simvastatin and fluvastatin having
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81dbaaf86904899d93fae48f5bea6d7
http://link.springer.com/article/10.1038/s41598-019-53700-6
http://link.springer.com/article/10.1038/s41598-019-53700-6
Publikováno v:
Journal of Molecular and Cellular Cardiology. 129:314-325
Statins, in addition to their cholesterol lowering effects, can prevent isoprenylation of Rab GTPase proteins, a key protein family for the regulation of protein trafficking. Rab-GTPases have been shown to be involved in the control of membrane expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdb0f154afec05b14574a55239ecadce
https://doi.org/10.1016/j.yjmcc.2019.03.016
https://doi.org/10.1016/j.yjmcc.2019.03.016
Autor:
Pornthida Poosala, Douglas M Anderson, Sean Lindley, Xiaorong Xu Parks, Kelly M Anderson, Coeli M. Lopes
Publikováno v:
Circulation Research. 125
Voltage-gated potassium (K + ) channels (VGKCs) are essential regulators of the cardiac action potential and are required to maintain normal heart rhythm and contractility. Voltage-dependent activation, conductance and membrane trafficking of K + cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c30384e0c9b9a1a357757bcfbda5623
https://doi.org/10.1161/res.125.suppl_1.235
https://doi.org/10.1161/res.125.suppl_1.235
Publikováno v:
Journal of molecular and cellular cardiology. 138
The slow voltage-gated potassium channel (IKs) is composed of the KCNQ1 and KCNE1 subunits and is one of the major repolarizing currents in the heart. Activation of protein kinase C (PKC) has been linked to cardiac arrhythmias. Although PKC has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db32de8cb169cfbec496974c2ff220e
https://pubmed.ncbi.nlm.nih.gov/31785237
https://pubmed.ncbi.nlm.nih.gov/31785237
Publikováno v:
Journal of molecular and cellular cardiology. 129
Statins, in addition to their cholesterol lowering effects, can prevent isoprenylation of ab GTPase proteins, a key protein family for the regulation of protein trafficking. Rab-GTPases have been shown to be involved in the control of membrane expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c2765dccc8c9b58dd4d315c64b5525c
https://pubmed.ncbi.nlm.nih.gov/30898664
https://pubmed.ncbi.nlm.nih.gov/30898664
Autor:
Coeli M. Lopes, Martin H. Ruwald, Arthur J. Moss, Jayson R. Baman, Xiaorong Xu Parks, Wataru Shimizu, Scott McNitt, Jørgen K. Kanters, Wojciech Zareba, Christian Jons, Arthur A.M. Wilde
Publikováno v:
Heart rhythm, 13(1), 122-131. Elsevier
Background In long QT syndrome type 1 (LQT1), the location and type of mutations have been shown to affect the clinical outcome. Although haploinsufficiency, including stop-codon and frameshift mutations, has been associated with a lower risk of card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e046a7d1f2e6fcbd3369a3bcef57a58c
https://doi.org/10.1016/j.hrthm.2015.08.033
https://doi.org/10.1016/j.hrthm.2015.08.033
Autor:
Xiaorong Xu Parks, Coeli M. Lopes, Wojciech Zareba, Arthur J. Moss, Jin O-Uchi, Elsa Ronzier, Martin H. Ruwald, John Rice
Publikováno v:
Journal of Molecular and Cellular Cardiology. 79:203-211
Background The most common inherited cardiac arrhythmia, LQT1, is due to IKs potassium channel mutations and is linked to high risk of adrenergic-triggered cardiac events. We recently showed that although exercise-triggered events are very well treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd68d86e8eac7af4ef968fac9b44295
https://doi.org/10.1016/j.yjmcc.2014.11.020
https://doi.org/10.1016/j.yjmcc.2014.11.020