Výsledky vyhledávání - "Xiaorong Liang"

Akademický článek

Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection

Publikováno v: mBio, Vol 15, Iss 10 (2024)

ABSTRACT Guanine nucleotides are required for growth and viability of cells due to their structural role in DNA and RNA, and their regulatory roles in translation, signal transduction, and cell division. The natural antibiotic mycophenolic acid (MPA)

Externí odkaz: https://doaj.org/article/92da914a1cc64fff8b2ab55b0e41acbf

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Akademický článek

Effects of thermal annealing on the spin–orbit torque and unidirectional spin Hall magnetoresistance in Pt/CoFe/Ta trilayers

Autor: Guonan Feng, Di Fu, Xi Chen, Jintao Liu, Xinyan Yang, Xiaorong Liang, Penghao Lv, Di Zhao, Minggao Zuo, Guanghua Yu

Publikováno v: AIP Advances, Vol 13, Iss 5, Pp 055022-055022-8 (2023)

We investigated the spin–orbit torque (SOT) and unidirectional spin Hall magnetoresistance (USMR) in Pt/CoFe/Ta trilayer as well as Pt/CoFe and CoFe/Ta bilayers with in-plane magnetic anisotropy by performing transverse and longitudinal second harm

Externí odkaz: https://doaj.org/article/c8f33b2f704846e291a48c205255957b

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Akademický článek

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)

Abstract Background Indoleamine-2,3-dioxygenase 1 (IDO1) catalyzes the oxidation of tryptophan into kynurenine and is partially responsible for acquired immune tolerance associated with cancer. The IDO1 small molecule inhibitor navoximod (GDC-0919, N

Externí odkaz: https://doaj.org/article/fa3f41ad888d41f5a1c759f8b6fa21b2

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Akademický článek

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

Autor: Thomas O'Brien, Jason Oeh, Yang Xiao, Xiaorong Liang, Alexander Vanderbilt, Ann Qin, Lulu Yang, Leslie B. Lee, Justin Ly, Ely Cosino, Jennifer A. LaCap, Annie Ogasawara, Simon Williams, Michelle Nannini, Bianca M. Liederer, Peter Jackson, Peter S. Dragovich, Deepak Sampath

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 12, Pp 1314-1329 (2013)

Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway. Altern

Externí odkaz: https://doaj.org/article/8535a58d3d9848dc8bfb8adf33b8bae4

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Akademický článek

Dependence of Tumor Cell Lines and Patient-Derived Tumors on the NAD Salvage Pathway Renders Them Sensitive to NAMPT Inhibition with GNE-618

Autor: Yang Xiao, Kristi Elkins, Jenni K Durieux, Leslie Lee, Jason Oeh, Lulu X Yang, Xiaorong Liang, Chris DelNagro, Jarrod Tremayne, Mandy Kwong, Bianca M Liederer, Peter K Jackson, Lisa D Belmont, Deepak Sampath, Thomas O'Brien

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 10, Pp 1151-1160 (2013)

Nicotinamide adenine dinucleotide (NAD) is a critical metabolite that is required for a range of cellular reactions. A key enzyme in the NAD salvage pathway is nicotinamide phosphoribosyl transferase (NAMPT), and here, we describe GNE-618, an NAMPT i

Externí odkaz: https://doaj.org/article/465978c254fd40a9b156667dad2f834b

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Akademický článek

Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable.

Autor: Yang Xiao, Mandy Kwong, Anneleen Daemen, Marcia Belvin, Xiaorong Liang, Georgia Hatzivassiliou, Thomas O'Brien

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164166 (2016)

Nicotinamide adenine dinucleotide (NAD) is a cofactor involved in a wide range of cellular metabolic processes and is a key metabolite required for tumor growth. NAMPT, nicotinamide phosphoribosyltransferase, which converts nicotinamide (NAM) to nico

Externí odkaz: https://doaj.org/article/08f009d776a44cfe94cd8439ba127613

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Bariatric surgery reduces sleep apnea in obese patients with obstructive sleep apnea by increasing pharyngeal cross-sectional area during the early postoperative period

Autor: Yuliang Zhao, Tao Li, Guangyuan Zhang, Xiaorong Liang, Yanxia Wang, Jiansheng Kang, Jiangang Ma

Publikováno v: European Archives of Oto-Rhino-Laryngology. 280:2435-2443

Objective Bariatric surgery (BS) is considered one of the most effective treatments for obese individuals with Obstructive Sleep Apnea (OSA). However, otolaryngologists have raised concerns about the structural alterations caused by BS on the upper r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f2a6ade4abea46f06101850ff868afa
https://doi.org/10.1007/s00405-023-07821-4

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Volumetric absorptive microsampling–LC–MS/MS assays for quantitation of giredestrant in dried human whole blood

Autor: Ryan Johnson, Imran Rehmani, Mark Leahy, Abigail Walker, Xiaorong Liang, Brian Dean, Jianshuang Wang

Publikováno v: Bioanalysis. 14:1377-1389

Volumetric absorption microsampling devices offer minimally invasive and user-friendly collection of capillary blood in volumes as low as 10 μl. Herein we describe the assay validation for determination of the selective estrogen receptor degrader gi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85496617a46ed186e9c4c922ce90f576
https://doi.org/10.4155/bio-2022-0189

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