Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Xiaoping Hronowski"'
Autor:
Melanie S Brennan, Maria F Matos, Bing Li, Xiaoping Hronowski, Benbo Gao, Peter Juhasz, Kenneth J Rhodes, Robert H Scannevin
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120254 (2015)
Delayed-release dimethyl fumarate (also known as gastro-resistant dimethyl fumarate), an oral therapeutic containing dimethyl fumarate (DMF) as the active ingredient, is currently approved for the treatment of relapsing multiple sclerosis. DMF is als
Externí odkaz:
https://doaj.org/article/91b25af29668434ab4aa49d5b7aec570
Autor:
Tricia L. May-Dracka, Fang Gao, Brian T. Hopkins, Xiaoping Hronowski, TeYu Chen, Jayanth V. Chodaparambil, Claire M. Metrick, Mike Cullivan, Istvan Enyedy, Maciej Kaliszczak, Mark W. Kankel, Isaac Marx, Mackenzie A. Michell-Robinson, Param Murugan, P. Rajesh Kumar, Michael Rooney, Eli Schuman, Anindya Sen, Ti Wang, Tao Ye, Emily A. Peterson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. From a therapeutic perspective, PLD has been implicated in human canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe055bd69fb8ef7e48f9498480b28a32
https://europepmc.org/articles/PMC9014516/
https://europepmc.org/articles/PMC9014516/
Autor:
Xiaoping Hronowski, Haley Cirka, Molly M Rajsombath, Silke Nuber, Kevin J. Hodgetts, Christian P. Müller, Thibaut Imberdis, Andreas Weihofen, Ulf Dettmer, Dennis J. Selkoe, Saranna Fanning, Jürgen Winkler, Alice Y Nam, Liubov S. Kalinichenko, Vera Lambrecht, Junmin Wang
Publikováno v:
Annals of Neurology
Objective Parkinson disease (PD) has useful symptomatic treatments that do not slow the neurodegenerative process, and no significant disease-modifying treatments are approved. A key therapeutic target in PD is α-synuclein (αS), which is both genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf767deba263a4ec1a59f5fdd8c5bc9
https://doi.org/10.1002/ana.25920
https://doi.org/10.1002/ana.25920
Publikováno v:
Analytical chemistry. 92(15)
2-Aminobenzoic acid (2-AA) is widely used as a labeling reagent to derivatize released N-glycans at their free reducing terminus by reductive amination. 2-AA-labeled glycans have increased mass spectrometric sensitivity for their identification and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f07452c3d36fff05c823b70b57677e
https://pubmed.ncbi.nlm.nih.gov/32628832
https://pubmed.ncbi.nlm.nih.gov/32628832
Autor:
May-Dracka, Tricia L., Fang Gao, Hopkins, Brian T., Xiaoping Hronowski, TeYu Chen, Chodaparambil, Jayanth V., Metrick, Claire M., Cullivan, Mike, Enyedy, Istvan, Kaliszczak, Maciej, Kankel, Mark W., Marx, Isaac, Michell-Robinson, Mackenzie A., Murugan, Param, Kumar, P. Rajesh, Rooney, Michael, Schuman, Eli, Sen, Anindya, Ti Wang, Tao Ye
Publikováno v:
ACS Medicinal Chemistry Letters; 4/14/2022, Vol. 13 Issue 4, p665-673, 9p
Autor:
Carol Feghali-Bostwick, Fei Liu, Peter Juhasz, Xiaoping Hronowski, Qiurong Xiao, Steven Mullenbrock, Benbo Gao, Timothy S Zheng, Chao Sun, Suzanne Szak, Mei Liu, Helen McLaughlin
Publikováno v:
Genes, Vol 9, Iss 12, p 588 (2018)
Genes
Volume 9
Issue 12
Genes
Volume 9
Issue 12
Fibroblasts/myofibroblasts are the key effector cells responsible for excessive extracellular matrix (ECM) deposition and fibrosis progression in both idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc) patient lungs, thus it is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4e9939ba33af8f588f250f16d73024
https://doi.org/10.3390/genes9120588
https://doi.org/10.3390/genes9120588
Autor:
Xiaoping Hronowski, Alex Buko, Azita Kaffashan, Xin Zhang, Scott Bowes, Claudio Chuaqui, Serene Josiah, Dongyu Sun, Chenhui Zeng
Publikováno v:
SLAS Discovery. 11:828-835
A subset of the compound repository for lead identification at Biogen Idec was characterized for its chemical stability over a 3-year period. Compounds were stored at 4 °C as 10 mM DMSO stocks, and a small subset of compounds was stored as lyophiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f7b4e92b0ff5a3119000fadf79d427
https://doi.org/10.1177/1087057106290993
https://doi.org/10.1177/1087057106290993
Autor:
Ellen Garber, Alphonse Galdes, Dingyi Wen, Xiaoping Hronowski, Melissa Levesque, Kathryn L. Strauch, Alan Gill, Frederick R. Taylor, Renee I. Shapiro
Publikováno v:
Protein Expression and Purification. 29:272-283
We have investigated the suitability of Pichia pastoris as an expression system for the candidate therapeutic protein, Sonic hedgehog fused to an immunoglobulin Fc domain (Shh-Fc). Sonic hedgehog is a morphogen protein involved in the patterning of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550938fdbdc5ffc64e31a5f4740bfbfa
https://doi.org/10.1016/s1046-5928(03)00062-7
https://doi.org/10.1016/s1046-5928(03)00062-7
Autor:
Xiaoping Hronowski, Peter Juhasz, Kenneth J. Rhodes, Melanie S. Brennan, Maria F. Matos, Robert H. Scannevin, Benbo Gao, Bing Li
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 3, p e0120254 (2015)
PLoS ONE, Vol 10, Iss 3, p e0120254 (2015)
Delayed-release dimethyl fumarate (also known as gastro-resistant dimethyl fumarate), an oral therapeutic containing dimethyl fumarate (DMF) as the active ingredient, is currently approved for the treatment of relapsing multiple sclerosis. DMF is als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a547385540bcf1d6e0a81e92fe7e9dc
https://pubmed.ncbi.nlm.nih.gov/25793262
https://pubmed.ncbi.nlm.nih.gov/25793262
Publikováno v:
Analytical Chemistry. 73:4755-4762
Over the past decade, the growing number of recombinant glycoproteins used as therapeutic agents has prompted the development of robust and rugged methodologies for characterizing the glycosylation pattern of such molecules. The present study describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e513fb9d2f545e644a1ffc4b59c389
https://doi.org/10.1021/ac015560a
https://doi.org/10.1021/ac015560a