Zobrazeno 1 - 10
of 498
pro vyhledávání: '"Xiaoping Su"'
Autor:
Qingliu He, Qingfu Su, Chengcheng Wei, Pu Zhang, Weihui Liu, Junyi Chen, Xiaoping Su, Wei Zhuang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe role of focal amplifications and extrachromosomal circular DNA (eccDNA) is still uncertain in prostate adenocarcinoma (PRAD). Here, we first mapped the global characterizations of eccDNA and then investigate the characterization of eccD
Externí odkaz:
https://doaj.org/article/aeaa2c8f04424d60bb34d6e403df5faa
Autor:
Zhiwen Luo, Jie Mei, Xianwen Wang, Ruixin Wang, Zhao He, Yifat Geffen, Xiaomeng Sun, Xingyu Zhang, Junying Xu, Renwen Wan, Xinting Feng, Chunmeng Jiao, Xiaoping Su, Junming Sun, Shiyi Chen, Jiwu Chen, Wenjun Mao, Yunlong Yang, Yaying Sun
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114697- (2024)
Summary: Physical activity reduces cancer-associated mortality through multiple mechanisms, including tumor immune microenvironment (TIME) reprogramming. However, whether and how physiological interventions promote anti-tumor immunity remain elusive.
Externí odkaz:
https://doaj.org/article/29ce93c85dd14eeeb226eff22445678b
Publikováno v:
Journal of International Medical Research, Vol 52 (2024)
Objective Identifying precise biomarkers for colorectal cancer (CRC) detection and management remains challenging. Here, we developed an innovative prognostic model for CRC using cuproptosis-related long non-coding RNAs (lncRNAs). Methods In this ret
Externí odkaz:
https://doaj.org/article/e15311fd77c743e0b6b5f3aaf2b697ab
Autor:
Christopher P. Mill, Warren C. Fiskus, Courtney D. DiNardo, Patrick Reville, John A. Davis, Christine E. Birdwell, Kaberi Das, Hanxi Hou, Koichi Takahashi, Lauren Flores, Xinjia Ruan, Xiaoping Su, Sanam Loghavi, Joseph D. Khoury, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Germline, mono-allelic mutations in RUNX1 cause familial platelet disorder (RUNX1-FPD) that evolves into myeloid malignancy (FPD-MM): MDS or AML. FPD-MM commonly harbors co-mutations in the second RUNX1 allele and/or other epigenetic regulat
Externí odkaz:
https://doaj.org/article/b9424549a1ed49b58740fad27c6be69c
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102094- (2024)
Objective: PARPi offers less clinical benefit for HRP patients compared to HRD patients. PARPi has an immunomodulatory function. NRT therapy targets tumor neoantigens without off-target immune toxicity. We explored the synergy between Niraparib and N
Externí odkaz:
https://doaj.org/article/7debdf9a8f9f451984b690bc551583bc
Autor:
Xiaoping Su, Xiaofan Lu, Sehrish Khan Bazai, Linda Dainese, Arnauld Verschuur, Benoit Dumont, Roger Mouawad, Li Xu, Wenxuan Cheng, Fangrong Yan, Sabine Irtan, Véronique Lindner, Catherine Paillard, Yves Le Bouc, Aurore Coulomb, Gabriel G. Malouf
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Wilms tumors are highly curable in up to 90% of cases with a combination of surgery and radio-chemotherapy, but treatment-resistant types such as diffuse anaplastic Wilms tumors pose significant therapeutic challenges. Our multi-omics profil
Externí odkaz:
https://doaj.org/article/04f4843568a140c78ff076e8570ab074
Autor:
Chang Sun, Yuan Qi, Natalie Fowlkes, Nina Lazic, Xiaoping Su, Guillermina Lozano, Amanda R. Wasylishen
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-9 (2023)
Abstract Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including c
Externí odkaz:
https://doaj.org/article/a2b8e003959247d18bd59dc80dcac901
Autor:
Bujamin H. Vokshi, Guillaume Davidson, Nassim Tawanaie Pour Sedehi, Alexandra Helleux, Marc Rippinger, Alexandre R. Haller, Justine Gantzer, Jonathan Thouvenin, Philippe Baltzinger, Rachida Bouarich, Valeria Manriquez, Sakina Zaidi, Priya Rao, Pavlos Msaouel, Xiaoping Su, Hervé Lang, Thibault Tricard, Véronique Lindner, Didier Surdez, Jean-Emmanuel Kurtz, Franck Bourdeaut, Nizar M. Tannir, Irwin Davidson, Gabriel G. Malouf
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Renal medullary carcinoma (RMC) is an aggressive tumour driven by bi-allelic loss of SMARCB1 and tightly associated with sickle cell trait. However, the cell-of-origin and oncogenic mechanism remain poorly understood. Using single-cell seque
Externí odkaz:
https://doaj.org/article/01f90a34514d4d2a88792568e2a609ad
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Neoantigens generated by non-synonymous mutations of tumor genes can induce activation of neoantigen-reactive T (NRT) cells which have the ability to resist the growth of tumors expressing specific neoantigens. Immunotherapy based on NRT cel
Externí odkaz:
https://doaj.org/article/f1d5347f2f26465a9b0839c3c89141a5
Autor:
Warren Fiskus, Christopher P. Mill, Christine Birdwell, John A. Davis, Kaberi Das, Steffen Boettcher, Tapan M. Kadia, Courtney D. DiNardo, Koichi Takahashi, Sanam Loghavi, Michael J. Soth, Tim Heffernan, Gerard M. McGeehan, Xinjia Ruan, Xiaoping Su, Christopher R. Vakoc, Naval Daver, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Monotherapy with Menin inhibitor (MI), e.g., SNDX-5613, induces clinical remissions in patients with relapsed/refractory AML harboring MLL1-r or mtNPM1, but most patients either fail to respond or eventually relapse. Utilizing single-cell RN
Externí odkaz:
https://doaj.org/article/ac5251edf70f45ea8914536e1354701b