Zobrazeno 1 - 10 of 37 pro vyhledávání: '"Xiaoping, Ruan"'
1
Preclinical Characterization of LY3209590, a Novel Weekly Basal Insulin Fc-Fusion Protein
Autor: Julie S, Moyers, Ryan J, Hansen, Jonathan W, Day, Craig D, Dickinson, Chen, Zhang, Xiaoping, Ruan, Liyun, Ding, Robin M, Brown, Hana E, Baker, John M, Beals
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 382:346-355
The benefit of once-weekly basal insulin is less frequent dosing, which has the potential to reduce the barrier to injection therapy and impact patient activation, adherence and compliance, quality of life, and outcomes. Basal Insulin Fc (BIF, LY3209
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c435ab7265da35669d2b5357f9bdda
https://doi.org/10.1124/jpet.122.001105
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2
Financial Big Data Intelligent Service System Based on Cloud Computing of Internet of Things
Autor: Meiping Gao, Qingfang He, Xiaoping Ruan
Publikováno v: Mobile Information Systems.
The financial big data intelligent service system belongs to the technical field of financial data management. It is an innovation of the client and server of the financial service system, which promotes the electronic office of the financial system.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607c5a0590281aaaa46854decfb61623
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3
Akademický článek
Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice.
Autor: Daniel A Briere, Xiaoping Ruan, Christine C Cheng, Angela M Siesky, Thomas E Fitch, Carmen Dominguez, Sonia Gutierrez Sanfeliciano, Carlos Montero, Chen S Suen, Yanping Xu, Tamer Coskun, M Dodson Michael
Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0136873 (2015)
Activation of TGR5 via bile acids or bile acid analogs leads to the release of glucagon-like peptide-1 (GLP-1) from intestine, increases energy expenditure in brown adipose tissue, and increases gallbladder filling with bile. Here, we present compoun
Externí odkaz: https://doaj.org/article/0e3cad23ebd14667ac97596b703b1f92
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6
1009-P: The Dual GIP and GLP-1 Receptor Agonist Tirzepatide Regulates Lipid and Carbohydrate Metabolism through GIPR in Adipose Tissue
Autor: Julie S. Moyers, Ajit Regmi, Ricardo J. Samms, William C. Roell, Michael E. Christe, Xiaoping Ruan
Publikováno v: Diabetes. 68
Tirzepatide (TZP), a GIP receptor and GLP-1 receptor (GIPR/GLP-1R) dual agonist, has demonstrated profound effects on glycemic control and bodyweight lowering in T2D subjects. However, the mechanism of action for the dual agonism of TZP is incomplete
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b779e9f7201b9a0ad40a05898b06a2a
https://doi.org/10.2337/db19-1009-p
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7
139-OR: GIP Regulates Fatty Acid and Glycerol Synthesis in Human Adipocytes
Autor: Kenneth D. Roth, Paul L. Milligan, William C. Roell, Haitao Hu, Ajit Regmi, Julie S. Moyers, Xiaoping Ruan
Publikováno v: Diabetes. 68
Activation of GIP (glucose-dependent insulinotropic peptide) receptor (GIPR) in combination with GLP-1 receptor has demonstrated reduced adiposity and bodyweight in mice. Although the incretin action of GIP in pancreatic beta cells is well characteri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a1bba32643d1b5d80942f63d2446b0f
https://doi.org/10.2337/db19-139-or
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8
In Vivo and In Vitro Characterization of Basal Insulin Peglispro: A Novel Insulin Analog
Autor: John Michael Beals, Hui-Rong Qian, Steven D. Kahl, Xiaoping Ruan, Gordon B. Cutler, Andrew Mark Vick, Owens Rebecca Anne, Julie S. Moyers, Mark W. Farmen, M. Dodson Michael, Shun Li, Ryan John Hansen, Chen Zhang, Anja Koester
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 357:459-465
The aim of this research was to characterize the in vivo and in vitro properties of basal insulin peglispro (BIL), a new basal insulin, wherein insulin lispro was derivatized through the covalent and site-specific attachment of a 20-kDa polyethylene-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c2025f98992771961b7f38e68e34dd
https://doi.org/10.1124/jpet.115.231035
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9
Application of Accounting in Human Resource Management
Autor: Shijun Liu, Xiaoping Ruan
Publikováno v: Proceedings of the 6th International Conference on Electronic, Mechanical, Information and Management Society.
W ith the continuous development of economy, the function of human resources in terms of business management has been highlighted. Nowadays, enterprises have paid much attention to talents while the proportion of human resources cost is higher and hi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ec0976a09fc6cf129ef7d6d951e9587
https://doi.org/10.2991/emim-16.2016.12
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10
Study on the Morphological Evolution and Boundary Spanning Role Generative Mechanism of Human Resource Management from the Perspective of Organization
Autor: Xiaoping Ruan, Shijun Liu
Publikováno v: Proceedings of the 6th International Conference on Electronic, Mechanical, Information and Management Society.
W ith the development of economy, the human resource environment in China has been greatly optimized and improved, especially in terms of the management level.The human resource management adjustment as well as the boundary spanning role generative m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6651aac993548409faaf6593bcb968ab
https://doi.org/10.2991/emim-16.2016.53
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