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Akademický článek

Statistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals

Autor: Ligang Xia, Zhoufang Li, Bo Zhou, Geng Tian, Lidong Zeng, Hongyu Dai, Xiaohua Li, Chaoyu Liu, Shixin Lu, Feiyue Xu, Xiaonian Tu, Fang Deng, Yuancai Xie, Weiren Huang, Jiankui He

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Abstract Cell-free DNA (cfDNA) in plasma has emerged as a potential important biomarker in clinical diagnostics, particularly in cancer. However, somatic mutations are also commonly found in healthy individuals, which interfere with the effectiveness

Externí odkaz: https://doaj.org/article/72223ec9b9014ea794371c47787bfe64

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Multi-Center Study of Resectable Lung Lesions by Ultra-Deep Sequencing of Targeted Genes in Plasma Cell-Free DNA to Assess Nodule Malignancy and Detect Lung Cancers

Autor: Hsiao-Ching Yang, Chao Xu, Xifei Li, Xumei Yao, Fengjun Cao, Qian Y, Cheng F, Feiyue Xu, Jiankui He, Muyun Peng, Geng Tian, Chaoyu Liu, Xie Yuanhong, Bing He, Kong D, Fenglei Yu, Xiaonian Tu

BACKGROUNDEarly detection of lung cancer to allow curative treatment remains challenging. Cell-free circulating tumor DNA (ctDNA) analysis may aid in malignancy assessment and early cancer diagnosis of lung nodules found in screening imagery.METHODST

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261392e66310a9c9504d8e4898390262
https://doi.org/10.1101/453803

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Resectable lung lesions malignancy assessment and cancer detection by ultra-deep sequencing of targeted gene mutations in plasma cell-free DNA

Autor: Fengjun Cao, Fenglei Yu, Chaoyu Liu, Feiyue Xu, Yuancai Xie, Chuanbo Xu, Haoxian Yang, Bing He, Fangsheng Cheng, Youhui Qian, Geng Tian, Xiaohua Li, Muyun Peng, Xumei Yao, Xiaonian Tu, Deju Kong

Publikováno v: Journal of Medical Genetics

BackgroundEarly detection of lung cancer to allow curative treatment remains challenging. Cell-free circulating tumour (ct) DNA (ctDNA) analysis may aid in malignancy assessment and early cancer diagnosis of lung nodules found in screening imagery.Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef5a967e069dcda5b49f3383f758102
https://pubmed.ncbi.nlm.nih.gov/30981987

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Akademický článek

Resectable lung lesions malignancy assessment and cancer detection by ultra-deep sequencing of targeted gene mutations in plasma cell-free DNA.

Autor: Muyun Peng, Yuancai Xie, Xiaohua Li, Youhui Qian, Xiaonian Tu, Xumei Yao, Fangsheng Cheng, Feiyue Xu, Deju Kong, Bing He, Chaoyu Liu, Fengjun Cao, Haoxian Yang, Fenglei Yu, Chuanbo Xu, Geng Tian

Publikováno v: Journal of Medical Genetics; Oct2019, Vol. 56 Issue 10, p647-653, 7p

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The Early Diagnosis in Lung Cancer by the Detection of Circulating Tumor DNA

Autor: Geng Tian, Feiyue Xu, Xuanbin Wang, Dan Yu, Yuancai Xie, Jiankui He, Fengjun Cao, Chaoyu Liu, Fenglei Yu, Xiaohua Li, Xumei Yao, Xiaonian Tu, Lu Shixin, Weiquan Zhong

BackgroundRemarkable advances for clinical diagnosis and treatment in cancers including lung cancer involve cell-free circulating tumor DNA (ctDNA) detection through next generation sequencing. However, before the sensitivity and specificity of ctDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5960e05125cbb4853ac135de2a12d070
https://doi.org/10.1101/189340

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Statistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals

Autor: Xiaonian Tu, Fang Deng, Feiyue Xu, Yuancai Xie, Lidong Zeng, Lu Shixin, Ligang Xia, Xiaohua Li, Bo Zhou, Geng Tian, Jiankui He, Hongyu Dai, Zhoufang Li, Weiren Huang, Chaoyu Liu

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Cell-free DNA (cfDNA) in plasma has emerged as a potential important biomarker in clinical diagnostics, particularly in cancer. However, somatic mutations are also commonly found in healthy individuals, which interfere with the effectiveness for canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b8ff3e34e307ade5850245795915d5
https://pubmed.ncbi.nlm.nih.gov/28790338

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Multi-centre clinical study of cell-free DNA mutations in benign and malignant lung lesions

Autor: Fengjun Cao, Lu Shixin, Fenglei Yu, Youhui Qian, Geng Tian, Dan Yu, Feiyue Xu, Xiaohua Li, Xiaonian Tu, Fangsheng Cheng, Xumei Yao, Chaoyu Liu, Jiankui He, Chuanbo Xu, Wenling Xie, Muyun Peng, Yuancai Xie, Bing He, Xuanbin Wang

Publikováno v: Journal of Clinical Oncology. 36:e24036-e24036

e24036Background: Cell-free circulating tumor DNA (ctDNA) for cancer detection drew significant clinical attention. Concordance of mutations in tumor tissue and ctDNA should be evaluated first. Met...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bb855b7e105bf3c0b81abbb7da1947d
https://doi.org/10.1200/jco.2018.36.15_suppl.e24036

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