Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Xiaomu Wei"'
Autor:
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Low frequency coding single-nucleotide variants (SNVs) are predicted to disproportionately affect protein function. Here, the authors evaluate 2,009 missense SNVs across 2,185 protein-protein interactions using yeast two-hybrid and protein complement
Externí odkaz:
https://doaj.org/article/6ca43b750ead45778c9bbf8306bf1546
Autor:
Yardena Samuels, Carlos López-Otín, Jeffrey E. Gershenwald, Michael A. Davies, Steven A. Rosenberg, Pedro Cruz, Isabel Cardenas-Navia, Jimmy C. Lin, Alfredo Molinolo, Cristina G. Viloria, Todd D. Prickett, Xiaomu Wei
PDF file - 431K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d5bd504b4d563f9027682fb0e3a544
https://doi.org/10.1158/1541-7786.22518732
https://doi.org/10.1158/1541-7786.22518732
Autor:
Yardena Samuels, Carlos López-Otín, Jeffrey E. Gershenwald, Michael A. Davies, Steven A. Rosenberg, Pedro Cruz, Isabel Cardenas-Navia, Jimmy C. Lin, Alfredo Molinolo, Cristina G. Viloria, Todd D. Prickett, Xiaomu Wei
The disintegrin-metalloproteinases with thrombospondin domains (ADAMTS) genes have been suggested to function as tumor suppressors as several have been found to be epigenetically silenced in various cancers. We performed a mutational analysis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11703b25d3b8e3bc4e02fa87898149be
https://doi.org/10.1158/1541-7786.c.6542100
https://doi.org/10.1158/1541-7786.c.6542100
Autor:
Steven M. Lipkin, Leandro Cerchietti, Haiyuan Yu, Robert J. Klein, Kenneth Offit, Nicola J. Camp, Charles G. Mullighan, Henry T. Lynch, Charles Dumontet, Robert G. Roeder, Mark J. Daly, Kenneth C. Anderson, Judy E. Garber, Jane Churpek, Lucy A. Godley, Susan L. Slager, Ola Landgren, Ruben Niesvizky, Djordje Atanackovic, Mohamed Salama, Karen Curtin, Selina Chen-Kiang, Jude Phillip, Jayeshkumar Patel, Agnes Viale, Mykyta Artomov, Rosalie G. Waller, Dina Becirovic, Lauren M. Jacobs, David S. Jayabalan, Shu-Ping Wang, James D. McKay, Celine M. Vachon, Carrie Snyder, Vijai Joseph, Kim E. Nichols, Michael F. Walsh, Jinghui Zhang, Jian Sun, Maria V. Revuelta, Gang Wu, Siwei Chen, M. Nieves Calvo-Vidal, Xiaomu Wei
Clinical characteristics of familial myeloma probands who were studied with germline whole exome sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6df7cb64b7f19d76ead355dfb784944
https://doi.org/10.1158/0008-5472.22415838.v1
https://doi.org/10.1158/0008-5472.22415838.v1
Autor:
Steven M. Lipkin, Leandro Cerchietti, Haiyuan Yu, Robert J. Klein, Kenneth Offit, Nicola J. Camp, Charles G. Mullighan, Henry T. Lynch, Charles Dumontet, Robert G. Roeder, Mark J. Daly, Kenneth C. Anderson, Judy E. Garber, Jane Churpek, Lucy A. Godley, Susan L. Slager, Ola Landgren, Ruben Niesvizky, Djordje Atanackovic, Mohamed Salama, Karen Curtin, Selina Chen-Kiang, Jude Phillip, Jayeshkumar Patel, Agnes Viale, Mykyta Artomov, Rosalie G. Waller, Dina Becirovic, Lauren M. Jacobs, David S. Jayabalan, Shu-Ping Wang, James D. McKay, Celine M. Vachon, Carrie Snyder, Vijai Joseph, Kim E. Nichols, Michael F. Walsh, Jinghui Zhang, Jian Sun, Maria V. Revuelta, Gang Wu, Siwei Chen, M. Nieves Calvo-Vidal, Xiaomu Wei
PCA and gene based rare synonymous variant comparison analyses of European ancestry Multiple Myeloma cases and controls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6edc68f473dc9ce25d3205f8329f86
https://doi.org/10.1158/0008-5472.22415844
https://doi.org/10.1158/0008-5472.22415844
Autor:
Steven M. Lipkin, Leandro Cerchietti, Haiyuan Yu, Robert J. Klein, Kenneth Offit, Nicola J. Camp, Charles G. Mullighan, Henry T. Lynch, Charles Dumontet, Robert G. Roeder, Mark J. Daly, Kenneth C. Anderson, Judy E. Garber, Jane Churpek, Lucy A. Godley, Susan L. Slager, Ola Landgren, Ruben Niesvizky, Djordje Atanackovic, Mohamed Salama, Karen Curtin, Selina Chen-Kiang, Jude Phillip, Jayeshkumar Patel, Agnes Viale, Mykyta Artomov, Rosalie G. Waller, Dina Becirovic, Lauren M. Jacobs, David S. Jayabalan, Shu-Ping Wang, James D. McKay, Celine M. Vachon, Carrie Snyder, Vijai Joseph, Kim E. Nichols, Michael F. Walsh, Jinghui Zhang, Jian Sun, Maria V. Revuelta, Gang Wu, Siwei Chen, M. Nieves Calvo-Vidal, Xiaomu Wei
Given the frequent and largely incurable occurrence of multiple myeloma, identification of germline genetic mutations that predispose cells to multiple myeloma may provide insight into disease etiology and the developmental mechanisms of its cell of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd377612b42b805fb83de8caedd750d
https://doi.org/10.1158/0008-5472.c.6509400
https://doi.org/10.1158/0008-5472.c.6509400
Autor:
Steven M. Lipkin, Leandro Cerchietti, Haiyuan Yu, Robert J. Klein, Kenneth Offit, Nicola J. Camp, Charles G. Mullighan, Henry T. Lynch, Charles Dumontet, Robert G. Roeder, Mark J. Daly, Kenneth C. Anderson, Judy E. Garber, Jane Churpek, Lucy A. Godley, Susan L. Slager, Ola Landgren, Ruben Niesvizky, Djordje Atanackovic, Mohamed Salama, Karen Curtin, Selina Chen-Kiang, Jude Phillip, Jayeshkumar Patel, Agnes Viale, Mykyta Artomov, Rosalie G. Waller, Dina Becirovic, Lauren M. Jacobs, David S. Jayabalan, Shu-Ping Wang, James D. McKay, Celine M. Vachon, Carrie Snyder, Vijai Joseph, Kim E. Nichols, Michael F. Walsh, Jinghui Zhang, Jian Sun, Maria V. Revuelta, Gang Wu, Siwei Chen, M. Nieves Calvo-Vidal, Xiaomu Wei
Additional methods, statistical and resource information to assist readers about how experiments and analyses were conducted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7316162caa1627111ed388b4cc0633
https://doi.org/10.1158/0008-5472.22415847
https://doi.org/10.1158/0008-5472.22415847
Autor:
Rosalie G Waller, Todd M Darlington, Xiaomu Wei, Michael J Madsen, Alun Thomas, Karen Curtin, Hilary Coon, Venkatesh Rajamanickam, Justin Musinsky, David Jayabalan, Djordje Atanackovic, S Vincent Rajkumar, Shaji Kumar, Susan Slager, Mridu Middha, Perrine Galia, Delphine Demangel, Mohamed Salama, Vijai Joseph, James McKay, Kenneth Offit, Robert J Klein, Steven M Lipkin, Charles Dumontet, Celine M Vachon, Nicola J Camp
Publikováno v:
PLoS Genetics, Vol 14, Iss 2, p e1007111 (2018)
The high-risk pedigree (HRP) design is an established strategy to discover rare, highly-penetrant, Mendelian-like causal variants. Its success, however, in complex traits has been modest, largely due to challenges of genetic heterogeneity and complex
Externí odkaz:
https://doaj.org/article/56a1a4b3c7db428994e077fd4e8c5a93
Autor:
Xiaomu Wei, Jishnu Das, Robert Fragoza, Jin Liang, Francisco M Bastos de Oliveira, Hao Ran Lee, Xiujuan Wang, Matthew Mort, Peter D Stenson, David N Cooper, Steven M Lipkin, Marcus B Smolka, Haiyuan Yu
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004819 (2014)
Understanding the functional relevance of DNA variants is essential for all exome and genome sequencing projects. However, current mutagenesis cloning protocols require Sanger sequencing, and thus are prohibitively costly and labor-intensive. We desc
Externí odkaz:
https://doaj.org/article/520bfb2ab08946fca05281b99ffe8bde
Autor:
Siqi Liang, Li Yao, Christen A. Rivera-Erick, David Neil Cooper, Matthew Mort, Andrew G. Clark, Alon Keinan, Xiaomu Wei, Haiyuan Yu, Ting-Yi Wang, Peter D. Stenson, Kaixiong Ye, Jin Liang, Robert Fragoza, John C. Schimenti, Shayne D. Wierbowski, Juan Felipe Beltrán, Jishnu Das, Tina N. Tran
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Each human genome carries tens of thousands of coding variants. The extent to which this variation is functional and the mechanisms by which they exert their influence remains largely unexplored. To address this gap, we leverage the ExAC database of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b2ebb89d9247e39d02f138310b95ca
https://doaj.org/article/6ca43b750ead45778c9bbf8306bf1546
https://doaj.org/article/6ca43b750ead45778c9bbf8306bf1546