Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Xiaomei T Kuang"'
Autor:
Laura A Cotton, Xiaomei T Kuang, Anh Q Le, Jonathan M Carlson, Benjamin Chan, Denis R Chopera, Chanson J Brumme, Tristan J Markle, Eric Martin, Aniqa Shahid, Gursev Anmole, Philip Mwimanzi, Pauline Nassab, Kali A Penney, Manal A Rahman, M-J Milloy, Martin T Schechter, Martin Markowitz, Mary Carrington, Bruce D Walker, Theresa Wagner, Susan Buchbinder, Jonathan Fuchs, Beryl Koblin, Kenneth H Mayer, P Richard Harrigan, Mark A Brockman, Art F Y Poon, Zabrina L Brumme
Publikováno v:
PLoS Genetics, Vol 10, Iss 4, p e1004295 (2014)
HLA-restricted immune escape mutations that persist following HIV transmission could gradually spread through the viral population, thereby compromising host antiviral immunity as the epidemic progresses. To assess the extent and phenotypic impact of
Externí odkaz:
https://doaj.org/article/5120521a2c5e4e9facd0fbd9fe45093e
Autor:
Denis R Chopera, Jaclyn K Mann, Philip Mwimanzi, Saleha Omarjee, Xiaomei T Kuang, Nonkululeko Ndabambi, Sarah Goodier, Eric Martin, Vivek Naranbhai, Salim Abdool Karim, Quarraisha Abdool Karim, Zabrina L Brumme, Thumbi Ndung'u, Carolyn Williamson, Mark A Brockman, CAPRISA 004 TRAPS Team
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71758 (2013)
Use of antiretroviral-based microbicides for HIV-1 prophylaxis could introduce a transmission barrier that inadvertently facilitates the selection of fitter viral variants among incident infections. To investigate this, we assessed the in vitro funct
Externí odkaz:
https://doaj.org/article/0beb17d4573a4c7a973a67afa52ef387
Autor:
Steven W. Jin, Nirmin Alsahafi, Xiaomei T. Kuang, Shayda A. Swann, Mako Toyoda, Heinrich Göttlinger, Bruce D. Walker, Takamasa Ueno, Andrés Finzi, Zabrina L. Brumme, Mark A. Brockman
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1449-1457.e5 (2019)
Summary: HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5; however, the impact of natural Nef polymorphisms on this function is largely unknown. We characterize SERINC5 downregulation activity of 91 primary HIV-1
Externí odkaz:
https://doaj.org/article/165b49a277584f7aa63f416ef63bfe38
Autor:
Xiaomei T. Kuang, Mark A. Brockman
Publikováno v:
Viruses, Vol 10, Iss 12, p 677 (2018)
Finding a cure for HIV is challenging because the virus is able to integrate itself into the host cell genome and establish a silent state, called latency, allowing it to evade antiviral drugs and the immune system. Various “shock and kill„ strat
Externí odkaz:
https://doaj.org/article/0d187712a07243e09f7609ad7915c390
Autor:
Heinrich G. Göttlinger, Mark A. Brockman, Bruce D. Walker, Zabrina L. Brumme, Shayda A. Swann, Steven W. Jin, Takamasa Ueno, Xiaomei T. Kuang, Nirmin Alsahafi, Mako Toyoda, Andrés Finzi
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1449-1457.e5 (2019)
Cell reports
Cell reports
SUMMARY HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5; however, the impact of natural Nef polymorphisms on this function is largely unknown. We characterize SERINC5 downregulation activity of 91 primary HIV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2353b482383a5baa7eb947651f764a02
http://www.sciencedirect.com/science/article/pii/S2211124719313002
http://www.sciencedirect.com/science/article/pii/S2211124719313002
Autor:
Zabrina L. Brumme, Steven W. Jin, Mark A. Brockman, Asa Rahimi, Gursev Anmole, Tristan J. Markle, Xiaomei T. Kuang
Publikováno v:
Virology. 530
HIV-1 Nef modulates the activation state of CD4+ T cells by altering signaling events elicited by the T cell receptor (TCR). Primary nef sequences exhibit extensive inter-individual diversity that influences their ability to downregulate CD4 and HLA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d4798f56f2ac5db1d61c9c79c7ee30
https://pubmed.ncbi.nlm.nih.gov/30780124
https://pubmed.ncbi.nlm.nih.gov/30780124
Autor:
Zabrina L. Brumme, Xiaomei T. Kuang, Alex Olvera, Mark A. Brockman, Montserrat Plana, Laura A. Cotton, Aniqa Shahid, Gursev Anmole, Christian Brander
Publikováno v:
Journal of Virology. 89:11557-11571
HLA-B*13 is associated with superior in vivo HIV-1 viremia control. Protection is thought to be mediated by sustained targeting of key cytotoxic T lymphocyte (CTL) epitopes and viral fitness costs of CTL escape in Gag although additional factors may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2032ed139ced33b482c315c41157468d
https://doi.org/10.1128/jvi.01955-15
https://doi.org/10.1128/jvi.01955-15
Autor:
Takamasa Ueno, Zabrina L. Brumme, Bemuluyigza Baraki, Gursev Anmole, Mark A. Brockman, Eric Martin, R. Brad Jones, Mako Toyoda, Aniqa Shahid, Tristan J. Markle, Xiaomei T. Kuang, Anh Q. Le, Mario A. Ostrowski
Publikováno v:
Journal of Immunological Methods. 426:104-113
HIV-1 evades cytotoxic T cell responses through Nef-mediated downregulation of HLA class I molecules from the infected cell surface. Methods to quantify the impact of Nef on T cell recognition typically employ patient-derived T cell clones; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd4922ac4cf7296b929c81e509dea81
https://doi.org/10.1016/j.jim.2015.08.010
https://doi.org/10.1016/j.jim.2015.08.010
Autor:
Zabrina L. Brumme, Cassandra N. Naphen, Natalie N. Kinloch, Silven Read, David E. Williams, Brendan Bell, Tristan J. Markle, Philip Mwimanzi, Xiaomei T. Kuang, Mark A. Brockman, Ian Tietjen, Mark A. Wainberg, Emmanuelle Wilhelm, Raymond J. Andersen, Phillip Crews, Karen Tenney, Thibault Mesplède
Publikováno v:
Antiviral research. 152
HIV-1 inhibitors that act by mechanisms distinct from existing antiretrovirals can provide novel insights into viral replication and potentially inform development of new therapeutics. Using a multi-cycle HIV-1 replication assay, we screened 252 pure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f745808c217f31ce147345977a328f
https://pubmed.ncbi.nlm.nih.gov/29476895
https://pubmed.ncbi.nlm.nih.gov/29476895
Autor:
Zabrina L. Brumme, Martin Markowitz, Louise Chong, Gursev Anmole, Heiko Jessen, Philip Mwimanzi, Mark A. Brockman, Xiaoguang Li, Aniqa Shahid, Hua Qian, Florencia Pereyra, Susan J. Little, Tristan J. Markle, Eric S. Daar, Elizabeth Connick, Xiaomei T. Kuang, Toshiyuki Miura, Anh Q. Le, Bemuluyigza Baraki, Takamasa Ueno, Anthony D. Kelleher, Eric S. Rosenberg, Bruce D. Walker
Publikováno v:
Journal of virology, vol 88, iss 17
Host and viral factors influence the HIV-1 infection course. Reduced Nef function has been observed in HIV-1 controllers during the chronic phase, but the kinetics and mechanisms of Nef attenuation in such individuals remain unclear. We examined plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05eb19018c445fe1987529b0ab2b090
https://doi.org/10.1128/jvi.01334-14
https://doi.org/10.1128/jvi.01334-14