Zobrazeno 1 - 10
of 898
pro vyhledávání: '"Xiaomei, Chen"'
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been shown to provide cardiovascular benefits in patients with type 2 diabetes mellitus (T2DM). However, their cardiovascular protective efficacy in high-risk T2DM patient
Externí odkaz:
https://doaj.org/article/abac0b3fb68f4375914b61117368621b
Autor:
Xiaomei Chen, Henrik B. Nyberg, Mark Donnelly, Liang Zhao, Lanyan Fang, Mats O. Karlsson, Andrew C. Hooker
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1734-1747 (2024)
Abstract By applying nonlinear mixed‐effect (NLME) models, model‐integrated evidence (MIE) approaches are able to analyze bioequivalence (BE) data with pharmacokinetic end points that have sparse sampling, which is problematic for non‐compartme
Externí odkaz:
https://doaj.org/article/2e1329167ac44ce096430f86304bb58d
Autor:
Xiaomei Chen, Rikard Nordgren, Stella Belin, Alzahra Hamdan, Shijun Wang, Tianwu Yang, Zhe Huang, Simon J. Carter, Simon Buatois, João A. Abrantes, Andrew C. Hooker, Mats O. Karlsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1784-1797 (2024)
Abstract Population pharmacokinetic (PK) models are widely used to inform drug development by pharmaceutical companies and facilitate drug evaluation by regulatory agencies. Developing a population PK model is a multi‐step, challenging, and time‐
Externí odkaz:
https://doaj.org/article/7b021a7f7b66484a8b7f9eaa81834ea5
Autor:
Henrik Bjugård Nyberg, Xiaomei Chen, Mark Donnelly, Lanyan Fang, Liang Zhao, Mats O. Karlsson, Andrew C. Hooker
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1748-1761 (2024)
Abstract Conventional approaches for establishing bioequivalence (BE) between test and reference formulations using non‐compartmental analysis (NCA) may demonstrate low power in pharmacokinetic (PK) studies with sparse sampling. In this case, model
Externí odkaz:
https://doaj.org/article/818524a9727b4db99705ea0d5a2a6947
Autor:
Li Wei, Miao Liu, Shisi Zhang, Yujie Chen, Min Wu, Xiaomei Chen, Jia Liu, Yuxuan He, Xue Yang, Jishu Xian
Publikováno v:
BMC Surgery, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Preoperative frailty is a risk factor associated with postoperative delirium (POD), which has attracted more attention from clinicians, but no research has shown that it is related to elderly patients undergoing craniotomy. Theref
Externí odkaz:
https://doaj.org/article/46540830e020418994736205a1f38b4c
Autor:
Alzahra Hamdan, Andrew C. Hooker, Xiaomei Chen, Andreas Traschütz, Rebecca Schüle, ARCA Study Group, EVIDENCE‐RND consortium, Matthis Synofzik, Mats O. Karlsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1327-1340 (2024)
Abstract The Scale for the Assessment and Rating of Ataxia (SARA) is widely used for assessing the severity and progression of genetic cerebellar ataxias. SARA is now considered a primary end point in several ataxia treatment trials, but its underlyi
Externí odkaz:
https://doaj.org/article/ca2491fc5edd4d2f979817cba54b2637
Autor:
Jiani Wang, Zhongsheng Tong, Yinuo Tan, Yehui Shi, Yun Wu, Qing Zhou, Xiaoyan Xing, Xiaomei Chen, Fuming Qiu, Fei Ma
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101707- (2024)
Summary: This phase 1a study assesses ESG401 in patients with heavily pretreated locally advanced or metastatic solid tumors, focusing on metastatic breast cancer. Forty patients are enrolled: three experience dose-limiting toxicities, establishing t
Externí odkaz:
https://doaj.org/article/736f4c38ba8e4e2ca5a20e6083c652d7
Publikováno v:
BMC Psychology, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Objective This study aimed to investigate the relationships between childhood maltreatment, shame, and self-esteem among juvenile female offenders and to explore the potential influencing factors on their criminal behavior. Methods Using a s
Externí odkaz:
https://doaj.org/article/463441a839be4f65a1d7811efbee5bfa
Publikováno v:
BMC Psychology, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract This study explores the relationship between social withdrawal and problematic social media use among college students, with a focus on the mediating roles of alexithymia and negative body image. Using the University Student Social Withdrawa
Externí odkaz:
https://doaj.org/article/586cb490855f4a86b3e7139419856b9a
Autor:
Shichao Yang, Caden Hu, Xiaomei Chen, Yi Tang, Juanjuan Li, Hanqing Yang, Yi Yang, Binwu Ying, Xue Xiao, Shang‑Ze Li, Li Gu, Yahui Zhu
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy
Externí odkaz:
https://doaj.org/article/0d1187fe97aa4c898e8fbb879b6881f6