Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Xiaolai Zhou"'
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/394569f28f274191bb0019a0aadd856b
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
ObjectivesThe purpose of this study was to explore whether team-based learning (TBL) was more effective than traditional didactic lectures (TDLs) in improving medical students' problem-solving and study skills in the clinical course of ophthalmology.
Externí odkaz:
https://doaj.org/article/fa1ba1d6490a4683a38ff242812616eb
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background Loss of function mutations in progranulin (GRN) are a major cause of frontotemporal dementia (FTD). Progranulin is a secreted glycoprotein that localizes to lysosomes and is critical for proper lysosomal function. Heterozygous GRN
Externí odkaz:
https://doaj.org/article/a59bbbf5eb524493965514b250bd17c3
Autor:
Alexandra M. Nicholson, Xiaolai Zhou, Ralph B. Perkerson, Tammee M. Parsons, Jeannie Chew, Mieu Brooks, Mariely DeJesus-Hernandez, NiCole A. Finch, Billie J. Matchett, Aishe Kurti, Karen R. Jansen-West, Emilie Perkerson, Lillian Daughrity, Monica Castanedes-Casey, Linda Rousseau, Virginia Phillips, Fenghua Hu, Tania F. Gendron, Melissa E. Murray, Dennis W. Dickson, John D. Fryer, Leonard Petrucelli, Rosa Rademakers
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Loss-of-function mutations in progranulin (GRN) and a non-coding (GGGGCC)n hexanucleotide repeat expansions in C9ORF72 are the two most common genetic causes of frontotemporal lobar degeneration with aggregates of TAR DNA binding protein 43
Externí odkaz:
https://doaj.org/article/80b59b9ee2f04833abccd21624f3cfba
Autor:
Xiaolai Zhou, Lirong Sun, Oliver Bracko, Ji Whae Choi, Yan Jia, Alissa L. Nana, Owen Adam Brady, Jean C. Cruz Hernandez, Nozomi Nishimura, William W. Seeley, Fenghua Hu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Mutations in the granulin gene are associated with frontotemporal lobe dementia (FTLD) and a lysosomal storage disease. The authors show that reduced progranulin levels leads to impaired neuronal uptake and lysosomal delivery of prosaposin, and that
Externí odkaz:
https://doaj.org/article/41d78f62c0c2475397bd2fa199e6bc5b
Autor:
Xiaolai Zhou, Daniel H Paushter, Mitchell D Pagan, Dongsung Kim, Mariela Nunez Santos, Raquel L Lieberman, Herman S Overkleeft, Ying Sun, Marcus B Smolka, Fenghua Hu
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0212382 (2019)
Mutation in the GRN gene, encoding the progranulin (PGRN) protein, shows a dose-dependent disease correlation, wherein haploinsufficiency results in frontotemporal lobar degeneration (FTLD) and complete loss results in neuronal ceroid lipofuscinosis
Externí odkaz:
https://doaj.org/article/f702a5e6783641b88e7bf48fd81d95ed
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Microglia are involved in physiological as well as neuropathological processes in the central nervous system (CNS). Their functional states are often referred to as M1-like and M2-like activation, and are believed to contribute to neuroinflammation-m
Externí odkaz:
https://doaj.org/article/f349d0ff0bb143c7a3251de372b2b86e
Autor:
Peter M. Sullivan, Tuancheng Feng, Isabel Iscol Katz, Rory R Sheng, Daniel H. Paushter, Santiago Solé-Domènech, Fenghua Hu, Frederick R. Maxfield, Mohammed Ullah, Xiaochun Wu, Christina S. Mendoza, Laura Camila Martinez Enriquez, Xiaolai Zhou
Publikováno v:
Brain
TMEM106B encodes a lysosomal membrane protein and was initially identified as a risk factor for frontotemporal lobar degeneration. Recently, a dominant D252N mutation in TMEM106B was shown to cause hypomyelinating leukodystrophy. However, how TMEM106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce1776de72ec84aac9e04683d5aca86
https://doi.org/10.1093/brain/awaa154
https://doi.org/10.1093/brain/awaa154
Publikováno v:
Brain Communications. 4
Haploinsufficiency of the progranulin protein is a leading cause of frontotemporal lobar degeneration. Accumulating evidence support a crucial role of progranulin in the lysosome. Progranulin comprises 7.5 granulin repeats and is known to traffic to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c35eb3603296bf635786dd5fb1ccdd9
https://doi.org/10.1093/braincomms/fcab310
https://doi.org/10.1093/braincomms/fcab310
Autor:
Cristhoper H. Fernandez De Castro, Matthew C. Baker, Dennis W. Dickson, Shunsuke Koga, Aya Murakami, Xiaolai Zhou, Rosa Rademakers
Publikováno v:
Neuropathology and applied neurobiology
AimsAccumulating evidence suggests that patients with frontotemporal lobar degeneration (FTLD) can have pathologic accumulation of multiple proteins, including tau and TDP-43. This study aimed to determine the frequency and characteristics of concurr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa47b0f7429f7048edaa8cf6cf3e632
https://doi.org/10.1111/nan.12778
https://doi.org/10.1111/nan.12778